PMID- 26712159
OWN - NLM
STAT- MEDLINE
DCOM- 20160502
LR  - 20220321
IS  - 1942-0080 (Electronic)
IS  - 1941-9651 (Print)
IS  - 1941-9651 (Linking)
VI  - 9
IP  - 1
DP  - 2016 Jan
TI  - Comparison of Echocardiographic Measures in a Hispanic/Latino Population With the 
      2005 and 2015 American Society of Echocardiography Reference Limits (The 
      Echocardiographic Study of Latinos).
LID - 10.1161/CIRCIMAGING.115.003597 [doi]
LID - 10.1161/CIRCIMAGING.115.003597 e003597
AB  - BACKGROUND: Reference limits for echocardiographic quantification of cardiac 
      chambers in Hispanics are not well studied. METHODS AND RESULTS: We examined the 
      reference values of left atrium and left ventricle (LV) structure in a large 
      ethnically diverse Hispanic cohort. Two-dimensional transthoracic 
      echocardiography was performed in 1818 participants of the Echocardiographic 
      Study of Latinos (ECHO-SOL). Individuals with body mass index >/=30 kg/m(2), 
      hypertension, diabetes mellitus, coronary artery disease, and atrial fibrillation 
      were excluded leaving 525 participants defined as healthy reference cohort. We 
      estimated 95th weighted percentiles of LV end systolic volume, LV end diastolic 
      volume, relative wall and septal thickness, LV mass, and left atrial volume. We 
      then used upper reference limits of the 2005 and 2015 American Society of 
      Echocardiography (ASE) and 95th percentile of reference cohort to classify the 
      Hispanic Community Health Study/Study of Latinos (HCHS/SOL) target population 
      into abnormal and normal. Reference limits were also calculated for each of 6 
      Hispanic origins. Using ASE 2015 defined reference values, we categorized 7%, 
      21%, 57%, and 17% of men and 18%, 29%, 60%, and 26% of women as having abnormal 
      LV mass index, relative, septal, and posterior wall thickness, respectively. 
      Conversely, 10% and 11% of men and 4% and 2% of women were classified as having 
      abnormal end-diastolic volume and internal diameter by ASE 2015 cutoffs, 
      respectively. Similar differences were found when we used 2005 ASE cutoffs. 
      Several differences were noted in distribution of cardiac structure and volumes 
      among various Hispanic/Latino origins. Cubans had highest values of 
      echocardiographic measures, and Central Americans had the lowest. CONCLUSIONS: 
      This is the first large study that provides normal reference values for cardiac 
      structure. It further demonstrates that a considerable segment of 
      Hispanic/Latinos residing in the United States may be classified as having 
      abnormal measures of cardiac chambers when 2015 and 2005 ASE reference cutoffs 
      are used.
CI  - (c) 2015 American Heart Association, Inc.
FAU - Qureshi, Waqas T
AU  - Qureshi WT
AD  - From the Departments of Internal Medicine (W.T.Q., J.A.L., A.D., C.J.R.) and 
      Public Health Sciences (K.S., C.J.R.), Wake Forest School of Medicine, 
      Winston-Salem, NC; San Diego School of Medicine, University of California 
      (M.A.A.); Department of Biostatistics, Gillings School of Global Public Health, 
      University of North Carolina, Chapel Hill (J.C., F.G.); Department of Psychology, 
      University of Miami, FL (B.E.H.); Department of Medicine - Cardiology, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL (S.J.S.); Department of 
      Medicine, University of Arizona, Tucson (A.A.D.); and Department of Medicine, 
      Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY (D.M.S.). 
      wquershi@wakehealth.edu.
FAU - Leigh, J Adam
AU  - Leigh JA
AD  - From the Departments of Internal Medicine (W.T.Q., J.A.L., A.D., C.J.R.) and 
      Public Health Sciences (K.S., C.J.R.), Wake Forest School of Medicine, 
      Winston-Salem, NC; San Diego School of Medicine, University of California 
      (M.A.A.); Department of Biostatistics, Gillings School of Global Public Health, 
      University of North Carolina, Chapel Hill (J.C., F.G.); Department of Psychology, 
      University of Miami, FL (B.E.H.); Department of Medicine - Cardiology, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL (S.J.S.); Department of 
      Medicine, University of Arizona, Tucson (A.A.D.); and Department of Medicine, 
      Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY (D.M.S.).
FAU - Swett, Katrina
AU  - Swett K
AD  - From the Departments of Internal Medicine (W.T.Q., J.A.L., A.D., C.J.R.) and 
      Public Health Sciences (K.S., C.J.R.), Wake Forest School of Medicine, 
      Winston-Salem, NC; San Diego School of Medicine, University of California 
      (M.A.A.); Department of Biostatistics, Gillings School of Global Public Health, 
      University of North Carolina, Chapel Hill (J.C., F.G.); Department of Psychology, 
      University of Miami, FL (B.E.H.); Department of Medicine - Cardiology, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL (S.J.S.); Department of 
      Medicine, University of Arizona, Tucson (A.A.D.); and Department of Medicine, 
      Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY (D.M.S.).
