PMID- 26711489
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20181202
IS  - 1879-0887 (Electronic)
IS  - 0167-8140 (Linking)
VI  - 118
IP  - 1
DP  - 2016 Jan
TI  - Evaluation of adverse events in atomic bomb survivors receiving curative-intent 
      radiation therapy from 2005 to 2010.
PG  - 60-4
LID - S0167-8140(15)00644-1 [pii]
LID - 10.1016/j.radonc.2015.11.024 [doi]
AB  - BACKGROUND AND PURPOSE: To evaluate the safety of radiation therapy (RT) in 
      atomic bomb (A-bomb) survivors (ABS), we evaluated the frequency of RT-associated 
      adverse events (AEs) in ABS. MATERIALS AND METHODS: We selected patients who 
      underwent curative external-beam RT (EBRT) at Hiroshima University Hospital 
      between January 2005 and December 2010 and were born before August 1946; the 
      patients were divided into ABS and non-ABS groups, which groups received 
      identical treatments without stratification. RESULTS: We retrospectively reviewed 
      the medical records of 220 ABS and 753 non-ABS patients. The median age was 72 
      years. The median observation durations were 41 and 37 months for the ABS and 
      non-ABS groups, respectively. The ABS group had higher frequencies of women, 
      breast cancer patients, and concurrent chemotherapy and had a lower incidence of 
      only acute hematological AEs. However this tendency disappeared when breast 
      cancer patients were excluded, and no significant differences were observed 
      between the ABS and non-ABS groups regarding Grade ⩾ 3 other acute and late AEs. 
      The overall cumulative incidence of Grade ⩾ 3 late AEs did not significantly 
      differ between the ABS and non-ABS groups. CONCLUSIONS: Notable increases in AEs 
      were not observed during or after RT among ABS. This study clarified that 
      stratification is not required when treating ABS with RT.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Doi, Yoshiko
AU  - Doi Y
AD  - Department of Radiation Oncology, Graduate School of Biomedical Sciences, 
      Hiroshima University, Japan. Electronic address: yoshikod@hiroshima-u.ac.jp.
FAU - Murakami, Yuji
AU  - Murakami Y
AD  - Department of Radiation Oncology, Graduate School of Biomedical Sciences, 
      Hiroshima University, Japan.
FAU - Kenjo, Masahiro
AU  - Kenjo M
AD  - Department of Radiation Oncology, Graduate School of Biomedical Sciences, 
      Hiroshima University, Japan.
FAU - Imano, Nobuki
AU  - Imano N
AD  - Department of Radiation Oncology, Graduate School of Biomedical Sciences, 
      Hiroshima University, Japan.
FAU - Kimura, Tomoki
AU  - Kimura T
AD  - Department of Radiation Oncology, Graduate School of Biomedical Sciences, 
      Hiroshima University, Japan.
FAU - Nagata, Yasushi
AU  - Nagata Y
AD  - Department of Radiation Oncology, Graduate School of Biomedical Sciences, 
      Hiroshima University, Japan.
LA  - eng
PT  - Journal Article
DEP - 20151219
PL  - Ireland
TA  - Radiother Oncol
JT  - Radiotherapy and oncology : journal of the European Society for Therapeutic 
      Radiology and Oncology
JID - 8407192
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*mortality/*radiotherapy
MH  - *Nuclear Weapons
MH  - Retrospective Studies
MH  - Survivors/*statistics & numerical data
OTO - NOTNLM
OT  - Adverse events
OT  - Atomic bomb survivors
OT  - Radiation therapy
EDAT- 2015/12/30 06:00
MHDA- 2016/10/14 06:00
CRDT- 2015/12/30 06:00
PHST- 2014/11/13 00:00 [received]
PHST- 2015/11/26 00:00 [accepted]
PHST- 2015/12/30 06:00 [entrez]
PHST- 2015/12/30 06:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
AID - S0167-8140(15)00644-1 [pii]
AID - 10.1016/j.radonc.2015.11.024 [doi]
PST - ppublish
SO  - Radiother Oncol. 2016 Jan;118(1):60-4. doi: 10.1016/j.radonc.2015.11.024. Epub 
      2015 Dec 19.