PMID- 26711603
OWN - NLM
STAT- MEDLINE
DCOM- 20160330
LR  - 20221207
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 95
IP  - 32
DP  - 2015 Aug 25
TI  - [Association between retinopathy and sleep disorder in patients with type 2 
      diabetes mellitus].
PG  - 2579-83
AB  - OBJECTIVE: To explore the association between retinopathy and sleep disorder in 
      patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 440 patients 
      with T2DM treated from July 2011 to July 2013 in Metabolic Disease Hospital of 
      Tianjin Medical University were divided into 2 groups according to Pittsburgh 
      Sleep Quality Index: non-sleep disorder group (258 cases) and sleep disorder 
      group (182 cases). Biochemical parameters including hepatorenal function, blood 
      lipids, glycosylated hemoglobin (HbA1c), fructosamine and hemorrheology were 
      detected. Oral glucose tolerance test, insulin releasing test and glucagon 
      releasing test were performed to detect the inteR-group differences of alpha-cell and 
      beta-cell function after fasting and glucose-load management. The logistic 
      regression analysis was performed to identify the factors relevant to 
      retinopathy. RESULTS: The ratio of retinopathy was 42.9% in sleep disorder group, 
      which was higher compared to those in non-sleep disorder group (32.6%), P=0.027. 
      The levels of fasting plasma glucose, postprandial blood glucose, HbA1c, 
      fructosamine, systolic blood pressure, diastolic blood pressure and the 
      indicators of hemorrheology (plasma viscosity, erythrocyte aggregation index, 
      erythrocyte rigidity index, fibrinogen) were significantly higher in patients 
      with sleep disorder compared to those without sleep disorder, while the 
      erythrocyte defomation index was significantly lower in sleep disorder group (all 
      P<0.05). The levels of glucagon and glucagon/insulin ratio at each time point as 
      well as area under curve of glucagon were significantly higher in sleep disorder 
      group (all P<0.05). The levels of fasting insulin, homeostasis model assessment 
      for insulin resistance index (HOMA-IR) and area under curve of insulin were 
      significantly higher in patients with sleep disorder compared to those without 
      sleep disorder, while insulin sensitivity index was lower in patients with sleep 
      disorder (all P<0.05). Logistic regression analysis showed that retinopathy was 
      positively related to HbA1c (OR: 1.744-3.249), fibrinogen (OR: 1.687-2.998), 
      systolic blood pressure (OR: 1.152-2.013), HOMA-IR (OR: 1.006-1.389) and sleep 
      disorder (OR: 1.144-2.426), and negatively related to insulin sensitivity index 
      (OR: 0.107-0.784) (all P<0.05). CONCLUSION: Sleep disorders may be associated 
      with retinopathy through multiple mechanisms in patients with T2DM.
FAU - Ren, Huizhu
AU  - Ren H
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Metabolic 
      Disease Hospital & Tianjin Institute of Endocrinology, Tianjin Medical 
      University, Tianjin 300070, China.
FAU - Xu, Yanguang
AU  - Xu Y
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Metabolic 
      Disease Hospital & Tianjin Institute of Endocrinology, Tianjin Medical 
      University, Tianjin 300070, China.
FAU - Chang, Baocheng
AU  - Chang B
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Metabolic 
      Disease Hospital & Tianjin Institute of Endocrinology, Tianjin Medical 
      University, Tianjin 300070, China.
FAU - Yang, Juhong
AU  - Yang J
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Metabolic 
      Disease Hospital & Tianjin Institute of Endocrinology, Tianjin Medical 
      University, Tianjin 300070, China.
FAU - Zheng, Miaoyan
AU  - Zheng M
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Metabolic 
      Disease Hospital & Tianjin Institute of Endocrinology, Tianjin Medical 
      University, Tianjin 300070, China.
FAU - Yang, Yanhui
AU  - Yang Y
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Metabolic 
      Disease Hospital & Tianjin Institute of Endocrinology, Tianjin Medical 
      University, Tianjin 300070, China.
FAU - Cheng, Jingli
AU  - Cheng J
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Metabolic 
      Disease Hospital & Tianjin Institute of Endocrinology, Tianjin Medical 
      University, Tianjin 300070, China.
FAU - Shan, Chunyan
AU  - Shan C
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Metabolic 
      Disease Hospital & Tianjin Institute of Endocrinology, Tianjin Medical 
      University, Tianjin 300070, China; Email: chunyanshan@hotmail.com.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Type 2
MH  - Glucagon
MH  - *Glucose Tolerance Test
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Insulin
MH  - Insulin Resistance
MH  - Insulin-Secreting Cells
MH  - Postprandial Period
MH  - *Sleep Wake Disorders
EDAT- 2015/12/30 06:00
MHDA- 2016/03/31 06:00
CRDT- 2015/12/30 06:00
PHST- 2015/12/30 06:00 [entrez]
PHST- 2015/12/30 06:00 [pubmed]
PHST- 2016/03/31 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2015 Aug 25;95(32):2579-83.