FAU - Dharod, Ajay
AU  - Dharod A
AD  - From the Departments of Internal Medicine (W.T.Q., J.A.L., A.D., C.J.R.) and 
      Public Health Sciences (K.S., C.J.R.), Wake Forest School of Medicine, 
      Winston-Salem, NC; San Diego School of Medicine, University of California 
      (M.A.A.); Department of Biostatistics, Gillings School of Global Public Health, 
      University of North Carolina, Chapel Hill (J.C., F.G.); Department of Psychology, 
      University of Miami, FL (B.E.H.); Department of Medicine - Cardiology, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL (S.J.S.); Department of 
      Medicine, University of Arizona, Tucson (A.A.D.); and Department of Medicine, 
      Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY (D.M.S.).
FAU - Allison, Matthew A
AU  - Allison MA
AD  - From the Departments of Internal Medicine (W.T.Q., J.A.L., A.D., C.J.R.) and 
      Public Health Sciences (K.S., C.J.R.), Wake Forest School of Medicine, 
      Winston-Salem, NC; San Diego School of Medicine, University of California 
      (M.A.A.); Department of Biostatistics, Gillings School of Global Public Health, 
      University of North Carolina, Chapel Hill (J.C., F.G.); Department of Psychology, 
      University of Miami, FL (B.E.H.); Department of Medicine - Cardiology, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL (S.J.S.); Department of 
      Medicine, University of Arizona, Tucson (A.A.D.); and Department of Medicine, 
      Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY (D.M.S.).
FAU - Cai, Jianwen
AU  - Cai J
AD  - From the Departments of Internal Medicine (W.T.Q., J.A.L., A.D., C.J.R.) and 
      Public Health Sciences (K.S., C.J.R.), Wake Forest School of Medicine, 
      Winston-Salem, NC; San Diego School of Medicine, University of California 
      (M.A.A.); Department of Biostatistics, Gillings School of Global Public Health, 
      University of North Carolina, Chapel Hill (J.C., F.G.); Department of Psychology, 
      University of Miami, FL (B.E.H.); Department of Medicine - Cardiology, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL (S.J.S.); Department of 
      Medicine, University of Arizona, Tucson (A.A.D.); and Department of Medicine, 
      Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY (D.M.S.).
FAU - Gonzalez, Franklyn 2nd
AU  - Gonzalez F 2nd
AD  - From the Departments of Internal Medicine (W.T.Q., J.A.L., A.D., C.J.R.) and 
      Public Health Sciences (K.S., C.J.R.), Wake Forest School of Medicine, 
      Winston-Salem, NC; San Diego School of Medicine, University of California 
      (M.A.A.); Department of Biostatistics, Gillings School of Global Public Health, 
      University of North Carolina, Chapel Hill (J.C., F.G.); Department of Psychology, 
      University of Miami, FL (B.E.H.); Department of Medicine - Cardiology, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL (S.J.S.); Department of 
      Medicine, University of Arizona, Tucson (A.A.D.); and Department of Medicine, 
      Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY (D.M.S.).
FAU - Hurwitz, Barry E
AU  - Hurwitz BE
AD  - From the Departments of Internal Medicine (W.T.Q., J.A.L., A.D., C.J.R.) and 
      Public Health Sciences (K.S., C.J.R.), Wake Forest School of Medicine, 
      Winston-Salem, NC; San Diego School of Medicine, University of California 
      (M.A.A.); Department of Biostatistics, Gillings School of Global Public Health, 
      University of North Carolina, Chapel Hill (J.C., F.G.); Department of Psychology, 
      University of Miami, FL (B.E.H.); Department of Medicine - Cardiology, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL (S.J.S.); Department of 
      Medicine, University of Arizona, Tucson (A.A.D.); and Department of Medicine, 
      Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY (D.M.S.).
FAU - Shah, Sanjiv J
AU  - Shah SJ
AD  - From the Departments of Internal Medicine (W.T.Q., J.A.L., A.D., C.J.R.) and 
      Public Health Sciences (K.S., C.J.R.), Wake Forest School of Medicine, 
      Winston-Salem, NC; San Diego School of Medicine, University of California 
      (M.A.A.); Department of Biostatistics, Gillings School of Global Public Health, 
      University of North Carolina, Chapel Hill (J.C., F.G.); Department of Psychology, 
      University of Miami, FL (B.E.H.); Department of Medicine - Cardiology, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL (S.J.S.); Department of 
      Medicine, University of Arizona, Tucson (A.A.D.); and Department of Medicine, 
      Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY (D.M.S.).
