PMID- 26722498
OWN - NLM
STAT- MEDLINE
DCOM- 20161006
LR  - 20181113
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 10
DP  - 2015
TI  - Hyperbaric oxygen treatment ameliorates lung injury in paraquat intoxicated rats.
PG  - 13034-42
AB  - Paraquat (PQ) is an agrochemical agent commonly used worldwide, which can cause 
      acute lung injury (ALI) and death. Hyperbaric oxygen treatment (HBOT) is a 
      therapeutic method, but the mechanisms of the protective effect of HBOT on ALI 
      remain elusive. The purpose of this study was to evaluate the effect of HBOT on 
      acute lung injury induced by PQ in rats. Wistar Albino rats (n=21) were separated 
      into three groups of seven animals each: control (C), PQ, and PQ + HBOT groups. 
      20 mg/kg PQ was administered intraperitoneally in PQ and PQ + HBOT groups to 
      induce experimental lung injury. Three days after PQ treatment, PQ + HBOT group 
      was administered 100% O2 at 2.0 ATA for 1 hour per day, for five consecutive 
      days. At the end of the study, lung tissue was obtained for determining total 
      oxidant status (TOS), total antioxidant status (TAS), oxidative stress index 
      (OSI) and histopathological determination. Tumor necrosis factor-alpha (TNF-alpha), 
      interleukin 6 (IL-6), basic fibroblast growth factor (bFGF), transforming growth 
      factor (TGF)-beta1 mRNA levels were assessed by quantitative reverse 
      transcription-polymerase chain reaction. In addition, the inducible nitric oxide 
      synthase (iNOS) level in the plasma was determined. Plasma iNOS, OSI, tissue 
      TNF-alpha, TGF-beta1 and bFGF mRNA levels, and histological injury scores in PQ + HBOT 
      group were significantly lower than PQ group. TAS level in PQ + HBOT group was 
      significantly higher than PQ group. The findings suggest that HBOT could 
      effectively ameliorate PQ-induced lung injury in rats.
FAU - Akcilar, Raziye
AU  - Akcilar R
AD  - Department of Physiology, Faculty of Medicine, University of Dumlupinar Kutahya, 
      Turkey.
FAU - Akcilar, Aydin
AU  - Akcilar A
AD  - Faculty of Medicine, University of Dumlupinar, Experimental Animal Research 
      Center Kutahya, Turkey.
FAU - Simsek, Hasan
AU  - Simsek H
AD  - Department of Physiology, Faculty of Medicine, University of Dumlupinar Kutahya, 
      Turkey.
FAU - Kocak, Fatma Emel
AU  - Kocak FE
AD  - Department of Biochemistry, Faculty of Medicine, University of Dumlupinar 
      Kutahya, Turkey.
FAU - Kocak, Cengiz
AU  - Kocak C
AD  - Department of Pathology, Faculty of Medicine, University of Dumlupinar Kutahya, 
      Turkey.
FAU - Yumun, Gunduz
AU  - Yumun G
AD  - Department of Cardiovascular Surgery, Faculty of Medicine, University of Namik 
      Kemal Tekirdag, Turkey.
FAU - Bayat, Zeynep
AU  - Bayat Z
AD  - Department of Biochemistry, Faculty of Arts and Sciences, University of 
      Dumlupinar Kutahya, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20151001
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Herbicides)
RN  - PLG39H7695 (Paraquat)
SB  - IM
MH  - Acute Lung Injury/*chemically induced/pathology/*therapy
MH  - Animals
MH  - Disease Models, Animal
MH  - Herbicides/*toxicity
MH  - Hyperbaric Oxygenation/*methods
MH  - Male
MH  - Oxidative Stress/physiology
MH  - Paraquat/*toxicity
MH  - Rats
MH  - Rats, Wistar
MH  - Reverse Transcriptase Polymerase Chain Reaction
PMC - PMC4680443
OTO - NOTNLM
OT  - Paraquat
OT  - antioxidant
OT  - hyperbaric oxygen treatment
OT  - lung injury
OT  - oxidant
EDAT- 2016/01/02 06:00
MHDA- 2016/10/08 06:00
PMCR- 2015/10/01
CRDT- 2016/01/02 06:00
PHST- 2015/08/07 00:00 [received]
PHST- 2015/09/21 00:00 [accepted]
PHST- 2016/01/02 06:00 [entrez]
PHST- 2016/01/02 06:00 [pubmed]
PHST- 2016/10/08 06:00 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 Oct 1;8(10):13034-42. eCollection 2015.