PMID- 2671462
OWN - NLM
STAT- MEDLINE
DCOM- 19890927
LR  - 20190725
IS  - 0085-2538 (Print)
IS  - 0085-2538 (Linking)
VI  - 35
IP  - 5
DP  - 1989 May
TI  - Influence of shaking on peritoneal transfer in rats.
PG  - 1145-50
AB  - To determine the role played by stagnant peritoneal fluid layers in the diffusion 
      of solutes between peritoneal cavity and blood, we measured peritoneal transfer 
      of urea, creatinine, [14C]-L-glucose and protein in anesthetized rats shaken at 
      varying rates on an orbital platform shaker. The diffusion transfer rates of the 
      low molecular weight solutes increased dramatically with shaking, with near 
      maximal values obtained at a shaking rate of 250 RPM. The permeability area 
      product (PA) for each of the low molecular weight solutes increased about 
      fourfold with rapid shaking while the PA of protein increased by only about 50%. 
      It seems likely while the PA of protein increased by only about 50%. It seems 
      likely that shaking increased PA primarily via reduction of the thickness of 
      stagnant peritoneal fluid layers, although increases in surface area or changes 
      in tissue permeability cannot be excluded with certainty. We conclude that 
      stagnant fluid layers probably are the rate limiting step in diffusive peritoneal 
      transfer of low molecular weight solutes in stationary rats.
FAU - Levitt, M D
AU  - Levitt MD
AD  - Research Service, Veterans Administration Medical Center, Minneapolis, Minnesota.
FAU - Kneip, J M
AU  - Kneip JM
FAU - Overdahl, M C
AU  - Overdahl MC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (Blood Glucose)
RN  - 0 (Carbon Radioisotopes)
RN  - AYI8EX34EU (Creatinine)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Carbon Radioisotopes
MH  - Creatinine/metabolism
MH  - Glucose/*metabolism
MH  - Isomerism
MH  - Male
MH  - Movement
MH  - Peritoneal Cavity/*physiology
MH  - Radioisotope Dilution Technique
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
EDAT- 1989/05/01 00:00
MHDA- 1989/05/01 00:01
CRDT- 1989/05/01 00:00
PHST- 1989/05/01 00:00 [pubmed]
PHST- 1989/05/01 00:01 [medline]
PHST- 1989/05/01 00:00 [entrez]
AID - S0085-2538(15)34540-3 [pii]
AID - 10.1038/ki.1989.103 [doi]
PST - ppublish
SO  - Kidney Int. 1989 May;35(5):1145-50. doi: 10.1038/ki.1989.103.