PMID- 26711207
OWN - NLM
STAT- MEDLINE
DCOM- 20160407
LR  - 20181202
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 95
IP  - 30
DP  - 2015 Aug 11
TI  - [Association of vitamin D receptor ApaI and TaqI gene polymorphisms with 
      pigmented pretibial patches in T2DM patients].
PG  - 2451-4
AB  - OBJECTIVE: To explore the association of vitamin D receptor ApaI and TaqI gene 
      polymorphisms with pigmented pretibial patches (PPPs) in type 2 diabetes mellitus 
      (T2DM) patients. METHODS: A total of 233 patients with T2DM were enrolled. 
      Patients were assigned to PPPs group (n=106) or non-PPPs (n=127) according to the 
      presence of PPPs. Allelic and genotypic comparisons of VDR-TaqI and VDR-ApaI 
      between the different groups were evaluated by polymerase chain 
      reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: The 
      genotype and allele gene frequency were similar at ApaI in two groups (P>0.05). 
      The PPPs group showed a higher frequency of TT allele at TaqI in the T2DM (95%) 
      when compared to that of non-PPPs group (87%), while the frequency of Tt and tt 
      allele were lower in PPPs group than non-PPPs group in T2DM (5% vs 13%, all 
      P<0.05). The frequency of T allele were higher at TaqI in PPPs group (98%) than 
      non-PPPs group (93%) in T2DM, while PPPs had a lower frequency of t allele (2% vs 
      7%, all P<0.05). CONCLUSION: It seems that gene polymorphisms of VDR-TaqI, not 
      VDR-ApaI, contributes to the risk of PPPs in T2DM patients in the Han nationality 
      in Tianjin area.
FAU - Su, Wenling
AU  - Su W
AD  - Department of Endocrinology, Tianjin Medical University General Hospital, Tianjin 
      300052, China; Email: SWL13820515519@163.com.
FAU - Qiu, Mingcai
AU  - Qiu M
AD  - Department of Endocrinology, Tianjin Medical University General Hospital, Tianjin 
      300052, China.
FAU - Dai, Bin
AU  - Dai B
AD  - Department of Endocrinology, Tianjin Medical University General Hospital, Tianjin 
      300052, China.
FAU - Zhang, Peng
AU  - Zhang P
AD  - Department of Endocrinology, Tianjin Medical University General Hospital, Tianjin 
      300052, China.
FAU - Tang, Shaofang
AU  - Tang S
AD  - Department of Endocrinology, Tianjin Medical University General Hospital, Tianjin 
      300052, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Receptors, Calcitriol)
SB  - IM
MH  - Alleles
MH  - *Diabetes Mellitus, Type 2
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Restriction Fragment Length
MH  - Receptors, Calcitriol
EDAT- 2015/12/30 06:00
MHDA- 2016/04/08 06:00
CRDT- 2015/12/30 06:00
PHST- 2015/12/30 06:00 [entrez]
PHST- 2015/12/30 06:00 [pubmed]
PHST- 2016/04/08 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2015 Aug 11;95(30):2451-4.