PMID- 26724974
OWN - NLM
STAT- MEDLINE
DCOM- 20171117
LR  - 20231111
IS  - 2212-4934 (Electronic)
IS  - 2212-4926 (Print)
IS  - 2212-4926 (Linking)
VI  - 61
DP  - 2016 May
TI  - Phosphoinositide signaling in somatosensory neurons.
PG  - 2-16
LID - S2212-4926(15)30032-4 [pii]
LID - 10.1016/j.jbior.2015.11.012 [doi]
AB  - Somatosensory neurons of the dorsal root ganglia (DRG) and trigeminal ganglia 
      (TG) are responsible for detecting thermal and tactile stimuli. They are also the 
      primary neurons mediating pain and itch. A large number of cell surface receptors 
      in these neurons couple to phospholipase C (PLC) enzymes leading to the 
      hydrolysis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and the 
      generation of downstream signaling molecules. These neurons also express many 
      different ion channels, several of which are regulated by phosphoinositides. This 
      review will summarize the knowledge on phosphoinositide signaling in DRG neurons, 
      with special focus on effects on sensory and other ion channels.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Rohacs, Tibor
AU  - Rohacs T
AD  - Rutgers, New Jersey Medical School, Newark, NJ, USA. Electronic address: 
      rohacsti@njms.rutgers.edu.
LA  - eng
GR  - R01 GM093290/GM/NIGMS NIH HHS/United States
GR  - R01 NS055159/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20151219
PL  - England
TA  - Adv Biol Regul
JT  - Advances in biological regulation
JID - 101572336
RN  - 0 (Ion Channels)
RN  - 0 (Isoenzymes)
RN  - 0 (Phosphatidylinositol 4,5-Diphosphate)
RN  - EC 3.1.4.- (Type C Phospholipases)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/metabolism
MH  - Ganglia, Spinal/cytology/metabolism
MH  - Gene Expression Regulation
MH  - Humans
MH  - Ion Channels/classification/*genetics/metabolism
MH  - Isoenzymes/genetics/metabolism
MH  - Neurons/cytology/*metabolism
MH  - Pain Perception/physiology
MH  - Phosphatidylinositol 4,5-Diphosphate/*metabolism
MH  - Sensory Thresholds/*physiology
MH  - Signal Transduction
MH  - Touch Perception/*physiology
MH  - Trigeminal Ganglion/cytology/metabolism
MH  - Type C Phospholipases/*genetics/metabolism
PMC - PMC4884561
MID - NIHMS746421
EDAT- 2016/01/05 06:00
MHDA- 2017/11/29 06:00
PMCR- 2017/05/01
CRDT- 2016/01/04 06:00
PHST- 2015/10/12 00:00 [received]
PHST- 2015/11/06 00:00 [revised]
PHST- 2015/11/07 00:00 [accepted]
PHST- 2016/01/04 06:00 [entrez]
PHST- 2016/01/05 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - S2212-4926(15)30032-4 [pii]
AID - 10.1016/j.jbior.2015.11.012 [doi]
PST - ppublish
SO  - Adv Biol Regul. 2016 May;61:2-16. doi: 10.1016/j.jbior.2015.11.012. Epub 2015 Dec 
      19.