PMID- 26723902
OWN - NLM
STAT- MEDLINE
DCOM- 20170315
LR  - 20231213
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 77
IP  - 9
DP  - 2016 Sep
TI  - Relevance of HLA-G, HLA-E and IL-10 expression in lip carcinogenesis.
PG  - 785-90
LID - S0198-8859(15)00581-9 [pii]
LID - 10.1016/j.humimm.2015.12.001 [doi]
AB  - HLA-G, HLA-E and IL-10 are molecules which can provide tumor immunosuppression as 
      well as the capacity of evasion to the immune system host. This study set out to 
      evaluate HLA-G, HLA-E and IL-10 expression in lip squamous cell carcinoma (LSCC) 
      and in a potentially malignant disorder (actinic cheilitis - AC), correlating the 
      expression of these proteins with the degree of epithelial dysplasia. 
      Immunohistochemistry was undertaken to identify HLA-G, HLA-E and IL-10 in samples 
      from patients with LSCC (n=20), AC (n=30) and healthy lip mucosa (control) 
      (n=10). A semiquantitative scoring system was used for analysis. Differences 
      between the groups were evaluated using the Pearson Chi-Squared test. The 
      percentage of LSCC samples showing high immunoreactivity (IRS>2) for HLA-G, HLA-E 
      and IL-10 (neoplastic/epithelial cells) and HLA-E (stroma/connective tissue) was 
      significantly higher that of the control (P<0.05). A tendency for a progressive 
      increase in the proteins analyzed was observed from the control to AC and to 
      LSCC. The degree of dysplasia in the AC samples was not significantly associated 
      with the proteins evaluated (P>0.05). The high expression of HLA-G, HLA-E and 
      IL-10 in AC and LSCC reflects the capacity that these pathologies have for 
      evasion and progression.
CI  - Copyright (c) 2015. Published by Elsevier Inc.
FAU - Goncalves, Andreia Souza
AU  - Goncalves AS
AD  - Department of Stomatology (Oral Pathology), Dental School, Federal University of 
      Goias, Goiania, Brazil. Electronic address: andreia.sg.odonto@gmail.com.
FAU - Oliveira, Jessica Petini
AU  - Oliveira JP
AD  - Department of Stomatology (Oral Pathology), Dental School, Federal University of 
      Goias, Goiania, Brazil. Electronic address: jessicapetini@hotmail.com.
FAU - Oliveira, Carolina Ferrari Piloni
AU  - Oliveira CF
AD  - Department of Stomatology (Oral Pathology), Dental School, Federal University of 
      Goias, Goiania, Brazil. Electronic address: carolinaferraripo1@hotmail.com.
FAU - Silva, Tarcilia Aparecida
AU  - Silva TA
AD  - Department of Oral Surgery and Pathology, Dental School, Federal University of 
      Minas Gerais, Belo Horizonte, Brazil. Electronic address: 
      tarcilia@odonto.ufmg.br.
FAU - Mendonca, Elismauro Francisco
AU  - Mendonca EF
AD  - Department of Stomatology (Oral Pathology), Dental School, Federal University of 
      Goias, Goiania, Brazil. Electronic address: elismaur@odonto.ufg.br.
FAU - Wastowski, Isabela Jube
AU  - Wastowski IJ
AD  - Department of Biology, State University of Goias, Morrinhos, Goias, Brazil. 
      Electronic address: wastowski@gmail.com.
FAU - Batista, Aline Carvalho
AU  - Batista AC
AD  - Department of Stomatology (Oral Pathology), Dental School, Federal University of 
      Goias, Goiania, Brazil. Electronic address: ali.caba@uol.com.br.
LA  - eng
PT  - Journal Article
DEP - 20151223
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (IL10 protein, human)
RN  - 130068-27-8 (Interleukin-10)
RN  - Actinic cheilitis
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinogenesis
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Cheilitis/*metabolism/pathology
MH  - Female
MH  - HLA-G Antigens/immunology/*metabolism
MH  - Histocompatibility Antigens Class I/immunology/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Interleukin-10/immunology/*metabolism
MH  - Lip Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Mouth Mucosa/*pathology
MH  - Young Adult
MH  - HLA-E Antigens
OTO - NOTNLM
OT  - HLA-E
OT  - HLA-G
OT  - IL-10
OT  - Lip carcinogenesis
OT  - Potentially malignant disorder
EDAT- 2016/01/03 06:00
MHDA- 2017/03/16 06:00
CRDT- 2016/01/03 06:00
PHST- 2015/10/02 00:00 [received]
PHST- 2015/11/20 00:00 [revised]
PHST- 2015/12/01 00:00 [accepted]
PHST- 2016/01/03 06:00 [entrez]
PHST- 2016/01/03 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
AID - S0198-8859(15)00581-9 [pii]
AID - 10.1016/j.humimm.2015.12.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2016 Sep;77(9):785-90. doi: 10.1016/j.humimm.2015.12.001. Epub 2015 
      Dec 23.