PMID- 26726800 OWN - NLM STAT- MEDLINE DCOM- 20160706 LR - 20190222 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 11 IP - 1 DP - 2016 TI - Delayed P100-Like Latencies in Multiple Sclerosis: A Preliminary Investigation Using Visual Evoked Spread Spectrum Analysis. PG - e0146084 LID - 10.1371/journal.pone.0146084 [doi] LID - e0146084 AB - Conduction along the optic nerve is often slowed in multiple sclerosis (MS). This is typically assessed by measuring the latency of the P100 component of the Visual Evoked Potential (VEP) using electroencephalography. The Visual Evoked Spread Spectrum Analysis (VESPA) method, which involves modulating the contrast of a continuous visual stimulus over time, can produce a visually evoked response analogous to the P100 but with a higher signal-to-noise ratio and potentially higher sensitivity to individual differences in comparison to the VEP. The main objective of the study was to conduct a preliminary investigation into the utility of the VESPA method for probing and monitoring visual dysfunction in multiple sclerosis. The latencies and amplitudes of the P100-like VESPA component were compared between healthy controls and multiple sclerosis patients, and multiple sclerosis subgroups. The P100-like VESPA component activations were examined at baseline and over a 3-year period. The study included 43 multiple sclerosis patients (23 relapsing-remitting MS, 20 secondary-progressive MS) and 42 healthy controls who completed the VESPA at baseline. The follow-up sessions were conducted 12 months after baseline with 24 MS patients (15 relapsing-remitting MS, 9 secondary-progressive MS) and 23 controls, and again at 24 months post-baseline with 19 MS patients (13 relapsing-remitting MS, 6 secondary-progressive MS) and 14 controls. The results showed P100-like VESPA latencies to be delayed in multiple sclerosis compared to healthy controls over the 24-month period. Secondary-progressive MS patients had most pronounced delay in P100-like VESPA latency relative to relapsing-remitting MS and controls. There were no longitudinal P100-like VESPA response differences. These findings suggest that the VESPA method is a reproducible electrophysiological method that may have potential utility in the assessment of visual dysfunction in multiple sclerosis. FAU - Kiiski, Hanni S M AU - Kiiski HS AD - Neural Engineering Group, Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland. AD - School of Engineering, Trinity College Dublin, Dublin, Ireland. FAU - Ni Riada, Sinead AU - Ni Riada S AD - Neural Engineering Group, Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland. AD - School of Engineering, Trinity College Dublin, Dublin, Ireland. FAU - Lalor, Edmund C AU - Lalor EC AD - Neural Engineering Group, Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland. AD - School of Engineering, Trinity College Dublin, Dublin, Ireland. FAU - Goncalves, Nuno R AU - Goncalves NR AD - Neural Engineering Group, Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland. AD - School of Engineering, Trinity College Dublin, Dublin, Ireland. FAU - Nolan, Hugh AU - Nolan H AD - Neural Engineering Group, Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland. AD - School of Engineering, Trinity College Dublin, Dublin, Ireland. FAU - Whelan, Robert AU - Whelan R AD - Neural Engineering Group, Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland. AD - Cognitive and Behavioural Neuroscience Research Group, School of Psychology, UCD College of Human Sciences, University College Dublin, Dublin, Ireland. FAU - Lonergan, Roisin AU - Lonergan R AD - Department of Neurology, St. Vincent's University Hospital, Dublin, Ireland. FAU - Kelly, Siobhan AU - Kelly S AD - Department of Neurology, St. Vincent's University Hospital, Dublin, Ireland. FAU - O'Brien, Marie Claire AU - O'Brien MC AD - Cognitive and Behavioural Neuroscience Research Group, School of Psychology, UCD College of Human Sciences, University College Dublin, Dublin, Ireland. FAU - Kinsella, Katie AU - Kinsella K AD - Department of Neurology, St. Vincent's University Hospital, Dublin, Ireland. FAU - Bramham, Jessica AU - Bramham J AD - Cognitive and Behavioural Neuroscience Research Group, School of Psychology, UCD College of Human Sciences, University College Dublin, Dublin, Ireland. FAU - Burke, Teresa AU - Burke T AD - Cognitive and Behavioural Neuroscience Research Group, School of Psychology, UCD College of Human Sciences, University College Dublin, Dublin, Ireland. AD - School of Nursing and Human Sciences, Dublin City University, Dublin, Ireland. FAU - O Donnchadha, Sean AU - O Donnchadha S AD - Cognitive and Behavioural Neuroscience Research Group, School of Psychology, UCD College of Human Sciences, University College Dublin, Dublin, Ireland. FAU - Hutchinson, Michael AU - Hutchinson M AD - Department of Neurology, St. Vincent's University Hospital, Dublin, Ireland. FAU - Tubridy, Niall AU - Tubridy N AD - Department of Neurology, St. Vincent's University Hospital, Dublin, Ireland. FAU - Reilly, Richard B AU - Reilly RB AD - Neural Engineering Group, Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland. AD - School of Engineering, Trinity College Dublin, Dublin, Ireland. AD - School of Medicine, Trinity College Dublin, Dublin, Ireland. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160104 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adult MH - Cross-Sectional Studies MH - Disease Progression MH - Electroencephalography MH - *Evoked Potentials, Visual MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Middle Aged MH - Multiple Sclerosis/complications/*physiopathology MH - Optic Nerve/*physiopathology MH - Optic Neuritis/etiology/physiopathology MH - Reaction Time MH - Spectrum Analysis/methods PMC - PMC4699709 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2016/01/05 06:00 MHDA- 2016/07/07 06:00 PMCR- 2016/01/04 CRDT- 2016/01/05 06:00 PHST- 2015/05/15 00:00 [received] PHST- 2015/12/11 00:00 [accepted] PHST- 2016/01/05 06:00 [entrez] PHST- 2016/01/05 06:00 [pubmed] PHST- 2016/07/07 06:00 [medline] PHST- 2016/01/04 00:00 [pmc-release] AID - PONE-D-15-21163 [pii] AID - 10.1371/journal.pone.0146084 [doi] PST - epublish SO - PLoS One. 2016 Jan 4;11(1):e0146084. doi: 10.1371/journal.pone.0146084. eCollection 2016.