PMID- 26722560
OWN - NLM
STAT- MEDLINE
DCOM- 20161011
LR  - 20181113
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 10
DP  - 2015
TI  - Levels of hepatocyte growth factor in serum correlate with quality of life in 
      hemodialysis patients.
PG  - 13477-82
AB  - PURPOSE: Patients with end stage renal failure (ESRD) report low quality of life 
      and inflammation may be one of the contributing factors. We studied if the 
      hemodialysis induced inflammation correlates with the patients quality of life. 
      METHODS: Study was performed in 76 (35 males and 41 females) ESRD patients 
      treated with hemodialysis. Effect of one dialysis session on blood concentration 
      of Vascular Endothelial Growth Factor (VEGF), Hepatocyte Growth Factor (HGF), 
      Interleukin 6 (IL6) and Monocyte Chemoattractant Protein-1 (MCP-1) was studied. 
      Results were correlated with answers given by patients to a short questionnaire 
      composed of questions from Kidney Disease Quality of Life Short Form (KDQoL-SF) 
      questionnaire. RESULTS: Hemodialysis induced increase of serum level of HGF 
      (+117%) and IL-6 (+17%). Declared by patients health status correlated with their 
      age, GFR, kt/V and hemodialysis induced change in serum IL6 and HGF level (R(2) = 
      0469, P < 0.001). Physical activity correlated with age, serum IL-6 and 
      hemodialysis induced change in serum HGF and VEGF (R(2) = 0.362, P < 0.001). 
      Presence of social/mental problems during previous 4 weeks correlated with age, 
      serum HGF and hemodialysis induced changes in serum HGF and VEGF levels (R(2) = 
      0.333, P < 0.001). Interference of the kidney disease with daily life activities 
      correlated with age, serum VEGF and hemodialysis induced change in serum HGF and 
      IL6 levels (R(2) = 0.422, P < 0.001). CONCLUSION: Inflammation correlates with 
      reduced quality of life in ESRD. Low hemodialysis-induced release of the 
      anti-inflammatory cytokine HGF correlates with impaired quality of life in that 
      group of patients.
FAU - Baum, Ewa
AU  - Baum E
AD  - Department of Pathophysiology, PUMS Poland ; Department of Philosophy of Medicine 
      and Bioethics, PUMS Poland.
FAU - Pawlaczyk, Krzysztof
AU  - Pawlaczyk K
AD  - Department of Pathophysiology, PUMS Poland ; Department of Nephrology, PUMS 
      Poland.
FAU - Mackowiak, Beata
AU  - Mackowiak B
AD  - Department of Pathophysiology, PUMS Poland.
FAU - Sosinska, Patrycja
AU  - Sosinska P
AD  - Department of Pathophysiology, PUMS Poland.
FAU - Matecka, Monika
AU  - Matecka M
AD  - Department of Pathophysiology, PUMS Poland.
FAU - Kolodziejczak, Barbara
AU  - Kolodziejczak B
AD  - Department of Pathophysiology, PUMS Poland.
FAU - Musielak, Michal
AU  - Musielak M
AD  - Department of Pathophysiology, PUMS Poland ; Department of Philosophy of Medicine 
      and Bioethics, PUMS Poland.
FAU - Breborowicz, Andrzej
AU  - Breborowicz A
AD  - Department of Pathophysiology, PUMS Poland ; Higher Vocational State School 
      Kalisz, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151001
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (HGF protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Hepatocyte Growth Factor/*blood
MH  - Humans
MH  - Inflammation/*blood/*etiology
MH  - Interleukin-6/blood
MH  - Kidney Failure, Chronic/blood/therapy
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - Renal Dialysis/*adverse effects
MH  - Surveys and Questionnaires
MH  - Vascular Endothelial Growth Factor A/blood
PMC - PMC4680505
OTO - NOTNLM
OT  - Uremia-hemodialysis
OT  - hepatocyte growth factor
OT  - inflammation
OT  - quality of life
EDAT- 2016/01/02 06:00
MHDA- 2016/10/12 06:00
PMCR- 2015/10/01
CRDT- 2016/01/02 06:00
PHST- 2015/08/06 00:00 [received]
PHST- 2015/09/25 00:00 [accepted]
PHST- 2016/01/02 06:00 [entrez]
PHST- 2016/01/02 06:00 [pubmed]
PHST- 2016/10/12 06:00 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 Oct 1;8(10):13477-82. eCollection 2015.