PMID- 26714905
OWN - NLM
STAT- MEDLINE
DCOM- 20160426
LR  - 20211203
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 35
IP  - 12
DP  - 2015 Dec
TI  - [Protective effects of Zhenwutang on cardiac function in mice with uremic 
      cardiomyopathy induced by subtotal nephrectomy].
PG  - 1725-8
AB  - OBJECTIVE: To investigate the protective effects of Zhenwutang (ZWT) on cardiac 
      function in mice with uremic cardiomyopathy (UCM). METHODS: Thirty C57BL/6 mice 
      were randomized into 3 equal groups, including a sham-operated group, subtotal 
      nephrectomy (UCM model) group and subtotal nephrectomy with ZWT treatment group. 
      The mice in the former two groups were treated with distilled water. The changes 
      in cardiac functions, myocardial structure and renal function of the mice were 
      evaluated with echocardiography, HE staining and biochemical assay, respectively. 
      Western blotting was used to detect the expression level of adenosine 
      monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin 
      (mTOR) in the heart tissues. RESULTS: Compared with the sham-operated group, the 
      mice in the model group showed significantly lowered body weight and increased 
      heart weight, heart index, left ventricular posterior wall thickness in diastole 
      (LVPWd) and in systole (LVPWs), blood urea nitrogen (BUN) and serum creatinine 
      (Scr) (P<0.05); Pathological examination revealed myocardial hypertrophy in the 
      model group with markedly decreased expression levels of p-AMPK and significantly 
      increased p-mTOR expression (P<0.05). ZWT treatment significantly decreased the 
      heart weight, heart index, LVPWd, and LVPWs and expression level of p-mTOR 
      (P<0.05), increased the expression level of p-AMPK (P<0.05), and obviously 
      ameliorated histological injury of the heart in mice with UCM. CONCLUSION: ZWT 
      can protect the cardiac function in mice with subtotal nephrectomy-induced UCM 
      possibly via the AMPK-mTOR signal pathway.
FAU - Chen, Qi
AU  - Chen Q
AD  - Department of Cardiology, Zhujiang Hospital, Southern Medical University, 
      Guangzhou 510280, China. E-mail: chenqi0907@126.com.
FAU - Li, Zhiliang
AU  - Li Z
FAU - Liu, Bei
AU  - Liu B
FAU - Fu, Qiang
AU  - Fu Q
FAU - Yan, Quanneng
AU  - Yan Q
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 0 (Drugs, Chinese Herbal)
RN  - AYI8EX34EU (Creatinine)
RN  - EC 2.7.1.1 (mTOR protein, mouse)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
SB  - IM
MH  - AMP-Activated Protein Kinases/metabolism
MH  - Animals
MH  - Blood Urea Nitrogen
MH  - Cardiomyopathies/*drug therapy
MH  - Creatinine/blood
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Heart/*physiopathology
MH  - Heart Ventricles
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Myocardium/*pathology
MH  - *Nephrectomy
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/metabolism
EDAT- 2015/12/31 06:00
MHDA- 2016/04/27 06:00
CRDT- 2015/12/31 06:00
PHST- 2015/12/31 06:00 [entrez]
PHST- 2015/12/31 06:00 [pubmed]
PHST- 2016/04/27 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2015 Dec;35(12):1725-8.