FAU - Desai, Ankit A
AU  - Desai AA
AD  - From the Departments of Internal Medicine (W.T.Q., J.A.L., A.D., C.J.R.) and 
      Public Health Sciences (K.S., C.J.R.), Wake Forest School of Medicine, 
      Winston-Salem, NC; San Diego School of Medicine, University of California 
      (M.A.A.); Department of Biostatistics, Gillings School of Global Public Health, 
      University of North Carolina, Chapel Hill (J.C., F.G.); Department of Psychology, 
      University of Miami, FL (B.E.H.); Department of Medicine - Cardiology, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL (S.J.S.); Department of 
      Medicine, University of Arizona, Tucson (A.A.D.); and Department of Medicine, 
      Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY (D.M.S.).
FAU - Spevack, Daniel M
AU  - Spevack DM
AD  - From the Departments of Internal Medicine (W.T.Q., J.A.L., A.D., C.J.R.) and 
      Public Health Sciences (K.S., C.J.R.), Wake Forest School of Medicine, 
      Winston-Salem, NC; San Diego School of Medicine, University of California 
      (M.A.A.); Department of Biostatistics, Gillings School of Global Public Health, 
      University of North Carolina, Chapel Hill (J.C., F.G.); Department of Psychology, 
      University of Miami, FL (B.E.H.); Department of Medicine - Cardiology, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL (S.J.S.); Department of 
      Medicine, University of Arizona, Tucson (A.A.D.); and Department of Medicine, 
      Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY (D.M.S.).
FAU - Rodriguez, Carlos J
AU  - Rodriguez CJ
AD  - From the Departments of Internal Medicine (W.T.Q., J.A.L., A.D., C.J.R.) and 
      Public Health Sciences (K.S., C.J.R.), Wake Forest School of Medicine, 
      Winston-Salem, NC; San Diego School of Medicine, University of California 
      (M.A.A.); Department of Biostatistics, Gillings School of Global Public Health, 
      University of North Carolina, Chapel Hill (J.C., F.G.); Department of Psychology, 
      University of Miami, FL (B.E.H.); Department of Medicine - Cardiology, Feinberg 
      School of Medicine, Northwestern University, Chicago, IL (S.J.S.); Department of 
      Medicine, University of Arizona, Tucson (A.A.D.); and Department of Medicine, 
      Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY (D.M.S.).
LA  - eng
GR  - T32 HL076132/HL/NHLBI NIH HHS/United States
GR  - R01 HL104199/HL/NHLBI NIH HHS/United States
GR  - N01HC65236/HL/NHLBI NIH HHS/United States
GR  - N01HC65235/HL/NHLBI NIH HHS/United States
GR  - N01-HC65237/HC/NHLBI NIH HHS/United States
GR  - N01HC65234/HL/NHLBI NIH HHS/United States
GR  - N01HC65233/HL/NHLBI NIH HHS/United States
GR  - N01HC65237/HL/NHLBI NIH HHS/United States
GR  - N01-HC65233/HC/NHLBI NIH HHS/United States
GR  - N01-HC65234/HC/NHLBI NIH HHS/United States
GR  - N01-HC65236/HC/NHLBI NIH HHS/United States
GR  - N01-HC65235/HC/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Circ Cardiovasc Imaging
JT  - Circulation. Cardiovascular imaging
JID - 101479935
SB  - IM
CIN - Circ Cardiovasc Imaging. 2016 Jan;9(1). pii: e004256. doi: 
      10.1161/CIRCIMAGING.115.004256. PMID: 26712161
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Echocardiography/*methods
MH  - Female
MH  - Heart Atria/*diagnostic imaging
MH  - Heart Ventricles/*diagnostic imaging
MH  - *Hispanic or Latino
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reference Values
PMC - PMC4696402
MID - NIHMS737335
OTO - NOTNLM
OT  - Hispanic Americans
OT  - echocardiography
OT  - ethnology
OT  - heart atria
OT  - heart ventricle
EDAT- 2015/12/30 06:00
MHDA- 2016/05/03 06:00
PMCR- 2017/01/01
CRDT- 2015/12/30 06:00
PHST- 2015/12/30 06:00 [entrez]
PHST- 2015/12/30 06:00 [pubmed]
PHST- 2016/05/03 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - CIRCIMAGING.115.003597 [pii]
AID - 10.1161/CIRCIMAGING.115.003597 [doi]
PST - ppublish
SO  - Circ Cardiovasc Imaging. 2016 Jan;9(1):10.1161/CIRCIMAGING.115.003597 e003597. 
      doi: 10.1161/CIRCIMAGING.115.003597.