PMID- 26712871
OWN - NLM
STAT- MEDLINE
DCOM- 20160505
LR  - 20151229
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 145
IP  - 1
DP  - 2016 Jan
TI  - FGFR1 Amplification in Squamous Cell Carcinoma of the Lung with Correlation of 
      Primary and Metastatic Tumor Status.
PG  - 55-61
LID - 10.1093/ajcp/aqv013 [doi]
AB  - BACKGROUND: The FGFR1 gene can be amplified in squamous cell carcinoma of the 
      lung (SqCC). The aim of this study was to compare FGFR1 status with stage and 
      matched primaries with metastases. METHODS: Cases with FGFR1 fluorescence in situ 
      hybridization (FISH) testing performed from 2000 to 2013 were evaluated for 
      amplification status and clinicopathologic features. RESULTS: Of the 336 cases 
      tested by FGFR1 FISH, 52 (15%) were positive for amplification. Eight (13%) of 60 
      N0 cases and eight (17%) of 46 N1 or N2 cases were amplified, with no 
      statistically significant difference. Of the 24 cases with matched primary and 
      metastatic tumors, 22 (92%) were synchronous and one (4%) had discordant 
      amplification. CONCLUSIONS: Frequency of FGFR1 amplification is similar in SqCC 
      with and without lymph node metastases, but status in metastatic sites may be 
      discordant from the primary in a small subset of cases, which may affect the 
      decision to perform testing of metastatic SqCCs.
CI  - (c) American Society for Clinical Pathology, 2016. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Monaco, Sara E
AU  - Monaco SE
AD  - From the Department of Pathology, University of Pittsburgh Medical Center, 
      Pittsburgh, PA. monacose@upmc.edu.
FAU - Rodriguez, Erika F
AU  - Rodriguez EF
AD  - From the Department of Pathology, University of Pittsburgh Medical Center, 
      Pittsburgh, PA.
FAU - Mahaffey, Alyssa L
AU  - Mahaffey AL
AD  - From the Department of Pathology, University of Pittsburgh Medical Center, 
      Pittsburgh, PA.
FAU - Dacic, Sanja
AU  - Dacic S
AD  - From the Department of Pathology, University of Pittsburgh Medical Center, 
      Pittsburgh, PA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - EC 2.7.10.1 (FGFR1 protein, human)
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/pathology
MH  - Female
MH  - *Gene Amplification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/*genetics/metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Receptor, Fibroblast Growth Factor, Type 1/*genetics/metabolism
MH  - Young Adult
OTO - NOTNLM
OT  - FGFR
OT  - Fibroblast growth factor
OT  - Lung
OT  - Squamous cell carcinoma
EDAT- 2015/12/30 06:00
MHDA- 2016/05/06 06:00
CRDT- 2015/12/30 06:00
PHST- 2015/12/30 06:00 [entrez]
PHST- 2015/12/30 06:00 [pubmed]
PHST- 2016/05/06 06:00 [medline]
AID - aqv013 [pii]
AID - 10.1093/ajcp/aqv013 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2016 Jan;145(1):55-61. doi: 10.1093/ajcp/aqv013.