PMID- 2671601
OWN - NLM
STAT- MEDLINE
DCOM- 19891012
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 38
IP  - 9
DP  - 1989 Sep
TI  - Comparison of intraperitoneal and subcutaneous insulin administration on lipids, 
      apolipoproteins, fuel metabolites, and hormones in type I diabetes mellitus.
PG  - 908-12
AB  - The relative biologic efficacy of intraperitoneal (IP) insulin administration 
      over peripheral routes of insulin infusion for artificial delivery devices is 
      still poorly documented. Thus, the effects of IP insulin administration have been 
      compared with the effects of subcutaneous (SC) insulin administration upon 
      circulating fuel metabolites, hormones and lipoproteins. In a longitudinal study, 
      seven type I diabetic patients, aged 33 +/- 3 years, duration 16 +/- 4 years, 
      were studied. SC intensive insulin therapy was used for 3 months, then insulin 
      was infused IP via an implantable pump for 6 months with a similar good blood 
      glucose control. Lipids including high density lipoprotein (HDL) cholesterol and 
      low density lipoprotein (LDL) cholesterol, apolipoproteins A-I, A-II, and B were 
      measured every 3 months. Although all values remained in the normal range, 
      significant changes occurred in plasma triglycerides (63 +/- 9 SC v 88 +/- 12 
      mg/dL IP, P less than .05) and HDL-cholesterol (57 +/- 4 SC v 42 +/- 4 mg/dL IP, 
      P less than .05) without concomitant changes in apolipoprotein levels. In another 
      cross-sectional study, six of the patients consumed a standardized 400 kcal 
      breakfast after 0.15 U/kg insulin. Eight SC insulin infused age-, glucose 
      control- and weight-matched diabetic patients also underwent the same test using 
      SC insulin. Six normal subjects consumed the same breakfast and served as 
      controls. Plasma glucose, B-hydroxybutyrate, lactate, alanine, free fatty acids, 
      free insulin and glucagon were measured for five hours after the meal. All 
      measured parameters were comparable in both groups except free insulin and 
      lactate.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Selam, J L
AU  - Selam JL
AD  - Department of Medicine, University of California, Irvine.
FAU - Kashyap, M
AU  - Kashyap M
FAU - Alberti, K G
AU  - Alberti KG
FAU - Lozano, J
AU  - Lozano J
FAU - Hanna, M
AU  - Hanna M
FAU - Turner, D
AU  - Turner D
FAU - Jeandidier, N
AU  - Jeandidier N
FAU - Chan, E
AU  - Chan E
FAU - Charles, M A
AU  - Charles MA
LA  - eng
GR  - FD-R-000197-02/FD/FDA HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Apolipoproteins)
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Hormones)
RN  - 0 (Hydroxybutyrates)
RN  - 0 (Insulin)
RN  - 0 (Lactates)
RN  - 9007-92-5 (Glucagon)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Adult
MH  - Alanine/blood
MH  - Apolipoproteins/*metabolism
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Type 1/*metabolism
MH  - Drug Administration Routes
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Glucagon/metabolism
MH  - Hormones/*metabolism
MH  - Humans
MH  - Hydroxybutyrates/blood
MH  - Insulin/*administration & dosage/blood
MH  - Lactates/blood
MH  - *Lipid Metabolism
MH  - Male
EDAT- 1989/09/01 00:00
MHDA- 1989/09/01 00:01
CRDT- 1989/09/01 00:00
PHST- 1989/09/01 00:00 [pubmed]
PHST- 1989/09/01 00:01 [medline]
PHST- 1989/09/01 00:00 [entrez]
AID - 0026-0495(89)90240-0 [pii]
AID - 10.1016/0026-0495(89)90240-0 [doi]
PST - ppublish
SO  - Metabolism. 1989 Sep;38(9):908-12. doi: 10.1016/0026-0495(89)90240-0.