PMID- 26711124
OWN - NLM
STAT- MEDLINE
DCOM- 20160630
LR  - 20181113
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Linking)
VI  - 68
IP  - 3
DP  - 2016 Mar
TI  - The frequency of HLA alleles in the Romanian population.
PG  - 167-78
LID - 10.1007/s00251-015-0891-9 [doi]
AB  - Knowledge of human leukocyte antigen (HLA) allele frequencies is essential for 
      bone marrow and kidney donor searches. The Romanian Caucasian population is 
      heterogeneous and information on HLA polymorphism has not been well studied. We 
      characterized the HLA genetic profile and allele frequencies of regional 
      populations in Romania. HLA-A, B and DRB1 alleles were examined in 8252 
      individuals, belonging to the four main regions of Romania. The most common 
      alleles found in the Romanian population are the following: HLA-A*01, A*02, A*03, 
      A*11, A*24; HLA-B*18, B*35, B*44, B*51 and HLA-DRB1*01, DRB1*03, DRB1*07, 
      DRB1*11, DRB1*13, DRB1*15, DRB1*16. More than half of the alleles are 
      non-homogeneously spread in Romania. These results provide a starting point for 
      future analyses of genetic heterogeneity in Romania.
FAU - Constantinescu, Ileana
AU  - Constantinescu I
AD  - Department of Transplant Immunology, "Carol Davila" University of Medicine and 
      Pharmacy, Bucharest, Romania. ileana.constantinescu@imunogenetica.ro.
AD  - Centre for Immunogenetics, Fundeni Clinical Institute, Bucharest, Romania. 
      ileana.constantinescu@imunogenetica.ro.
FAU - Boscaiu, Voicu
AU  - Boscaiu V
AD  - "Gheorghe Mihoc-Caius Iacob" Institute of Mathematical Statistics and Applied 
      Mathematics, Bucharest, Romania.
FAU - Cianga, Petru
AU  - Cianga P
AD  - Laboratory of Immunology and Genetics, "Sf. Spiridon" Hospital, Iasi, Romania.
FAU - Dinu, Andrei-Antoniu
AU  - Dinu AA
AD  - Department of Transplant Immunology, "Carol Davila" University of Medicine and 
      Pharmacy, Bucharest, Romania.
AD  - Centre for Immunogenetics, Fundeni Clinical Institute, Bucharest, Romania.
FAU - Gai, Elena
AU  - Gai E
AD  - Centre for Immunophysiology and Biotechnology, "Victor Babes" University of 
      Medicine and Pharmacy, Timisoara, Romania.
FAU - Melinte, Mihaela
AU  - Melinte M
AD  - Centre for Immunogenetics, Emergency Institute for Cardiovascular Diseases and 
      Transplantation, Targu-Mures, Romania.
FAU - Moise, Ana
AU  - Moise A
AD  - Department of Transplant Immunology, "Carol Davila" University of Medicine and 
      Pharmacy, Bucharest, Romania.
AD  - Centre for Immunogenetics, Fundeni Clinical Institute, Bucharest, Romania.
LA  - eng
PT  - Journal Article
DEP - 20151228
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Alleles
MH  - Cluster Analysis
MH  - *Gene Frequency
MH  - Genetic Linkage
MH  - *Genetics, Population
MH  - Geography
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - Principal Component Analysis
MH  - Romania
OTO - NOTNLM
OT  - Allele frequency
OT  - HLA polymorphism
OT  - Human leukocyte antigen (HLA)
OT  - Population studies
EDAT- 2015/12/30 06:00
MHDA- 2016/07/01 06:00
CRDT- 2015/12/30 06:00
PHST- 2015/12/09 00:00 [received]
PHST- 2015/12/10 00:00 [accepted]
PHST- 2015/12/30 06:00 [entrez]
PHST- 2015/12/30 06:00 [pubmed]
PHST- 2016/07/01 06:00 [medline]
AID - 10.1007/s00251-015-0891-9 [pii]
AID - 10.1007/s00251-015-0891-9 [doi]
PST - ppublish
SO  - Immunogenetics. 2016 Mar;68(3):167-78. doi: 10.1007/s00251-015-0891-9. Epub 2015 
      Dec 28.