PMID- 26712881
OWN - NLM
STAT- MEDLINE
DCOM- 20160505
LR  - 20151229
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 145
IP  - 1
DP  - 2016 Jan
TI  - Matrix Metalloproteinase 3 Gene Polymorphism and Its Level Predict Morbidity 
      After Acute Myocardial Infarction.
PG  - 134-9
LID - 10.1093/ajcp/aqv008 [doi]
AB  - OBJECTIVES: Matrix metalloproteinase is responsible for ventricular remodeling 
      after acute myocardial infarction (MI). The purpose of the present study was to 
      determine whether the matrix metalloproteinase 3 (MMP-3) polymorphism and its 
      level predict morbidity after acute MI (AMI). METHODS: We studied 112 patients 
      with AMI and 140 controls. All patients were followed for AMI complications 
      during their hospitalization and 6 months after. Serum MMP-3 was measured. 
      MMP-3-1612 5A/6A polymorphism was genotyped by polymerase chain reaction. 
      RESULTS: We observed that the serum MMP-3 levels were significantly increased in 
      patients with AMI with morbidity compared with patients without complications. 
      Also, MMP-3 levels in patients with AMI carrying 5A/5A were elevated compared 
      with those carrying 6A/6A. The frequencies of 5A/5A genotypes were significantly 
      increased in patients with AMI compared with controls, and patients with AMI 
      carrying 5A/5A had a fivefold increased risk of developing morbidity. The 
      impairment of left ventricular function (DeltaFS [fractional shortening] and DeltaEF 
      [ejection fraction]) was observed more in the 5A/5A genotype compared with the 
      6A/6A genotype. A significant inverse correlation between predischarge MMP-3 
      levels and FS and EF was found at 6 months follow-up. CONCLUSIONS: MMP-3 
      polymorphism has a significant association with the risk of developing morbidity 
      after AMI. Higher predischarge MMP-3 levels are associated with left ventricular 
      dysfunction after AMI.
CI  - (c) American Society for Clinical Pathology, 2016. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Abd El-Aziz, Tarek A
AU  - Abd El-Aziz TA
AD  - From the Cardiology Department.
FAU - Mohamed, Randa H
AU  - Mohamed RH
AD  - Medical Biochemistry Department, Faculty of Medicine, Zagazig University, 
      Zagazig, Egypt. randahussiny@yahoo.com.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood/*genetics
MH  - Middle Aged
MH  - Myocardial Infarction/blood/genetics/*mortality
MH  - *Polymorphism, Single Nucleotide
MH  - Prognosis
MH  - Promoter Regions, Genetic
MH  - Risk Factors
OTO - NOTNLM
OT  - MMP-3
OT  - Morbidity
OT  - Polymorphisms
OT  - Predictors
EDAT- 2015/12/30 06:00
MHDA- 2016/05/06 06:00
CRDT- 2015/12/30 06:00
PHST- 2015/12/30 06:00 [entrez]
PHST- 2015/12/30 06:00 [pubmed]
PHST- 2016/05/06 06:00 [medline]
AID - aqv008 [pii]
AID - 10.1093/ajcp/aqv008 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2016 Jan;145(1):134-9. doi: 10.1093/ajcp/aqv008.