PMID- 26731836
OWN - NLM
STAT- MEDLINE
DCOM- 20160209
LR  - 20160106
IS  - 0004-5772 (Print)
IS  - 0004-5772 (Linking)
VI  - 63
IP  - 7
DP  - 2015 Jul
TI  - Idiopathic Pyoderma Gangrenosum as a Novel Manifestation of the HIV Immune 
      Reconstitution Inflammatory Syndrome: A Report of Three Cases.
PG  - 72-6
AB  - The initiation of antiretroviral treatment for individuals with HIV may be 
      accompanied by a paradoxical flare of underlying inflammatory diseases, the 
      recurrence of dormant infections, or worsening of prior treated opportunistic 
      infections, termed the immune reconstitution inflammatory syndrome (IRIS). 
      Cutaneous manifestations of IRIS are common. Pyoderma gangrenosum is a 
      neutrophilic dermatosis postulated to reflect disrupted innate immune regulation 
      causing altered neutrophil chemotaxis. It is uncommonly reported in association 
      with HIV. In this case series, we present three cases of IRIS manifesting with 
      pyoderma gangrenosum in individuals with HIV from India and the United States to 
      raise awareness of this previously undescribed presentation and discuss the 
      treatment challenges in the management of these patients.
FAU - Nambudiri, Vinod E
AU  - Nambudiri VE
FAU - Kersellius, Romona
AU  - Kersellius R
FAU - Harp, Joanna
AU  - Harp J
FAU - Maniar, J K
AU  - Maniar JK
FAU - Maurer, Toby A
AU  - Maurer TA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - India
TA  - J Assoc Physicians India
JT  - The Journal of the Association of Physicians of India
JID - 7505585
SB  - IM
MH  - Adult
MH  - Female
MH  - HIV Infections/*complications/pathology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*pathology/*virology
MH  - Male
MH  - Middle Aged
MH  - Pyoderma Gangrenosum/*pathology/*virology
EDAT- 2016/01/07 06:00
MHDA- 2016/02/10 06:00
CRDT- 2016/01/07 06:00
PHST- 2016/01/07 06:00 [entrez]
PHST- 2016/01/07 06:00 [pubmed]
PHST- 2016/02/10 06:00 [medline]
PST - ppublish
SO  - J Assoc Physicians India. 2015 Jul;63(7):72-6.