PMID- 26715570
OWN - NLM
STAT- MEDLINE
DCOM- 20160518
LR  - 20160115
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 102
IP  - 3
DP  - 2016 Feb
TI  - Myocardial deformation parameters predict outcome in patients with repaired 
      tetralogy of Fallot.
PG  - 209-15
LID - 10.1136/heartjnl-2015-308569 [doi]
AB  - BACKGROUND: Parameters of myocardial deformation have been suggested to be 
      superior to conventional measures of ventricular function and to predict outcome 
      in repaired tetralogy of Fallot (ToF). We aimed to test the hypothesis that 
      parameters of myocardial deformation on cardiac MRI (CMR) relate to symptoms and 
      provide prognostic information in patients with repaired ToF. METHODS AND 
      RESULTS: We included 372 patients with ToF (median age 16 years; 55% male), 
      recruited within a nationwide, prospective study. Longitudinal (LS), 
      circumferential (CS) and radial global strain (RS) were analysed by CMR-based 
      feature tracking (FT). A combined endpoint of death, successful resuscitation or 
      documented ventricular tachycardia was employed. Parameters of global strain were 
      associated with New York Heart Association (NYHA) class and symptomatic 
      deterioration. During a median follow-up of 7.4 years, 20 events occurred. Left 
      ventricular (LV) CS and right ventricular (RV) LS emerged as predictors of 
      outcome, independent of QRS duration, LV/RV ejection fraction and volumes, NYHA 
      class and peak oxygen uptake. In combination, these parameters also identified a 
      subgroup of patients at significantly increased risk of adverse of outcomes (HR 
      3.3, p=0.002). Furthermore, LV LS, RS, CS and RV LS were related to the risk of 
      death and nearly missed death (p<0.05 for all). CONCLUSIONS: FT-CMR provides 
      myocardial deformation parameters, easily derived from standard CMR studies. They 
      relate to symptoms and clinical deterioration in patients with ToF. More 
      importantly, they predict adverse outcome independent of established risk 
      markers, and should be considered as a useful adjunct to established outcome 
      predictors, especially in younger patients with ToF. CLINICAL TRIAL REGISTRATION 
      NUMBER: http://www.clinicaltrials.gov: NCT00266188; Results.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://www.bmj.com/company/products-services/rights-and-licensing/
FAU - Orwat, Stefan
AU  - Orwat S
AD  - Division of Adult Congenital and Valvular Heart Disease, Department of 
      Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.
FAU - Diller, Gerhard-Paul
AU  - Diller GP
AD  - Division of Adult Congenital and Valvular Heart Disease, Department of 
      Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.
FAU - Kempny, Aleksander
AU  - Kempny A
AD  - Division of Adult Congenital and Valvular Heart Disease, Department of 
      Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.
FAU - Radke, Robert
AU  - Radke R
AD  - Division of Adult Congenital and Valvular Heart Disease, Department of 
      Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.
FAU - Peters, Brigitte
AU  - Peters B
AD  - Institute for Biometry and Medical Informatics, University of Magdeburg, 
      Magdeburg, Germany.
FAU - Kuhne, Titus
AU  - Kuhne T
AD  - Department of Congenital Heart Disease/Pediatric Cardiology, German Heart Center 
      Berlin, Germany.
FAU - Boethig, Dietmar
AU  - Boethig D
AD  - Department of Pediatric Cardiology and Pediatric Intensive Care, Hannover Medical 
      School, Hannover, Germany.
FAU - Gutberlet, Matthias
AU  - Gutberlet M
AD  - Department of Diagnostic and Interventional Radiology, Heart Center, University 
      of Leipzig, Leipzig, Germany.
FAU - Dubowy, Karl-Otto
AU  - Dubowy KO
AD  - Department of Paediatric Cardiology, Heartcenter of North Rhine-Westphalia, 
      University of Bochum, Bad Oeynhausen, Germany.
FAU - Beerbaum, Philipp
AU  - Beerbaum P
AD  - Department of Pediatric Cardiology and Pediatric Intensive Care, Hannover Medical 
      School, Hannover, Germany.
FAU - Sarikouch, Samir
AU  - Sarikouch S
AD  - Department of Heart-, Thoracic-, Transplantation- and Vascular Surgery, Hannover 
      Medical School, Germany.
FAU - Baumgartner, Helmut
AU  - Baumgartner H
AD  - Division of Adult Congenital and Valvular Heart Disease, Department of 
      Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.
CN  - German Competence Network for Congenital Heart Defects Investigators
LA  - eng
SI  - ClinicalTrials.gov/NCT00266188
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151229
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
MH  - Adolescent
MH  - Cardiopulmonary Resuscitation
MH  - Child
MH  - Female
MH  - Heart/physiopathology
MH  - Heart Arrest/epidemiology/therapy
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Myocardium/*pathology
MH  - Prognosis
MH  - Prospective Studies
MH  - Tachycardia, Ventricular/epidemiology
MH  - Tetralogy of Fallot/mortality/physiopathology/*surgery
MH  - Ventricular Dysfunction, Left/*physiopathology
MH  - Ventricular Dysfunction, Right/*physiopathology
MH  - Young Adult
EDAT- 2015/12/31 06:00
MHDA- 2016/05/19 06:00
CRDT- 2015/12/31 06:00
PHST- 2015/09/05 00:00 [received]
PHST- 2015/11/19 00:00 [accepted]
PHST- 2015/12/31 06:00 [entrez]
PHST- 2015/12/31 06:00 [pubmed]
PHST- 2016/05/19 06:00 [medline]
AID - heartjnl-2015-308569 [pii]
AID - 10.1136/heartjnl-2015-308569 [doi]
PST - ppublish
SO  - Heart. 2016 Feb;102(3):209-15. doi: 10.1136/heartjnl-2015-308569. Epub 2015 Dec 
      29.