PMID- 26715184
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20181113
IS  - 1297-9716 (Electronic)
IS  - 0928-4249 (Print)
IS  - 0928-4249 (Linking)
VI  - 46
DP  - 2015 Dec 29
TI  - Intranasal inoculation of sows with highly pathogenic porcine reproductive and 
      respiratory syndrome virus at mid-gestation causes transplacental infection of 
      fetuses.
PG  - 142
LID - 10.1186/s13567-015-0283-z [doi]
LID - 142
AB  - Transplacental infection plays a critical role in the reproductive failure 
      induced by porcine reproductive and respiratory syndrome virus (PRRSV), yet 
      exposure of sows and gilts to classical PRRSV generally leads to reproductive 
      failure after 85 days of gestation. We report, for the first time, that the 
      susceptibility of fetuses to highly pathogenic PRRSV (HP-PRRSV) is similar at 60 
      days and 90 days of gestation. This difference from classical PRRSV may 
      contribute to its high pathogenicity. A field study of the HP-PRRSV vaccine in 
      pregnant sows at mid-gestation should be considered.
FAU - Wang, Tongtong
AU  - Wang T
AD  - Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of 
      Animal Biotechnology and Disease Control and Prevention, College of Veterinary 
      Medicine, Shandong Agricultural University, Taian City, Shandong, China. 
      wangtong.1021@163.com.
FAU - Wang, Xiaofei
AU  - Wang X
AD  - Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of 
      Animal Biotechnology and Disease Control and Prevention, College of Veterinary 
      Medicine, Shandong Agricultural University, Taian City, Shandong, China. 
      wxf19890908@126.com.
FAU - Li, Xin-An
AU  - Li XA
AD  - Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of 
      Animal Biotechnology and Disease Control and Prevention, College of Veterinary 
      Medicine, Shandong Agricultural University, Taian City, Shandong, China. 
      xinan.1987@163.com.
FAU - Nie, Li
AU  - Nie L
AD  - Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of 
      Animal Biotechnology and Disease Control and Prevention, College of Veterinary 
      Medicine, Shandong Agricultural University, Taian City, Shandong, China. 
      nieli1221@163.com.
FAU - Zhang, Minxia
AU  - Zhang M
AD  - Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of 
      Animal Biotechnology and Disease Control and Prevention, College of Veterinary 
      Medicine, Shandong Agricultural University, Taian City, Shandong, China. 
      474659627@qq.com.
FAU - Liu, Sidang
AU  - Liu S
AD  - Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of 
      Animal Biotechnology and Disease Control and Prevention, College of Veterinary 
      Medicine, Shandong Agricultural University, Taian City, Shandong, China. 
      liusid@sdau.edu.cn.
FAU - Zhao, Xiaomin
AU  - Zhao X
AD  - Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of 
      Animal Biotechnology and Disease Control and Prevention, College of Veterinary 
      Medicine, Shandong Agricultural University, Taian City, Shandong, China. 
      xmzhao66@sdau.edu.cn.
FAU - Shang, Yingli
AU  - Shang Y
AD  - Institute for Immunology and School of Medicine, Tsinghua University, Beijing, 
      China. yinglish@126.com.
FAU - Zhou, En-Min
AU  - Zhou EM
AD  - College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 
      China. zhouem@nwsuaf.edu.cn.
FAU - Hiscox, Julian A
AU  - Hiscox JA
AD  - Department of Infection Biology, Institute of Infection and Global Health, 
      University of Liverpool, Liverpool, UK. Julian.Hiscox@liverpool.ac.uk.
FAU - Xiao, Yihong
AU  - Xiao Y
AD  - Department of Basic Veterinary Medicine, Shandong Provincial Key Laboratory of 
      Animal Biotechnology and Disease Control and Prevention, College of Veterinary 
      Medicine, Shandong Agricultural University, Taian City, Shandong, China. 
      xiaoyihong01@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151229
PL  - England
TA  - Vet Res
JT  - Veterinary research
JID - 9309551
SB  - IM
MH  - Animals
MH  - Female
MH  - Fetus/virology
MH  - *Maternal-Fetal Exchange
MH  - Porcine Reproductive and Respiratory Syndrome/*transmission
MH  - Porcine respiratory and reproductive syndrome virus/genetics/*physiology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*veterinary/virology
MH  - Swine
PMC - PMC4699371
EDAT- 2015/12/31 06:00
MHDA- 2016/09/27 06:00
PMCR- 2015/12/29
CRDT- 2015/12/31 06:00
PHST- 2015/05/26 00:00 [received]
PHST- 2015/11/20 00:00 [accepted]
PHST- 2015/12/31 06:00 [entrez]
PHST- 2015/12/31 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
PHST- 2015/12/29 00:00 [pmc-release]
AID - 10.1186/s13567-015-0283-z [pii]
AID - 283 [pii]
AID - 10.1186/s13567-015-0283-z [doi]
PST - epublish
SO  - Vet Res. 2015 Dec 29;46:142. doi: 10.1186/s13567-015-0283-z.