PMID- 26710939
OWN - NLM
STAT- MEDLINE
DCOM- 20170818
LR  - 20170818
IS  - 1600-0714 (Electronic)
IS  - 0904-2512 (Linking)
VI  - 45
IP  - 7
DP  - 2016 Aug
TI  - Trend of Cadherin-11 expression and its impact on cartilage degradation in the 
      temporomandibular joints of guinea pigs with spontaneous osteoarthritis.
PG  - 534-8
LID - 10.1111/jop.12403 [doi]
AB  - BACKGROUND: This study aims to investigate spatial and temporal changes in 
      cadherin-11 (CAD-11) expression and their effects on cartilage degeneration in 
      the temporomandibular joint (TMJ) of guinea pigs with spontaneous osteoarthritis 
      (OA). METHODS: Dunkin-Hartley (DH) and Bristol strain 2 (BS2) guinea pigs at ages 
      of 1, 3, 6, 9, and 12 months were categorized into two groups and analyzed. The 
      bilateral TMJ condyles of DH and BS2 guinea pigs were harvested and fixed. The 
      distribution and expression profiles of CAD-11, collagen type II, and matrix 
      metalloproteinase 3 (MMP-3) were detected by immunohistological assays. 
      Histological micrographs of the condyle cartilage were obtained and analyzed. 
      RESULTS: Osteoarthritis can be spontaneously induced by mechanical stress in DH 
      guinea pigs. The main histopathological changes in the TMJ structure and 
      increased expression of MMP-3 occurred within 6-9 months of ages in DH guinea 
      pigs with spontaneous OA. By contrast, minimal to mild cartilage degradations 
      were observed in the TMJ of BS2 guinea pigs even at the age of 12 months. From as 
      early as 3 months of age, the expression levels of CAD-11 were upregulated in the 
      TMJ of DH guinea pigs compared with those in BS2 animals. CAD-11 expression 
      differed between the two groups at 12 months of age. CONCLUSIONS: Increased 
      CAD-11 expression within cartilage is associated with the development and 
      progression of OA between the two strains of guinea pigs. Therefore, CAD-11 
      expression in TMJ could be an important predisposing factor for the development 
      of spontaneous OA.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Wu, Mengjie
AU  - Wu M
AD  - Department of Orthodontics, Hospital of Stomatology, Zhejiang University, 
      Hangzhou, China.
FAU - Lu, Haiping
AU  - Lu H
AD  - School of Stomatology, Zhejiang Chinese Medical University, Hangzhou, China.
FAU - Yu, Fengyang
AU  - Yu F
AD  - School of Stomatology, Zhejiang Chinese Medical University, Hangzhou, China.
FAU - Zhou, Yiqun
AU  - Zhou Y
AD  - Department of Orthodontics, Hospital of Stomatology, Zhejiang University, 
      Hangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20151229
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
RN  - 0 (Cadherins)
RN  - 0 (Collagen Type II)
RN  - 156621-71-5 (osteoblast cadherin)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Cadherins/*biosynthesis
MH  - Cartilage/*metabolism/pathology
MH  - Collagen Type II/biosynthesis
MH  - Disease Models, Animal
MH  - Guinea Pigs
MH  - Immunohistochemistry
MH  - Mandibular Condyle
MH  - Matrix Metalloproteinase 3/biosynthesis
MH  - Osteoarthritis/*pathology
MH  - Stress, Mechanical
MH  - Temporomandibular Joint/*metabolism/pathology
MH  - Up-Regulation
OTO - NOTNLM
OT  - cadherin-11
OT  - cartilage degeneration
OT  - spontaneous osteoarthritis
OT  - temporomandibular joint
EDAT- 2015/12/30 06:00
MHDA- 2017/08/19 06:00
CRDT- 2015/12/30 06:00
PHST- 2015/11/18 00:00 [accepted]
PHST- 2015/12/30 06:00 [entrez]
PHST- 2015/12/30 06:00 [pubmed]
PHST- 2017/08/19 06:00 [medline]
AID - 10.1111/jop.12403 [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2016 Aug;45(7):534-8. doi: 10.1111/jop.12403. Epub 2015 Dec 
      29.