PMID- 26731566
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1423-0372 (Electronic)
IS  - 1011-6125 (Linking)
VI  - 93
IP  - 6
DP  - 2015
TI  - Long-Term Changes in Drug Craving and Nutritional Status of Opioid Addicts with 
      Nucleus Accumbens Ablative Stereotactic Neurosurgery at Five Years 
      Postoperatively.
PG  - 407-14
LID - 10.1159/000441392 [doi]
AB  - BACKGROUND: The nucleus accumbens (NAcc) has been proven to be associated with 
      drug and food craving. NAcc ablative neurosurgery has been suggested to modulate 
      the balance of the brain reward system and thus alleviate drug dependence in 
      patients. It has been hypothesized that it would also alleviate food craving in 
      patients as well as altering their nutritional status. AIMS: This study aimed to 
      estimate the effect of NAcc neurosurgery on drug craving and nutritional status 
      in patients with drug dependence at 5 years postoperatively. METHODS: The study 
      included 100 patients with NAcc surgery and 92 patients without surgery. Body 
      mass index (BMI) and body fat percentage (BF%) were examined to assess 
      nutritional status, and questionnaires were administered to assess drug craving. 
      RESULTS: Compared with the nonsurgery group and the relapse patients from the 
      surgery group, the nonrelapse patients from the surgery group had higher BMI and 
      BF% but lower drug craving. There were no significant differences between the 
      nonsurgery group and the relapse patients in BMI, but the relapse patients had 
      higher drug craving than the nonsurgery group. CONCLUSIONS: Long-term follow-up 
      suggested that NAcc ablative neurosurgery would alleviate drug craving and yield 
      a better nutritional status if individuals sustained abstinence. It would 
      increase drug craving but would not ruin the nutritional status of patients even 
      when individuals relapsed postoperatively.
CI  - (c) 2016 S. Karger AG, Basel.
FAU - Wu, He-Ming
AU  - Wu HM
AD  - Department of Neurosurgery, Jingdu Hospital, Nanjing, PR China.
FAU - Ge, Shun-Nan
AU  - Ge SN
FAU - Dai, Hai-Bin
AU  - Dai HB
FAU - Wang, Ling
AU  - Wang L
FAU - Chang, Chong-Wang
AU  - Chang CW
FAU - Wang, Xue-Lian
AU  - Wang XL
FAU - Li, Nan
AU  - Li N
FAU - Gao, Guo-Dong
AU  - Gao GD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160106
PL  - Switzerland
TA  - Stereotact Funct Neurosurg
JT  - Stereotactic and functional neurosurgery
JID - 8902881
SB  - IM
MH  - Adult
MH  - *Craving
MH  - Female
MH  - Humans
MH  - Male
MH  - Neurosurgical Procedures/*methods
MH  - Nucleus Accumbens/*surgery
MH  - Nutritional Status
MH  - Opioid-Related Disorders/psychology/*surgery
MH  - Postoperative Period
MH  - Treatment Outcome
EDAT- 2016/01/06 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/01/06 06:00
PHST- 2014/12/10 00:00 [received]
PHST- 2015/09/30 00:00 [accepted]
PHST- 2016/01/06 06:00 [entrez]
PHST- 2016/01/06 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 000441392 [pii]
AID - 10.1159/000441392 [doi]
PST - ppublish
SO  - Stereotact Funct Neurosurg. 2015;93(6):407-14. doi: 10.1159/000441392. Epub 2016 
      Jan 6.