PMID- 26716499
OWN - NLM
STAT- MEDLINE
DCOM- 20161024
LR  - 20161230
IS  - 1098-9064 (Electronic)
IS  - 0094-6176 (Linking)
VI  - 42
IP  - 1
DP  - 2016 Feb
TI  - Allergy and Venous Thromboembolism: A Casual or Causative Association.
PG  - 63-8
LID - 10.1055/s-0035-1568876 [doi]
AB  - Allergic diseases are very frequent conditions worldwide. The pathogenesis of 
      allergic reactions and venous thromboembolism (VTE) shares several risk factors 
      and predisposing conditions. In particular, the concentration of immunoglobulin E 
      (IgE) is considerably increased in patients with allergic diseases, and this 
      immunoglobulin exert many prothrombotic and antifibrinolytic activities, 
      especially through interaction with mast cells. Therefore, this narrative review 
      is aimed to provide an overview of the current scientific evidence supporting a 
      potential relationship between allergy and the risk of VTE. Although no 
      prospective studies have been published so far, the evidence provided by six 
      large cross-sectional studies and several case reports support the existence of 
      an unquestionable epidemiological association between different allergic diseases 
      (especially atopy, asthma, and celiac disease) and venous thrombosis. Two 
      additional investigations reported that the concentration of IgE might predict 
      the onset of severe complications of pulmonary embolism such as pulmonary 
      infarction and pleural fluid accumulation. Therefore, the existence of a 
      convincing epidemiologic link between allergy and VTE paves the way to future 
      investigations aimed to establish whether the prevention or treatment of allergic 
      diseases might be regarded as an effective measure to lower the risk of VTE.
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Lippi, Giuseppe
AU  - Lippi G
AD  - Section of Clinical Biochemistry, University of Verona, Verona, Italy.
FAU - Favaloro, Emmanuel J
AU  - Favaloro EJ
AD  - Department of Haematology, Sydney Centres for Thrombosis and Haemostasis, 
      Institute of Clinical Pathology and Medical Research (ICPMR), Pathology West, NSW 
      Health Pathology, Westmead, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151230
PL  - United States
TA  - Semin Thromb Hemost
JT  - Seminars in thrombosis and hemostasis
JID - 0431155
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - *Hypersensitivity/blood/complications/epidemiology
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Mast Cells/*metabolism
MH  - *Pulmonary Infarction/blood/epidemiology/etiology
MH  - *Venous Thromboembolism/blood/epidemiology/etiology
EDAT- 2015/12/31 06:00
MHDA- 2016/10/25 06:00
CRDT- 2015/12/31 06:00
PHST- 2015/12/31 06:00 [entrez]
PHST- 2015/12/31 06:00 [pubmed]
PHST- 2016/10/25 06:00 [medline]
AID - 10.1055/s-0035-1568876 [doi]
PST - ppublish
SO  - Semin Thromb Hemost. 2016 Feb;42(1):63-8. doi: 10.1055/s-0035-1568876. Epub 2015 
      Dec 30.