PMID- 26732457
OWN - NLM
STAT- MEDLINE
DCOM- 20161006
LR  - 20181113
IS  - 1928-9022 (Electronic)
IS  - 0830-9000 (Print)
IS  - 0830-9000 (Linking)
VI  - 80
IP  - 1
DP  - 2016 Jan
TI  - Efficacy of Fostera PRRS modified live virus vaccine against a Canadian 
      heterologous virulent field strain of porcine reproductive and respiratory 
      syndrome virus.
PG  - 1-11
AB  - Vaccination is a useful option to control infection with porcine reproductive and 
      respiratory syndrome virus (PRRSV), and several modified live-PRRSV vaccines have 
      been developed. These vaccines have shown some efficacy in reducing the incidence 
      and severity of clinical disease as well as the duration of viremia and virus 
      shedding but have failed to provide sterilizing immunity. The efficacy of 
      modified live-virus (MLV) vaccines is greater against a homologous strain 
      compared with heterologous PRRSV strains. The objective of this study was to 
      evaluate the efficacy of Fostera PRRS MLV vaccine in protecting against challenge 
      with a heterologous field strain widely circulating in the swine herds of eastern 
      Canada. Forty-six piglets were divided into 4 groups: 
      nonvaccinated-nonchallenged; nonvaccinated-challenged; vaccinated-challenged; and 
      vaccinated-nonchallenged. The animals were vaccinated at 23 d of age with Fostera 
      PRRS and challenged 23 d later with a heterologous field strain of PRRSV 
      (FMV12-1425619). Overall, the vaccine showed some beneficial effects in the 
      challenged animals by reducing the severity of clinical signs and the viral load. 
      A significant difference between nonvaccinated and vaccinated animals was 
      detected for some parameters starting 11 to 13 d after challenge, which suggested 
      that the cell-mediated immune response or other delayed responses could be more 
      important than pre-existing PRRSV antibodies in vaccinated animals within the 
      context of protection against heterologous strains.
FAU - Savard, Christian
AU  - Savard C
AD  - Swine and Poultry Infectious Diseases Research Center and The Research Group on 
      Infectious Diseases of Swine, Faculte de medecine veterinaire, Universite de 
      Montreal, 3200, rue Sicotte, Saint-Hyacinthe, Quebec J2S 7C6.
FAU - Alvarez, Fernando
AU  - Alvarez F
AD  - Swine and Poultry Infectious Diseases Research Center and The Research Group on 
      Infectious Diseases of Swine, Faculte de medecine veterinaire, Universite de 
      Montreal, 3200, rue Sicotte, Saint-Hyacinthe, Quebec J2S 7C6.
FAU - Provost, Chantale
AU  - Provost C
AD  - Swine and Poultry Infectious Diseases Research Center and The Research Group on 
      Infectious Diseases of Swine, Faculte de medecine veterinaire, Universite de 
      Montreal, 3200, rue Sicotte, Saint-Hyacinthe, Quebec J2S 7C6.
FAU - Chorfi, Younes
AU  - Chorfi Y
AD  - Swine and Poultry Infectious Diseases Research Center and The Research Group on 
      Infectious Diseases of Swine, Faculte de medecine veterinaire, Universite de 
      Montreal, 3200, rue Sicotte, Saint-Hyacinthe, Quebec J2S 7C6.
FAU - D'Allaire, Sylvie
AU  - D'Allaire S
AD  - Swine and Poultry Infectious Diseases Research Center and The Research Group on 
      Infectious Diseases of Swine, Faculte de medecine veterinaire, Universite de 
      Montreal, 3200, rue Sicotte, Saint-Hyacinthe, Quebec J2S 7C6.
FAU - Benoit-Biancamano, Marie-Odile
AU  - Benoit-Biancamano MO
AD  - Swine and Poultry Infectious Diseases Research Center and The Research Group on 
      Infectious Diseases of Swine, Faculte de medecine veterinaire, Universite de 
      Montreal, 3200, rue Sicotte, Saint-Hyacinthe, Quebec J2S 7C6.
FAU - Gagnon, Carl A
AU  - Gagnon CA
AD  - Swine and Poultry Infectious Diseases Research Center and The Research Group on 
      Infectious Diseases of Swine, Faculte de medecine veterinaire, Universite de 
      Montreal, 3200, rue Sicotte, Saint-Hyacinthe, Quebec J2S 7C6.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Can J Vet Res
JT  - Canadian journal of veterinary research = Revue canadienne de recherche 
      veterinaire
JID - 8607793
RN  - 0 (Antibodies, Viral)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Antibody Specificity
MH  - Canada/epidemiology
MH  - Gene Expression Regulation, Viral
MH  - Molecular Sequence Data
MH  - Open Reading Frames/genetics
MH  - Porcine Reproductive and Respiratory Syndrome/epidemiology/*prevention & 
      control/virology
MH  - Porcine respiratory and reproductive syndrome virus/*pathogenicity
MH  - Swine
MH  - Viral Vaccines/*immunology
MH  - Virulence
PMC - PMC4686029
EDAT- 2016/01/07 06:00
MHDA- 2016/10/08 06:00
PMCR- 2016/07/01
CRDT- 2016/01/07 06:00
PHST- 2016/01/07 06:00 [entrez]
PHST- 2016/01/07 06:00 [pubmed]
PHST- 2016/10/08 06:00 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - cjvr_01_1 [pii]
PST - ppublish
SO  - Can J Vet Res. 2016 Jan;80(1):1-11.