PMID- 26711526 OWN - NLM STAT- MEDLINE DCOM- 20161102 LR - 20161230 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 170 IP - 1 DP - 2016 Jan TI - Impulsivity across the psychosis spectrum: Correlates of cortical volume, suicidal history, and social and global function. PG - 80-6 LID - S0920-9964(15)30073-6 [pii] LID - 10.1016/j.schres.2015.11.030 [doi] AB - Patients with psychotic disorders appear to exhibit greater impulsivity-related behaviors relative to healthy controls. However, the neural underpinning of this impulsivity remains uncertain. Furthermore, it remains unclear how impulsivity might differ or be conserved between psychotic disorder diagnoses in mechanism and manifestation. In this study, self-reported impulsivity, measured by Barratt Impulsiveness Scale (BIS), was compared between 305 controls (HC), 139 patients with schizophrenia (SZ), 100 with schizoaffective disorder (SZA), and 125 with psychotic bipolar disorder (PBP). In each proband group, impulsivity was associated with regional cortical volumes (using FreeSurfer analysis of T1 MRI scans), suicide attempt history, Global Assessment of Functioning (GAF), and Social Functioning Scale (SFS). BIS scores were found to differ significantly between participant groups, with SZA and PBP exhibiting significantly higher impulsivity than SZ, which exhibited significantly higher impulsivity than HC. BIS scores were significantly related to suicide attempt history, and they were inversely associated with GAF, SFS, and bilateral orbitofrontal cortex (OFC) volume in both SZA and PBP, but not SZ. These findings indicate that psychotic disorders, particularly those with prominent affective symptoms, are characterized by elevated self-reported impulsivity measures. Impulsivity's correlations with suicide attempt history, GAF, and SFS suggest that impulsivity may be a mediator of clinical outcome. The observed impulsivity-OFC correlations corroborate the importance of OFC deficits in impulsivity. These correlations' presence in SZA and PBP but not in SZ suggests that impulsivity may have different underlying mechanisms in affective and non-affective psychotic disorders. CI - Copyright (c) 2015 Elsevier B.V. All rights reserved. FAU - Nanda, Pranav AU - Nanda P AD - College of Physicians & Surgeons, Columbia University Medical Center, New York, NY, USA. FAU - Tandon, Neeraj AU - Tandon N AD - Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Baylor College of Medicine, Texas Medical Center, Houston, TX, USA. FAU - Mathew, Ian T AU - Mathew IT AD - Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA. FAU - Padmanabhan, Jaya L AU - Padmanabhan JL AD - Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Neurology, McLean Hospital, Belmont, MA, USA. FAU - Clementz, Brett A AU - Clementz BA AD - Department of Psychology, BioImaging Research Center, University of Georgia, Athens, GA, USA; Department of Neuroscience, BioImaging Research Center, University of Georgia, Athens, GA, USA. FAU - Pearlson, Godfrey D AU - Pearlson GD AD - Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA; Departments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, CT, USA. FAU - Sweeney, John A AU - Sweeney JA AD - Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. FAU - Tamminga, Carol A AU - Tamminga CA AD - Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. FAU - Keshavan, Matcheri S AU - Keshavan MS AD - Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address: mkeshava@bidmc.harvard.edu. LA - eng GR - MH077862/MH/NIMH NIH HHS/United States GR - MH077852/MH/NIMH NIH HHS/United States GR - MH078113/MH/NIMH NIH HHS/United States GR - MH077851/MH/NIMH NIH HHS/United States GR - MH083888/MH/NIMH NIH HHS/United States GR - MH077945/MH/NIMH NIH HHS/United States GR - R01 MH078113/MH/NIMH NIH HHS/United States GR - MH072767/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20151223 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Adult MH - Bipolar Disorder/pathology/psychology MH - Cerebral Cortex/*pathology MH - Female MH - Humans MH - *Impulsive Behavior MH - Magnetic Resonance Imaging MH - Male MH - Organ Size MH - Psychiatric Status Rating Scales MH - Psychotic Disorders/*pathology/*psychology MH - Schizophrenia/pathology MH - Schizophrenic Psychology MH - Self Report MH - Suicide, Attempted/*psychology OTO - NOTNLM OT - Cortical volume OT - Impulsivity OT - Orbitofrontal cortex OT - Psychosis spectrum OT - Psychotic disorders EDAT- 2015/12/30 06:00 MHDA- 2016/11/03 06:00 CRDT- 2015/12/30 06:00 PHST- 2015/08/07 00:00 [received] PHST- 2015/11/24 00:00 [revised] PHST- 2015/11/30 00:00 [accepted] PHST- 2015/12/30 06:00 [entrez] PHST- 2015/12/30 06:00 [pubmed] PHST- 2016/11/03 06:00 [medline] AID - S0920-9964(15)30073-6 [pii] AID - 10.1016/j.schres.2015.11.030 [doi] PST - ppublish SO - Schizophr Res. 2016 Jan;170(1):80-6. doi: 10.1016/j.schres.2015.11.030. Epub 2015 Dec 23.