PMID- 26720837
OWN - NLM
STAT- MEDLINE
DCOM- 20160627
LR  - 20220321
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 12
DP  - 2015
TI  - Vessel Wall Inflammation of Takayasu Arteritis Detected by Contrast-Enhanced 
      Magnetic Resonance Imaging: Association with Disease Distribution and Activity.
PG  - e0145855
LID - 10.1371/journal.pone.0145855 [doi]
LID - e0145855
AB  - AIMS: The assessment of the distribution and activity of vessel wall inflammation 
      is clinically important in patients with Takayasu arteritis. Magnetic resonance 
      imaging (MRI) is a useful tool, but the clinical utility of late gadolinium 
      enhancement (LGE) in Takayasu arteritis has yet to be determined. The aim of the 
      present study was to evaluate the utility of LGE in assessing vessel wall 
      inflammation and disease activity in Takayasu arteritis. METHODS AND RESULTS: We 
      enrolled 49 patients with Takayasu arteritis who had undergone 1.5 T MRI. 
      Patients were divided into Active (n = 19) and Inactive disease (n = 30) groups. 
      The distribution of vessel wall inflammation using angiography and LGE was 
      assessed by qualitative analysis. In 79% and 63% of patients in Active and 
      Inactive groups, respectively, greater distribution of vessel wall inflammation 
      was observed with LGE than with conventional angiography. MRI values of pre- and 
      post-contrast signal-to-noise ratios (SNR), SNR increment (post-SNR minus 
      pre-SNR), pre- and post-contrast contrast-to-noise ratios (CNR), and CNR 
      increment (post-CNR minus pre-CNR) were evaluated at arterial wall sites with the 
      highest signal intensity using quantitative analysis of post-contrast LGE images. 
      No statistically significant differences in MRI parameters were observed between 
      Active and Inactive groups. Contrast-enhanced MRI was unable to accurately detect 
      active disease. CONCLUSION: Contrast-enhanced MRI has utility in detecting the 
      distribution of vessel wall inflammation but has less utility in assessing 
      disease activity in Takayasu arteritis.
FAU - Kato, Yoko
AU  - Kato Y
AD  - Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 
      Tokyo, Japan.
AD  - Cardiovascular Imaging Clinic, Tokyo, Japan.
FAU - Terashima, Masahiro
AU  - Terashima M
AD  - Cardiovascular Imaging Clinic, Tokyo, Japan.
FAU - Ohigashi, Hirokazu
AU  - Ohigashi H
AD  - Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 
      Tokyo, Japan.
FAU - Tezuka, Daisuke
AU  - Tezuka D
AD  - Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 
      Tokyo, Japan.
FAU - Ashikaga, Takashi
AU  - Ashikaga T
AD  - Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 
      Tokyo, Japan.
FAU - Hirao, Kenzo
AU  - Hirao K
AD  - Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 
      Tokyo, Japan.
FAU - Isobe, Mitsuaki
AU  - Isobe M
AD  - Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 
      Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151231
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adult
MH  - Aorta/pathology
MH  - *Contrast Media
MH  - Female
MH  - Humans
MH  - *Image Enhancement
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Angiography/methods
MH  - *Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Retrospective Studies
MH  - Signal-To-Noise Ratio
MH  - Takayasu Arteritis/*diagnosis/pathology
MH  - Young Adult
PMC - PMC4700986
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2016/01/01 06:00
MHDA- 2016/06/28 06:00
PMCR- 2015/12/31
CRDT- 2016/01/01 06:00
PHST- 2015/08/30 00:00 [received]
PHST- 2015/12/09 00:00 [accepted]
PHST- 2016/01/01 06:00 [entrez]
PHST- 2016/01/01 06:00 [pubmed]
PHST- 2016/06/28 06:00 [medline]
PHST- 2015/12/31 00:00 [pmc-release]
AID - PONE-D-15-37336 [pii]
AID - 10.1371/journal.pone.0145855 [doi]
PST - epublish
SO  - PLoS One. 2015 Dec 31;10(12):e0145855. doi: 10.1371/journal.pone.0145855. 
      eCollection 2015.