PMID- 26717865
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20180105
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 44
IP  - 1
DP  - 2016 Jul
TI  - Signal decay mapping of myocardial edema using dual-contrast fast spin-echo MRI.
PG  - 186-93
LID - 10.1002/jmri.25142 [doi]
AB  - PURPOSE: To introduce a dual-contrast fast spin-echo (dcFSE) sequence for signal 
      decay mapping of myocardial edema. MATERIALS AND METHODS: After consultation with 
      the Institutional Review Board, 22 acute myocardial infarction (MI) patients were 
      examined with magnetic resonance imaging (MRI) at 1.5T 2 days after 
      revascularization. Edema was evaluated in 16 myocardial segments with an 
      exponential fit for signal decay time (SDT) in dcFSE mapping and T2 signal 
      intensity ratio for single-contrast FSE. Myocardial viability was evaluated in 
      late gadolinium enhancement (LGE). A control group of 10 volunteers was examined 
      for edema imaging. SDT was compared in segment groups: 1) with LGE in MI, 2) 
      penumbra, 3) remote from LGE, 4) controls. Groups 1/3 and 3/4 were tested on 
      difference. Three phantoms providing similar T2 but different T1 relaxation times 
      (low, intermediate, high) were examined with dcFSE and multicontrast spin echo 
      sequence as a reference. RESULTS: The SDT/T2 ratio for segment groups was 1) 
      82msec/1.7 in segments with LGE; 2) 65msec/1.6 for penumbra, 3) 62msec/1.7 for 
      remote segments, and 4) 50msec/1.6 in controls. In dcFSE group 1/3 (P < 0.0001) 
      and in group 3/4 (P = 0.0002) SDT was significantly different. In single-contrast 
      FSE the T2 ratio was not significantly different for both tests: 1/3 P = 0.1889; 
      3/4 P = 0.8879. T2 -overestimation of dcFSE was 23% in low, 29% in intermediate, 
      and 35% in highly T1 contaminated phantoms. CONCLUSION: dcFSE signal decay edema 
      mapping is feasible in volunteers and patients. DcFSE SDT is superior to T2 ratio 
      for detection of high-grade and diffuse myocardial edema. J. Magn. Reson. Imaging 
      2016;44:186-193.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Krumm, Patrick
AU  - Krumm P
AUID- ORCID: 0000-0003-1705-8439
AD  - Department of Diagnostic and Interventional Radiology, Eberhard Karls University, 
      Tubingen, Germany.
FAU - Martirosian, Petros
AU  - Martirosian P
AD  - Department of Diagnostic and Interventional Radiology, Section on Experimental 
      Radiology, Eberhard Karls University, Tubingen, Germany.
FAU - Rath, Dominik
AU  - Rath D
AD  - Department of Cardiology and Cardiovascular Medicine, Eberhard Karls University, 
      Tubingen, Germany.
FAU - Zitzelsberger, Tanja
AU  - Zitzelsberger T
AD  - Department of Diagnostic and Interventional Radiology, Eberhard Karls University, 
      Tubingen, Germany.
FAU - Ruff, Christer Andreas
AU  - Ruff CA
AD  - Department of Diagnostic and Interventional Radiology, Eberhard Karls University, 
      Tubingen, Germany.
FAU - Klumpp, Bernhard Daniel
AU  - Klumpp BD
AD  - Department of Diagnostic and Interventional Radiology, Eberhard Karls University, 
      Tubingen, Germany.
FAU - Nikolaou, Konstantin
AU  - Nikolaou K
AD  - Department of Diagnostic and Interventional Radiology, Eberhard Karls University, 
      Tubingen, Germany.
FAU - Gawaz, Meinrad
AU  - Gawaz M
AD  - Department of Cardiology and Cardiovascular Medicine, Eberhard Karls University, 
      Tubingen, Germany.
FAU - Geisler, Tobias
AU  - Geisler T
AD  - Department of Cardiology and Cardiovascular Medicine, Eberhard Karls University, 
      Tubingen, Germany.
FAU - Schick, Fritz
AU  - Schick F
AD  - Department of Diagnostic and Interventional Radiology, Section on Experimental 
      Radiology, Eberhard Karls University, Tubingen, Germany.
FAU - Kramer, Ulrich
AU  - Kramer U
AD  - Department of Diagnostic and Interventional Radiology, Eberhard Karls University, 
      Tubingen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20151231
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - 0 (Spin Labels)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Algorithms
MH  - Cardiac Imaging Techniques/*methods
MH  - Contrast Media/administration & dosage
MH  - Edema, Cardiac/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Spin Labels
OTO - NOTNLM
OT  - FSE
OT  - T2 mapping
OT  - cardiac MRI
OT  - edema
OT  - fast-spin-echo
EDAT- 2016/01/01 06:00
MHDA- 2018/01/03 06:00
CRDT- 2016/01/01 06:00
PHST- 2015/10/01 00:00 [received]
PHST- 2015/12/10 00:00 [accepted]
PHST- 2016/01/01 06:00 [entrez]
PHST- 2016/01/01 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
AID - 10.1002/jmri.25142 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2016 Jul;44(1):186-93. doi: 10.1002/jmri.25142. Epub 2015 
      Dec 31.