PMID- 26717491
OWN - NLM
STAT- MEDLINE
DCOM- 20171013
LR  - 20180424
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 41
IP  - 8
DP  - 2016 Aug
TI  - Association of ICAM-1 and HMGA1 Gene Variants with Retinopathy in Type 2 Diabetes 
      Mellitus Among Chinese Individuals.
PG  - 1118-1122
AB  - PURPOSE: To evaluate the association of intercellular cell-adhesion molecule 1 
      (ICAM-1) and high-mobility group A1 (HMGA1) gene variants with diabetic 
      retinopathy (DR) in a Chinese type 2 diabetes mellitus (T2DM) cohort. METHODS: A 
      total of 792 patients with T2DM were enrolled and categorized into two groups: 
      (1) the DR group consisted of 448 patients, which was further subclassified into 
      the proliferative DR (PDR) group with 220 patients and the nonproliferative DR 
      (NPDR) group with 228 patients; (2) the diabetes without retinopathy (DNR) group 
      comprised 344 patients who had no signs of DR. The single-nucleotide polymorphism 
      (SNP) rs5498 in ICAM-1 gene and IVS5-13insC variant in HMGA1 gene were genotyped. 
      RESULTS: No evident association was found in the allele frequencies between SNP 
      rs5498 in ICAM-1 gene and DR patients; the combined p values for the additive, 
      dominant, and recessive models in genotype were greater than 0.05. No significant 
      association was identified between the IVS5-13insC variant in HMGA1 gene and DR 
      individuals. CONCLUSIONS: Our results revealed that SNP rs5498 in ICAM-1 gene and 
      IVS5-13insC variant in HMGA1 gene were not associated with the susceptibility of 
      DR in the Chinese T2DM cohort.
FAU - Lv, Zhiping
AU  - Lv Z
AD  - a Department of Ophthalmology , Qilu Hospital of Shandong University , Jinan , 
      China.
FAU - Li, Ying
AU  - Li Y
AD  - a Department of Ophthalmology , Qilu Hospital of Shandong University , Jinan , 
      China.
FAU - Wu, Yongzhong
AU  - Wu Y
AD  - b State Key Lab of Crystal Materials, Shandong University , Jinan , China.
FAU - Qu, Yi
AU  - Qu Y
AD  - a Department of Ophthalmology , Qilu Hospital of Shandong University , Jinan , 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151230
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 124544-67-8 (HMGA1a Protein)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/complications/*genetics/metabolism
MH  - Diabetic Retinopathy/epidemiology/etiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HMGA1a Protein/*genetics/metabolism
MH  - Humans
MH  - Incidence
MH  - Intercellular Adhesion Molecule-1/*genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Retrospective Studies
OTO - NOTNLM
OT  - High-mobility group A1
OT  - intercellular cell-adhesion molecule 1
OT  - retinopathy
OT  - type 2 diabetes mellitus
EDAT- 2015/12/31 06:00
MHDA- 2017/10/14 06:00
CRDT- 2015/12/31 06:00
PHST- 2015/12/31 06:00 [pubmed]
PHST- 2017/10/14 06:00 [medline]
PHST- 2015/12/31 06:00 [entrez]
AID - 10.3109/02713683.2015.1094093 [doi]
PST - ppublish
SO  - Curr Eye Res. 2016 Aug;41(8):1118-1122. doi: 10.3109/02713683.2015.1094093. Epub 
      2015 Dec 30.