PMID- 26719807
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151231
LR  - 20210112
IS  - 2053-3624 (Print)
IS  - 2053-3624 (Electronic)
IS  - 2053-3624 (Linking)
VI  - 2
IP  - 1
DP  - 2015
TI  - Optical coherence tomography versus intravascular ultrasound to evaluate stent 
      implantation in patients with calcific coronary artery disease.
PG  - e000225
LID - 10.1136/openhrt-2014-000225 [doi]
LID - e000225
AB  - AIMS: Stent underexpansion and malapposition are associated with adverse outcomes 
      following percutaneous coronary intervention, but detection and treatment can be 
      challenging in the presence of extensive coronary artery calcification. Frequency 
      domain optical coherence tomography (FD-OCT) is a novel intravascular imaging 
      technique with greater spatial resolution than intravascular ultrasound (IVUS) 
      but its role in the presence of extensive coronary calcification remains unclear. 
      We sought to determine the utility of FD-OCT compared to IVUS imaging to guide 
      percutaneous coronary intervention in patients with severe calcific coronary 
      artery disease. METHODS: 18 matched IVUS and FD-OCT examinations were evaluated 
      following coronary stent implantation in 12 patients (10 male; mean age 
      70+/-7 years) undergoing rotational atherectomy for symptomatic calcific coronary 
      artery disease. RESULTS: In-stent luminal areas were smaller (minimum in-stent 
      area 6.77+/-2.18 vs 7.19+/-2.62 mm(2), p<0.05), while reference lumen dimensions were 
      similar with FD-OCT compared with IVUS. Stent malapposition was detected in all 
      patients by FD-OCT and in 10 patients by IVUS. The extent of stent malapposition 
      detected was greater (20% vs 6%, p<0.001) with FD-OCT compared to IVUS. 
      Postdilation increased the in-stent luminal area (minimum in-stent area: 
      8.15+/-1.90 vs 7.30+/-1.62 mm(2), p<0.05) and reduced the extent of stent 
      malapposition (19% vs 34%, p<0.005) when assessed by FD-OCT, but not IVUS. 
      CONCLUSIONS: Acute stent malapposition occurs frequently in patients with 
      calcific coronary disease undergoing rotational atherectomy and stent 
      implantation. In the presence of extensive coronary artery calcification, FD-OCT 
      affords enhanced stent visualisation and detection of malapposition, facilitating 
      improved postdilation stent apposition and minimal luminal areas. TRIAL 
      REGISTRATION NUMBER: NCT02065102.
FAU - Gudmundsdottir, Ingibjorg
AU  - Gudmundsdottir I
AD  - Royal Infirmary of Edinburgh , Edinburgh , UK.
FAU - Adamson, Philip
AU  - Adamson P
AD  - Royal Infirmary of Edinburgh , Edinburgh , UK.
FAU - Gray, Calum
AU  - Gray C
AD  - University of Edinburgh , Edinburgh , UK.
FAU - Spratt, James C
AU  - Spratt JC
AD  - Forth Valley Royal Hospital , Larbert , UK.
FAU - Behan, Miles W
AU  - Behan MW
AD  - Royal Infirmary of Edinburgh , Edinburgh , UK.
FAU - Henriksen, Peter
AU  - Henriksen P
AD  - Royal Infirmary of Edinburgh , Edinburgh , UK.
FAU - Newby, David E
AU  - Newby DE
AD  - University of Edinburgh , Edinburgh , UK.
FAU - Mills, Nicholas
AU  - Mills N
AD  - University of Edinburgh , Edinburgh , UK.
FAU - Uren, Neal G
AU  - Uren NG
AD  - Royal Infirmary of Edinburgh , Edinburgh , UK.
FAU - Cruden, Nicholas L
AU  - Cruden NL
AD  - Royal Infirmary of Edinburgh , Edinburgh , UK.
LA  - eng
SI  - ClinicalTrials.gov/NCT02065102
GR  - 103782/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151222
PL  - England
TA  - Open Heart
JT  - Open heart
JID - 101631219
CIN - Open Heart. 2015 Dec 22;2(1):e000292. PMID: 26719809
PMC - PMC4692048
OTO - NOTNLM
OT  - INTERVENTIONAL CARDIOLOGY
EDAT- 2016/01/01 06:00
MHDA- 2016/01/01 06:01
PMCR- 2015/12/22
CRDT- 2016/01/01 06:00
PHST- 2014/12/01 00:00 [received]
PHST- 2015/04/01 00:00 [revised]
PHST- 2015/05/06 00:00 [accepted]
PHST- 2016/01/01 06:00 [entrez]
PHST- 2016/01/01 06:00 [pubmed]
PHST- 2016/01/01 06:01 [medline]
PHST- 2015/12/22 00:00 [pmc-release]
AID - openhrt-2014-000225 [pii]
AID - 10.1136/openhrt-2014-000225 [doi]
PST - epublish
SO  - Open Heart. 2015 Dec 22;2(1):e000225. doi: 10.1136/openhrt-2014-000225. 
      eCollection 2015.