PMID- 2672433
OWN - NLM
STAT- MEDLINE
DCOM- 19891003
LR  - 20190727
IS  - 0041-1132 (Print)
IS  - 0041-1132 (Linking)
VI  - 29
IP  - 7
DP  - 1989 Sep
TI  - Prevalence of antibodies to human immunodeficiency virus type 1 among blood 
      donors prior to screening. The Transfusion Safety Study/NHLBI Donor Repository.
PG  - 572-80
AB  - The Transfusion Safety Study (TSS) and the National Heart, Lung, and Blood 
      Institute (NHLBI) established a repository of approximately 200,000 sera from 
      blood donors in late 1984 and early 1985. Collections were made in the four 
      metropolitan areas with the highest prevalence of AIDS. Retrospective testing 
      showed an overall anti-HIV-1 prevalence of 16 cases per 10,000 donations. In this 
      study, the predictive value of a negative initial enzyme-linked immunoassay was 
      estimated from both quality control specimens and the rescreening of 13,461 sera 
      to be greater than 99.99 percent with respect to technical error. Among 
      anti-HIV-1-positive persons, there was a 1.3- to 1.5-fold excess of first-time 
      donors. The anti-HIV-1 prevalence among donors showed that infection was more 
      common among young men than suggested by national reporting of AIDS cases. 
      Anti-HIV-1 prevalence varied among the four metropolitan areas less than did 
      reported AIDS cases, but, by 1987, the differences in the latter had decreased. 
      Anti-HIV-1 prevalence in collection areas outside of the four major cities 
      differed much more widely than that among the cities themselves. The TSS/NHLBI 
      Donor Repository will remain available for the indefinite future for further 
      evaluation of screening procedures for HIV-1 and other viruses for which 
      transfusion is found to be an important route of transmission.
FAU - Kleinman, S H
AU  - Kleinman SH
AD  - American Red Cross Blood Services, Los Angeles, California.
FAU - Niland, J C
AU  - Niland JC
FAU - Azen, S P
AU  - Azen SP
FAU - Operskalski, E A
AU  - Operskalski EA
FAU - Barbosa, L H
AU  - Barbosa LH
FAU - Chernoff, A I
AU  - Chernoff AI
FAU - Edwards, V M
AU  - Edwards VM
FAU - Lenes, B A
AU  - Lenes BA
FAU - Marshall, G J
AU  - Marshall GJ
FAU - Nemo, G J
AU  - Nemo GJ
AU  - et al.
LA  - eng
GR  - N01-HB-4-7002/HB/NHLBI NIH HHS/United States
GR  - N01-HB-4-7003/HB/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (HIV Antibodies)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/epidemiology
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - *Blood Donors
MH  - Cross-Sectional Studies
MH  - Female
MH  - HIV Antibodies/*analysis
MH  - HIV Seropositivity/diagnosis/*epidemiology/transmission
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Middle Aged
MH  - National Institutes of Health (U.S.)
MH  - Quality Control
MH  - *Transfusion Reaction
MH  - United States
EDAT- 1989/09/01 00:00
MHDA- 1989/09/01 00:01
CRDT- 1989/09/01 00:00
PHST- 1989/09/01 00:00 [pubmed]
PHST- 1989/09/01 00:01 [medline]
PHST- 1989/09/01 00:00 [entrez]
AID - 10.1046/j.1537-2995.1989.29789369672.x [doi]
PST - ppublish
SO  - Transfusion. 1989 Sep;29(7):572-80. doi: 10.1046/j.1537-2995.1989.29789369672.x.