PMID- 26720484
OWN - NLM
STAT- MEDLINE
DCOM- 20160428
LR  - 20220330
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 56
IP  - 13
DP  - 2015 Dec
TI  - Glaucoma Detection Ability of Macular Ganglion Cell-Inner Plexiform Layer 
      Thickness in Myopic Preperimetric Glaucoma.
PG  - 8306-13
LID - 10.1167/iovs.15-18141 [doi]
AB  - PURPOSE: We evaluated the glaucoma detection ability of macular ganglion 
      cell-inner plexiform layer (GCIPL) thickness measured by spectral-domain optical 
      coherence tomography (SD-OCT) and compared it to peripapillary retinal nerve 
      fiber layer (RNFL) thickness and optic nerve head (ONH) parameters in myopic 
      preperimetric glaucoma (PPG). METHODS: We analyzed 353 eyes, including 67 
      nonmyopic preperimetric glaucomatous eyes, 182 myopic healthy eyes, and 104 
      myopic preperimetric glaucomatous eyes. Myopic PPG detection abilities of the 
      respective parameters were assessed by calculating the area under receiver 
      operating characteristic (AUROC) curves. The myopic eyes were divided into two 
      groups (a nonhighly myopic and a highly myopic group). The diagnostic performance 
      was analyzed for each group independently, and differences between the two groups 
      also were evaluated. RESULTS: The best parameter for discrimination of myopic PPG 
      from myopic healthy eyes was inferotemporal macular GCIPL thickness. The AUROCs 
      of this parameter were 0.752, 0.747, and 0.737 in the total myopic, nonhighly 
      myopic, and highly myopic groups, respectively. These were significantly larger 
      than the AUROCs of the other parameters, including average RNFL thickness, 
      average GCIPL thickness, rim area, inferior RNFL thickness, and minimum GCIPL 
      thickness (P = 0.021, 0.012, 0.016, 0.036, and 0.013, respectively). The 
      inferotemporal macular GCIPL thickness showed no significant difference between 
      nonhighly myopic and highly myopic groups. CONCLUSIONS: The inferotemporal 
      macular GCIPL thickness was the best PPG-detection parameter for myopic eyes. 
      Inferotemporal macular GCIPL thickness evaluation can be considered to be a 
      useful means of diagnosing PPG in myopic eyes.
FAU - Seol, Bo Ram
AU  - Seol BR
FAU - Jeoung, Jin Wook
AU  - Jeoung JW
FAU - Park, Ki Ho
AU  - Park KH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma/complications/*diagnosis/physiopathology
MH  - Humans
MH  - *Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Myopia/complications/*diagnosis/physiopathology
MH  - Nerve Fibers/pathology
MH  - Optic Disk/*pathology
MH  - ROC Curve
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Fields
EDAT- 2016/01/01 06:00
MHDA- 2016/04/29 06:00
CRDT- 2016/01/01 06:00
PHST- 2016/01/01 06:00 [entrez]
PHST- 2016/01/01 06:00 [pubmed]
PHST- 2016/04/29 06:00 [medline]
AID - 2479674 [pii]
AID - 10.1167/iovs.15-18141 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8306-13. doi: 10.1167/iovs.15-18141.