PMID- 26725915
OWN - NLM
STAT- MEDLINE
DCOM- 20170111
LR  - 20221207
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 94
IP  - 5
DP  - 2016 Aug
TI  - Heat shock protein-70 and hypoxia inducible factor-1alpha in type 2 diabetes mellitus 
      patients complicated with retinopathy.
PG  - e361-6
LID - 10.1111/aos.12919 [doi]
AB  - PURPOSE: To elucidate the role of heat shock protein-70 (HSP70) and hypoxia 
      inducible factor-1alpha (HIF-1alpha) in diabetic retinopathy (DR) patients. DESIGN AND 
      METHODS: A comparative study was done on the serum level of both HSP70 and HIF-1alpha 
      in 50 patients with type 2 diabetes mellitus (T2DM) without DR, 50 patients with 
      T2DM and DR and 70 healthy control subjects. RESULTS: HSP70 and HIF-1alpha were 
      significantly increased in T2DM patients compared to controls and increased in 
      patients with T2DM & DR compared to T2DM patients without DR (p < 0.0001). HSP70 
      did not differ among the patients with different stages of DR, while HIF-1alpha 
      increased significantly in grades 3 and 4 DR patients compared to grades 1 and 2 
      DR patients. A strong correlation was found between HIF-1alpha and the development of 
      DR (r = 0.835, p = 0.00) but not with HSP70. HIF-1alpha can be used as a predictor 
      for development of DR but not HSP70. CONCLUSIONS: Our study was the first that 
      investigated both HSP70 and HIF-1alpha in humans and was the first that measured 
      their levels in serum of patients with DR. The study suggested that HSP70 might 
      have a protective function in T2DM patients rather than a therapeutic function. 
      HIF-1alpha had an upper hand in the development and progression of DR. Induction of 
      HSP70 and blockage of HIF-1alpha could lead to the development of novel prophylactic 
      and therapeutic strategies for DR and potentially other diabetic complications.
CI  - (c) 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Sayed, Khulood M
AU  - Sayed KM
AD  - The Department of Ophthalmology, Faculty of Medicine, Sohag University, Sohag, 
      Egypt.
FAU - Mahmoud, Aida A
AU  - Mahmoud AA
AD  - The Department of Biochemistry, Faculty of Medicine, Sohag University, Sohag, 
      Egypt.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20160104
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (HIF1A protein, human)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Diabetic Retinopathy/*blood/etiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/metabolism
MH  - HSP70 Heat-Shock Proteins/*blood
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*blood
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
OTO - NOTNLM
OT  - Type 2 DM
OT  - diabetic retinopathy
OT  - heat shock protein
OT  - hypoxia inducible factor 1-alpha
EDAT- 2016/01/05 06:00
MHDA- 2017/01/12 06:00
CRDT- 2016/01/05 06:00
PHST- 2015/07/23 00:00 [received]
PHST- 2015/09/27 00:00 [accepted]
PHST- 2016/01/05 06:00 [entrez]
PHST- 2016/01/05 06:00 [pubmed]
PHST- 2017/01/12 06:00 [medline]
AID - 10.1111/aos.12919 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2016 Aug;94(5):e361-6. doi: 10.1111/aos.12919. Epub 2016 Jan 4.