PMID- 26726708
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181023
IS  - 1522-6662 (Electronic)
IS  - 1098-3511 (Linking)
VI  - 18
IP  - 6
DP  - 2015 Nov 5
TI  - Early Outcomes of Pharmacomechanical Thrombectomy in Acute Deep Vein Thrombosis 
      Patients.
PG  - E222-5
LID - 10.1532/hsf.1307 [doi]
AB  - BACKGROUND: Acute lower extremity deep vein thrombosis (DVT) occurs due to 
      obstruction of large veins by thrombus and its clinical findings are pain and 
      swelling. If not treated, it can cause morbidity and mortality. Oral warfarin or 
      low molecular weight heparin are applied in traditional treatment. However, 
      recently, endovascular procedures have gained increasing popularity in deep vein 
      thrombosis. In this study we aimed to compare our early results of 
      pharmacomechanical thrombectomy (PMT) versus oral anticoagulation for acute deep 
      vein thrombosis. METHODS: We comprised 50 patients presented with acute DVT 
      between January 2013 and June 2014, who received either adjusted subcutaneous low 
      molecular weight heparin (LMWH) or PMT followed by intravenous unfractionated 
      heparin (UFH) for 5 days. Warfarin was administered to PMT patients for 3 months 
      and at least 6 months for the control group. RESULTS: Median follow-up was 14 
      months (6-18 months). Recanalization within 6 months was found in 84.0%, femoral 
      venous insufficiency was found in 36.0%, and postthrombotic syndrome (PTS) was 
      found in 28.0% of the patients who received PMT treatment. The mean duration of 
      symptoms was 11.0 days (range, 3-20 days). The mean duration of the procedure was 
      78.1 minutes (range, 55-100 min). CONCLUSION: In contrast to medical therapy in 
      the treatment of deep vein thrombosis, usage of catheter-directed thrombolysis 
      experienced early recanalization with higher thrombus resolution. PMT with 
      adjunctive thrombolytic therapy is an effective treatment modality in patients 
      with significant DVT. Also, early thrombus removal in patients with acute DVT 
      prevents development of postthrombotic morbidity. We believe that the efficacy 
      and usage will increase with the experience of surgeons in the future.
FAU - Ezelsoy, Mehmet
AU  - Ezelsoy M
AD  - Cardiovascular Surgery Department, Antakya State Hospital, Antakya, Turkey.
FAU - Turunc, Gorkem
AU  - Turunc G
AD  - Internal Medicine Department, Istanbul University, Istanbul, Turkey.
FAU - Bayram, Muhammed
AU  - Bayram M
AD  - Cardiovascular Surgery Department, Istanbul Mehmet Akif Ersoy Hospital, Istanbul, 
      Turkey.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20151105
PL  - United States
TA  - Heart Surg Forum
JT  - The heart surgery forum
JID - 100891112
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 5Q7ZVV76EI (Warfarin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anticoagulants/*therapeutic use
MH  - Heparin/therapeutic use
MH  - Heparin, Low-Molecular-Weight/therapeutic use
MH  - Humans
MH  - *Mechanical Thrombolysis
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Venous Thrombosis/drug therapy/*therapy
MH  - Warfarin/therapeutic use
EDAT- 2016/01/05 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/01/05 06:00
PHST- 2015/06/09 00:00 [received]
PHST- 2015/08/10 00:00 [accepted]
PHST- 2015/07/21 00:00 [revised]
PHST- 2016/01/05 06:00 [entrez]
PHST- 2016/01/05 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1532/hsf.1307 [doi]
PST - epublish
SO  - Heart Surg Forum. 2015 Nov 5;18(6):E222-5. doi: 10.1532/hsf.1307.