PMID- 26722860
OWN - NLM
STAT- MEDLINE
DCOM- 20180802
LR  - 20180802
IS  - 1933-0693 (Electronic)
IS  - 0022-3085 (Linking)
VI  - 125
IP  - 2
DP  - 2016 Aug
TI  - Different aspects of dysexecutive syndrome in patients with moyamoya disease and 
      its clinical subtypes.
PG  - 299-307
LID - 10.3171/2015.7.JNS142666 [doi]
AB  - OBJECTIVE Dysexecutive syndrome is common in patients with moyamoya disease 
      (MMD), a chronic cerebrovascular disease that is characterized by stenosis of the 
      bilateral internal carotid arteries and progressive collateral revascularization, 
      and MMD can be classified as ischemic or hemorrhagic according to the disease 
      presentation and history. In this study, the authors aimed to determine which 
      aspects of executive function are impaired in patients with MMD, in addition to 
      the specific dysexecutive functions present among its clinical subtypes and the 
      mechanisms underlying dysexecutive function in these patients. METHODS The 
      authors administered 5 typical executive function tests (the Stroop test, the 
      Hayling Sentence Completion Test [HSCT], the verbal fluency [VF] test, the N-back 
      test, and the Sustained Attention to Response Task [SART]) to 49 patients with 
      MMD and 47 IQ-, age-, education-, and social status-matched healthy controls. The 
      dysexecutive questionnaire (DEX) was also used to assess participants' subjective 
      feelings about their executive function. A total of 39 of the patients were 
      evaluated by CT perfusion (CTP) before the assessments were performed, and the 
      correlations among the performances of the patients on the above tests with the 
      parameters of cerebral blood volume, cerebral blood flow (CBF), mean transit time 
      (MTT), and time-to-peak (TTP) in the frontal lobes of these patients were also 
      analyzed. RESULTS Many aspects of executive function in the patients with MMD 
      were significantly poorer than those in the healthy controls, and the patients 
      performed particularly poorer on the VF test, HSCT, N-back test, and SART. The 
      patients with hemorrhagic MMD exhibited worse executive inhibition, executive 
      processing, and semantic inhibition compared with those with ischemic MMD, but 
      the latter group presented a worse working memory and poorer sustained attention. 
      There were no significant differences in the DEX scores between the patients with 
      MMD and healthy controls. The other findings were as follows: CBF was 
      significantly positively correlated with the number correct on part B of the HSCT 
      (r = 0.481, p = 0.01) and accuracy on the 0-back task of the N-back (r = 0.346, p 
      = 0.031); MTT was significantly positively correlated with accuracy on the 2-back 
      task of the N-back (r = 0.349, p = 0.034) and factor 5 of the DEX (r = 0.359, p = 
      0.032); and TTP was significantly positively correlated with the number correct 
      on part B of the HSCT (r = 0.402, p = 0.034) and the 1-back reaction time of the 
      N-back (r = 0.356, p = 0.026). CONCLUSIONS The patients with MMD exhibited 
      impairments in semantic inhibition, executive processing, working memory, and 
      sustained attention, but they were not aware of these deficits. Moreover, 
      differences in dysexecutive function existed between the different subtypes of 
      MMD. Hypoperfusion of the frontal lobe may be related to working memory and 
      semantic inhibition impairments in patients with MMD.
FAU - Fang, Lingling
AU  - Fang L
AD  - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; 
      China National Clinical Research Center for Neurological Diseases; Center of 
      Stroke, Beijing Institute for Brain Disorders; Beijing Key Laboratory of 
      Translational Medicine for Cerebrovascular Disease; and.
FAU - Huang, Jia
AU  - Huang J
AD  - Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of 
      Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 
      China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; 
      China National Clinical Research Center for Neurological Diseases; Center of 
      Stroke, Beijing Institute for Brain Disorders; Beijing Key Laboratory of 
      Translational Medicine for Cerebrovascular Disease; and.
FAU - Chan, Raymond C K
AU  - Chan RC
AD  - Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of 
      Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 
      China.
FAU - Wang, Rong
AU  - Wang R
AD  - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; 
      China National Clinical Research Center for Neurological Diseases; Center of 
      Stroke, Beijing Institute for Brain Disorders; Beijing Key Laboratory of 
      Translational Medicine for Cerebrovascular Disease; and.
FAU - Wan, Weiqing
AU  - Wan W
AD  - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; 
      China National Clinical Research Center for Neurological Diseases; Center of 
      Stroke, Beijing Institute for Brain Disorders; Beijing Key Laboratory of 
      Translational Medicine for Cerebrovascular Disease; and.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160101
PL  - United States
TA  - J Neurosurg
JT  - Journal of neurosurgery
JID - 0253357
SB  - IM
MH  - Adult
MH  - Affective Symptoms/diagnosis/*etiology
MH  - Cognition Disorders/diagnosis/*etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Disorders/diagnosis/*etiology
MH  - Moyamoya Disease/*classification/*complications
MH  - Neuropsychological Tests
MH  - Syndrome
OTO - NOTNLM
OT  - CBF = cerebral blood flow
OT  - CBV = cerebral blood volume
OT  - CTP = CT perfusion
OT  - DEX = dysexecutive questionnaire
OT  - HSCT = Hayling Sentence Completion Test
OT  - ICA = internal carotid artery
OT  - MMD = moyamoya disease
OT  - MTT = mean transit time
OT  - ROI = region of interest
OT  - RT = reaction time
OT  - SART = Sustained Attention to Response Task
OT  - TIA = transient ischemic attack
OT  - TTP = time-to-peak
OT  - VF = verbal fluency
OT  - dysexecutive function
OT  - moyamoya disease
OT  - presentation
OT  - vascular disorders
EDAT- 2016/01/02 06:00
MHDA- 2018/08/03 06:00
CRDT- 2016/01/02 06:00
PHST- 2016/01/02 06:00 [entrez]
PHST- 2016/01/02 06:00 [pubmed]
PHST- 2018/08/03 06:00 [medline]
AID - 10.3171/2015.7.JNS142666 [doi]
PST - ppublish
SO  - J Neurosurg. 2016 Aug;125(2):299-307. doi: 10.3171/2015.7.JNS142666. Epub 2016 
      Jan 1.