PMID- 26717912
OWN - NLM
STAT- MEDLINE
DCOM- 20170131
LR  - 20181113
IS  - 1432-1971 (Electronic)
IS  - 0172-0643 (Linking)
VI  - 37
IP  - 4
DP  - 2016 Apr
TI  - Feature Tracking-Derived Peak Systolic Strain Compared to Late Gadolinium 
      Enhancement in Troponin-Positive Myocarditis: A Case-Control Study.
PG  - 696-703
LID - 10.1007/s00246-015-1333-z [doi]
AB  - Cardiac magnetic resonance (CMR) assesses myocardial involvement in myocarditis 
      (MYO). Current techniques are qualitative, subjective, and prone to 
      interpretation error. Feature tracking (FT) analyzes myocardial strain using CMR 
      and has not been examined in MYO. We hypothesize that regional left ventricular 
      (LV) strain is abnormal in MYO. Regional strain by FT was compared to late 
      gadolinium enhancement (LGE) and troponin leak as measures of myocardial 
      involvement. This single-center, retrospective CMR study reviewed patients with 
      clinical MYO and structurally normal hearts who underwent CMR at our institution. 
      Young adults with normal cardiac anatomy, function, and absent LGE served as 
      controls. MYO patients with documented troponin leak and normal global ejection 
      fraction (EF > 50 %) were included in comparison. FT determined regional 
      myocardial peak systolic strain (pkS) in longitudinal and circumferential 
      distributions. T tests compared strain values between cases and controls. 
      Receiver operating characteristic curves determined pkS values with highest 
      sensitivity and specificity for concurrent troponin leak and LGE. FT was 
      performed on 57 patients: 37 MYO and 20 controls. Twenty-eight cases with normal 
      EF, and 20 control patients were included in final analysis. Nearly all cases 
      with normal function demonstrated abnormal regional pkS (27/28, 96 %). Cases had 
      significantly diminished pkS when compared to controls in all regions except the 
      longitudinal 2C distribution. FT-derived longitudinal and circumferential pkS is 
      sensitive and specific in identifying myocardial involvement, namely the presence 
      of troponin leak and LGE. FT may be a useful adjunctive, objective measure of 
      myocardial involvement in patients with MYO and normal LV function.
FAU - Weigand, Justin
AU  - Weigand J
AD  - Division of Pediatric Cardiology, Children's Hospital of San Antonio/Baylor 
      College of Medicine, 315 N. San Saba Street Suite 1135, San Antonio, TX, 78207, 
      USA. justin.weigand@bcm.edu.
FAU - Nielsen, James C
AU  - Nielsen JC
AD  - Department of Radiology and Pediatric Cardiology, Stony Brook Children's 
      Hospital, 100 Nicolls Road, Stony Brook, NY, 11794, USA.
FAU - Sengupta, Partho P
AU  - Sengupta PP
AD  - Department of Cardiology, Mount Sinai School of Medicine, One Gustave L. Levy 
      Place, Box 1030, New York, NY, 10029-6574, USA.
FAU - Sanz, Javier
AU  - Sanz J
AD  - Department of Cardiology, Mount Sinai School of Medicine, One Gustave L. Levy 
      Place, Box 1030, New York, NY, 10029-6574, USA.
FAU - Srivastava, Shubhika
AU  - Srivastava S
AD  - Division of Pediatric Cardiology, Mount Sinai School of Medicine, One Gustave L. 
      Levy Place, Box 1201, New York, NY, 10029, USA.
FAU - Uppu, Santosh
AU  - Uppu S
AD  - Division of Pediatric Cardiology, Mount Sinai School of Medicine, One Gustave L. 
      Levy Place, Box 1201, New York, NY, 10029, USA.
LA  - eng
PT  - Journal Article
DEP - 20151231
PL  - United States
TA  - Pediatr Cardiol
JT  - Pediatric cardiology
JID - 8003849
RN  - 0 (Contrast Media)
RN  - 0 (Troponin)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Contrast Media/chemistry
MH  - Echocardiography
MH  - Female
MH  - Gadolinium DTPA/chemistry
MH  - Heart Ventricles/*physiopathology
MH  - Humans
MH  - Logistic Models
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Myocarditis/*diagnostic imaging
MH  - Myocardium/*pathology
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Systole
MH  - Troponin/*blood
MH  - *Ventricular Function, Left
MH  - Young Adult
OTO - NOTNLM
OT  - Cardiovascular magnetic resonance imaging
OT  - Feature tracking
OT  - Myocardial delayed enhancement
OT  - Myocardial strain
OT  - Myocarditis
EDAT- 2016/01/01 06:00
MHDA- 2017/02/01 06:00
CRDT- 2016/01/01 06:00
PHST- 2015/10/11 00:00 [received]
PHST- 2015/12/15 00:00 [accepted]
PHST- 2016/01/01 06:00 [entrez]
PHST- 2016/01/01 06:00 [pubmed]
PHST- 2017/02/01 06:00 [medline]
AID - 10.1007/s00246-015-1333-z [pii]
AID - 10.1007/s00246-015-1333-z [doi]
PST - ppublish
SO  - Pediatr Cardiol. 2016 Apr;37(4):696-703. doi: 10.1007/s00246-015-1333-z. Epub 
      2015 Dec 31.