PMID- 26724366
OWN - NLM
STAT- MEDLINE
DCOM- 20161020
LR  - 20161230
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 454
DP  - 2016 Feb 15
TI  - Serum CXCL12 concentration in patients with severe traumatic brain injury are 
      associated with mortality.
PG  - 6-9
LID - S0009-8981(15)30102-9 [pii]
LID - 10.1016/j.cca.2015.12.033 [doi]
AB  - BACKGROUND: CXC chemokine ligand-12 (CXCL12) is released during brain injury. The 
      objective of this study was to investigate relationship between serum CXCL12 
      concentration, mortality and trauma severity in patients with traumatic brain 
      injury (TBI). METHODS: We determined serum CXCL12 concentration of 132 controls 
      and 132 patients with severe TBI. Trauma severity was assessed using Glasgow Coma 
      Scale (GCS) score. The end-point of the study was 30-day mortality. RESULTS: 
      Serum CXCL12 concentration were significantly higher in the patients than in the 
      controls (13.3+/-6.8 vs. 1.5+/-0.5 ng/ml, P<0.001). There was a negative correlation 
      between CXCL12 concentration and GCS scores (r=-0.588, P<0.001). The optimal 
      cutoff value of CXCL12 as a mortality indicator was estimated to be 15.4 ng/ml, 
      which yielded a sensitivity of 71.0% and a specificity of 72.2%, with the area 
      under curve at 0.808 [95% confidence (CI), 0.730-0.871]. Serum CXCL12 
      concentration>19.5 ng/ml were associated independently with 30-day mortality 
      (odds ratio, 6.951; 95% CI, 2.027-18.477; P<0.001) and 30-day overall survival 
      (hazard ratio, 4.398; 95% CI, 2.088-15.286; P<0.001). CONCLUSIONS: Increased 
      serum CXCL12 concentration is associated highly with trauma severity and 
      mortality following TBI.
CI  - Copyright (c) 2015. Published by Elsevier B.V.
FAU - Chen, Tie-Jiang
AU  - Chen TJ
AD  - Department of Emergency Surgery, Yiwu Central Hospital, 699 Jiangdong Road, Yiwu 
      322000, Zhejiang Province, China. Electronic address: hzhzzhoufeng@163.com.
FAU - Wu, Wu-Quan
AU  - Wu WQ
AD  - Department of Emergency Surgery, Yiwu Central Hospital, 699 Jiangdong Road, Yiwu 
      322000, Zhejiang Province, China.
FAU - Ying, Guang-Rong
AU  - Ying GR
AD  - Department of Emergency Surgery, Yiwu Central Hospital, 699 Jiangdong Road, Yiwu 
      322000, Zhejiang Province, China.
FAU - Fu, Qing-Yang
AU  - Fu QY
AD  - Department of Emergency Surgery, Yiwu Central Hospital, 699 Jiangdong Road, Yiwu 
      322000, Zhejiang Province, China.
FAU - Xiong, Kai
AU  - Xiong K
AD  - Department of Emergency Surgery, Yiwu Central Hospital, 699 Jiangdong Road, Yiwu 
      322000, Zhejiang Province, China.
LA  - eng
PT  - Journal Article
DEP - 20151224
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Brain Injuries/*blood/diagnosis/*mortality
MH  - Chemokine CXCL12/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Survival Analysis
MH  - *Trauma Severity Indices
MH  - Young Adult
OTO - NOTNLM
OT  - CXC chemokine ligand-12
OT  - Mortality
OT  - Severity
OT  - Traumatic brain injury
EDAT- 2016/01/03 06:00
MHDA- 2016/10/21 06:00
CRDT- 2016/01/03 06:00
PHST- 2015/12/05 00:00 [received]
PHST- 2015/12/22 00:00 [revised]
PHST- 2015/12/22 00:00 [accepted]
PHST- 2016/01/03 06:00 [entrez]
PHST- 2016/01/03 06:00 [pubmed]
PHST- 2016/10/21 06:00 [medline]
AID - S0009-8981(15)30102-9 [pii]
AID - 10.1016/j.cca.2015.12.033 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2016 Feb 15;454:6-9. doi: 10.1016/j.cca.2015.12.033. Epub 2015 
      Dec 24.