PMID- 26731572
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 65
DP  - 2016 Mar
TI  - Association of peripheral inflammation with body mass index and depressive 
      relapse in bipolar disorder.
PG  - 76-83
LID - S0306-4530(15)30031-7 [pii]
LID - 10.1016/j.psyneuen.2015.12.012 [doi]
AB  - Bipolar I disorder (BD) is associated with increased inflammation, which is 
      believed to be central to disease etiology and progression. However, BD patients 
      also have high rates of obesity, itself an inflammatory condition, and the 
      relative contributions of mood illness and obesity to inflammation are unknown. 
      Moreover, the impact of inflammation on clinical illness course has not been well 
      studied. The objectives of this analysis were therefore: (1) to determine if 
      inflammation in BD is mood illness-related or secondary to elevated body mass 
      index (BMI), and (2) to investigate the impact of inflammation on 
      prospectively-ascertained relapse into depression and mania. We measured the 
      serum levels of 7 inflammatory cytokines (TNF-alpha, gamma-interferon, monocyte 
      chemoattractant protein-1 [MCP-1], IL-1alpha, IL-2, IL-6, and IL-8) and 2 
      anti-inflammatory cytokines (IL-4 and IL-10) in 52 early-stage BD patients and 22 
      healthy subjects. In patients, a multivariate multiple regression model that 
      controlled for psychotropic medications found that higher BMI, but not recent 
      (past-6-month) mood episodes, predicted greater inflammatory cytokines (p=.05). 
      Healthy subjects also had a BMI-related increase in inflammatory cytokines 
      (p<.01), but it was counter-balanced by a compensatory increase in 
      anti-inflammatory cytokines (p=.02), reducing their total inflammatory burden 
      from higher BMI. In patients, linear regression showed that two inflammatory 
      cytokines predicted depressive relapse in the 12 months after cytokine 
      measurement: IL-1alpha (p<.01) and MCP-1 (p<.01). These results suggest that elevated 
      BMI is a significant contributor to inflammation in BD, more so even than recent 
      mood illness severity. They also point to inflammation as an important predictor 
      of illness course, particularly depressive relapse.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Bond, David J
AU  - Bond DJ
AD  - Mood Disorders Centre, University of British Columbia, 2255 Wesbrook Mall, 
      Vancouver, BC V6T 2A1, Canada; Department of Psychiatry, University of Minnesota, 
      2450 Riverside Avenue, Minneapolis, MN 55454, USA.
FAU - Andreazza, Ana C
AU  - Andreazza AC
AD  - Departments of Psychiatry and Pharmacology, University of Toronto, 250 College 
      Street, Toronto, ON M5T 1R8, Canada.
FAU - Hughes, John
AU  - Hughes J
AD  - Division of Biostatistics, University of Minnesota School of Public Health, 420 
      Delaware Street, Minneapolis, MN 55455, USA.
FAU - Dhanoa, Taj
AU  - Dhanoa T
AD  - Mood Disorders Centre, University of British Columbia, 2255 Wesbrook Mall, 
      Vancouver, BC V6T 2A1, Canada.
FAU - Torres, Ivan J
AU  - Torres IJ
AD  - Mood Disorders Centre, University of British Columbia, 2255 Wesbrook Mall, 
      Vancouver, BC V6T 2A1, Canada.
FAU - Kozicky, Jan-Marie
AU  - Kozicky JM
AD  - Mood Disorders Centre, University of British Columbia, 2255 Wesbrook Mall, 
      Vancouver, BC V6T 2A1, Canada.
FAU - Young, L Trevor
AU  - Young LT
AD  - Departments of Psychiatry and Pharmacology, University of Toronto, 250 College 
      Street, Toronto, ON M5T 1R8, Canada.
FAU - Lam, Raymond W
AU  - Lam RW
AD  - Mood Disorders Centre, University of British Columbia, 2255 Wesbrook Mall, 
      Vancouver, BC V6T 2A1, Canada.
FAU - Yatham, Lakshmi N
AU  - Yatham LN
AD  - Mood Disorders Centre, University of British Columbia, 2255 Wesbrook Mall, 
      Vancouver, BC V6T 2A1, Canada. Electronic address: yatham@mail.ubc.ca.
LA  - eng
PT  - Journal Article
DEP - 20151218
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Cytokines)
SB  - IM
MH  - Affect/physiology
MH  - Bipolar Disorder/blood/*immunology/pathology/psychology
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cytokines/blood/immunology
MH  - Depressive Disorder/blood/*immunology/pathology/psychology
MH  - Female
MH  - Humans
MH  - Inflammation/blood/immunology/pathology/*psychology
MH  - Male
MH  - Obesity/blood/immunology/pathology
MH  - Recurrence
MH  - Young Adult
OTO - NOTNLM
OT  - Bipolar disorder
OT  - Body mass index
OT  - Cytokines
OT  - Inflammation
OT  - Obesity
OT  - Relapse
EDAT- 2016/01/06 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/01/06 06:00
PHST- 2015/08/14 00:00 [received]
PHST- 2015/12/14 00:00 [revised]
PHST- 2015/12/14 00:00 [accepted]
PHST- 2016/01/06 06:00 [entrez]
PHST- 2016/01/06 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0306-4530(15)30031-7 [pii]
AID - 10.1016/j.psyneuen.2015.12.012 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2016 Mar;65:76-83. doi: 10.1016/j.psyneuen.2015.12.012. 
      Epub 2015 Dec 18.