PMID- 2671111
OWN - NLM
STAT- MEDLINE
DCOM- 19891003
LR  - 20181113
IS  - 0391-4097 (Print)
IS  - 0391-4097 (Linking)
VI  - 12
IP  - 6
DP  - 1989 Jun
TI  - Insulin resistance in porphyria cutanea tarda.
PG  - 393-9
AB  - It has been reported that patients with porphyria cutanea tarda (PCT) develop 
      carbohydrate (CHO) intolerance and manifest diabetes melitus (DM) more frequently 
      than the normal population. In order to verify whether this is due to insulin 
      resistance we studied 5 patients with PCT and 5 normal subjects matched for age, 
      sex and weight. In all the patients an evaluation consisted of the glycemic curve 
      and insulin response to an iv glucose tolerance test (IVGTT: 0.33 g/kg) as well 
      as of an evaluation of the circulating monocyte insulin receptors. Blood samples 
      were drawn in the basal state to measure plasma levels of NEFA, glycerol, and 
      intermediate metabolites. The patients with PCT showed normal glucose tolerance 
      which was obtained, however, at the expense of the elevated insulin levels: 
      therefore a condition of insulin resistance was demonstrated in these subjects. 
      An involvement of the lipid metabolism, observed by the raised levels of plasma 
      NEFA and glycerol, was also evident. The insulin binding to circulating monocytes 
      was reduced but not enough to justify the degree of insulin resistance observed. 
      Therefore, it could be hypothesized, in agreement with similar studies, that a 
      postreceptor defect is responsible for the insulin-resistance observed in 
      patients with PCT and that the reduction of insulin receptors is determined by 
      the down regulation in response to elevated insulinemic levels. An alteration of 
      the porphyrin metabolism might be responsible for this disorder.
FAU - Calcinaro, F
AU  - Calcinaro F
AD  - Istituti di Patologia Speciale Medica, Universita di Perugia, Italy.
FAU - Basta, G
AU  - Basta G
FAU - Lisi, P
AU  - Lisi P
FAU - Cruciani, C
AU  - Cruciani C
FAU - Pietropaolo, M
AU  - Pietropaolo M
FAU - Santeusanio, F
AU  - Santeusanio F
FAU - Falorni, A Jr
AU  - Falorni A Jr
FAU - Calafiore, R
AU  - Calafiore R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Iodine Radioisotopes)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/metabolism
MH  - *Insulin Resistance
MH  - Iodine Radioisotopes
MH  - Male
MH  - Middle Aged
MH  - Monocytes/drug effects/metabolism
MH  - Porphyrias/*drug therapy/metabolism
MH  - Skin Diseases/*drug therapy/metabolism
EDAT- 1989/06/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1989/06/01 00:00
PHST- 1989/06/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1989/06/01 00:00 [entrez]
AID - 10.1007/BF03350708 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 1989 Jun;12(6):393-9. doi: 10.1007/BF03350708.