PMID- 26721005
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20181202
IS  - 1025-9589 (Print)
IS  - 1025-9589 (Linking)
VI  - 27
IP  - 3
DP  - 2015 Jul-Sep
TI  - RELATIONSHIP OF SERUM RESISTIN WITH INSULIN RESISTANCE AND OBESITY.
PG  - 552-5
AB  - BACKGROUND: Adipokines have been implicated in the modulation of insulin 
      sensitivity and glucose tolerance and have thus gained importance in the study of 
      Type 2 diabetes mellitus (T2DM). Resistin, a unique signalling molecule, is being 
      proposed as a significant factor in the pathogenesis of obesity-related insulin 
      resistance. However, its relevance to human diabetes mellitus remains uncertain 
      and controversial. This study was therefore planned to compare and correlate the 
      potential role of resistin in obese patients with T2DM and obese non-diabetic 
      controls and also to evaluate the correlation between resistin and marker of 
      obesity and glycaemic parameters. METHODS: Fasting serum resistin, glucose and 
      insulin were measured in forty obese diabetics (mean+/-SD BMI 35+/-5 kg/m2) and forty 
      obese non-diabetics (mean+/-SD BMI 33+/-3 kg/m2). Insulin resistance was assessed 
      using the HOMA-IR formula derived from fasting insulin and glucose levels. 
      RESULTS: Serum resistin levels (38+/-8 ng/ml) were significantly higher in type 2 
      diabetic patients as compared with the controls. Fasting blood glucose (164+/-46 
      mg/dl), serum insulin (37+/-7 microU/ml) and insulin resistance (19+/-8), were 
      considerably higher among the studied diabetics than in the controls. Pearson's 
      correlation analysis revealed positive correlation between serum resistin and BMI 
      (p=0.001) and HOMA-IR (p=0.561) in diabetic subjects. Similarly, a correlation 
      also existed between serum resistin and BMI (p=0.016) and HOMA-IR (p=0.307) in 
      control obese subjects. However, it was highly significant in diabetics as 
      compared to non-diabetic controls. CONCLUSION: A significant BMI-dependent 
      association exists between resistin and insulin resistance in patients with T2DM. 
      It appears that resistin may play a role in the pathogenesis of obesity and 
      insulin resistance and that both of these may contribute to the development of 
      T2DM.
FAU - Zaidi, Syeda Ijlal Zehra
AU  - Zaidi SI
FAU - Shirwany, Tanvir Ali Khan
AU  - Shirwany TA
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Ayub Med Coll Abbottabad
JT  - Journal of Ayub Medical College, Abbottabad : JAMC
JID - 8910750
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (RETN protein, human)
RN  - 0 (Resistin)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Fasting/blood
MH  - Female
MH  - Humans
MH  - Insulin/*blood
MH  - Insulin Resistance/*physiology
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood/complications
MH  - Resistin/*blood
EDAT- 2016/01/02 06:00
MHDA- 2016/02/03 06:00
CRDT- 2016/01/02 06:00
PHST- 2016/01/02 06:00 [entrez]
PHST- 2016/01/02 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
PST - ppublish
SO  - J Ayub Med Coll Abbottabad. 2015 Jul-Sep;27(3):552-5.