PMID- 26734458
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160106
LR  - 20240324
IS  - 2050-4527 (Print)
IS  - 2050-4527 (Electronic)
IS  - 2050-4527 (Linking)
VI  - 3
IP  - 4
DP  - 2015 Dec
TI  - A2B adenosine receptor activation switches differentiation of bone marrow cells 
      to a CD11c(+)Gr-1(+) dendritic cell subset that promotes the Th17 response.
PG  - 360-73
LID - 10.1002/iid3.74 [doi]
AB  - Adenosine is one of the major molecules associated with inflammation. We have 
      previously reported that an adenosine receptor (AR) agonist has an enhancing 
      effect on Th17 autoimmune responses, even though it suppressed Th1 responses. To 
      determine the mechanism involved, we have examined the effect of AR agonists on 
      mouse bone marrow dendritic cell (BMDC) differentiation and function. We show 
      that mouse bone marrow cells (BMCs) differentiated into CD11c(+)Gr-1(+) dentritic 
      cells (DCs) when cultured in granulocyte macrophage colony-stimulating factor 
      (GM-CSF)-containing medium containing an AR agonist. The non-selective AR agonist 
      NECA and an A2BR-specific agonist had a similar effect, and the effect of NECA 
      could be blocked by an A2BR-specific antagonist. Unlike CD11c(+)Gr-1(-) BMDCs, 
      which have a greater stimulatory effect on Th1 T cells than Th17 cells, 
      CD11c(+)Gr-1(+) BMDCs had a greater stimulatory effect on Th17 autoreactive T 
      cells than on Th1 autoreactive T cells and this effect depended on gammadelta T cell 
      activation.
FAU - Liang, Dongchun
AU  - Liang D
AD  - Department of Ophthalmology of the University of California Los Angeles Doheny 
      Eye Institute California 90033 USA.
FAU - Zuo, Aijun
AU  - Zuo A
AD  - Department of Ophthalmology of the University of California Los Angeles Doheny 
      Eye Institute California 90033 USA.
FAU - Shao, Hui
AU  - Shao H
AD  - Department of Ophthalmology and Visual Sciences Kentucky Lions Eye Center 
      University of Louisville Louisville Kentucky 40202 USA.
FAU - Chen, Mingjiazi
AU  - Chen M
AD  - Department of Ophthalmology of the University of California Los Angeles Doheny 
      Eye Institute California 90033 USA.
FAU - Kaplan, Henry J
AU  - Kaplan HJ
AD  - Department of Ophthalmology and Visual Sciences Kentucky Lions Eye Center 
      University of Louisville Louisville Kentucky 40202 USA.
FAU - Sun, Deming
AU  - Sun D
AD  - Department of Ophthalmology of the University of California Los Angeles Doheny 
      Eye Institute California 90033 USA.
LA  - eng
GR  - R01 EY018827/EY/NEI NIH HHS/United States
GR  - R01 EY022403/EY/NEI NIH HHS/United States
PT  - Journal Article
DEP - 20150730
PL  - England
TA  - Immun Inflamm Dis
JT  - Immunity, inflammation and disease
JID - 101635460
PMC - PMC4693722
OTO - NOTNLM
OT  - Adenosine receptors
OT  - IL-17
OT  - Th17
OT  - autoimmunity
OT  - experimental autoimmune uveitis
OT  - uveitis
OT  - gammadelta T cells
EDAT- 2016/01/07 06:00
MHDA- 2016/01/07 06:01
PMCR- 2015/07/30
CRDT- 2016/01/07 06:00
PHST- 2015/03/02 00:00 [received]
PHST- 2015/05/21 00:00 [revised]
PHST- 2015/06/30 00:00 [accepted]
PHST- 2016/01/07 06:00 [entrez]
PHST- 2016/01/07 06:00 [pubmed]
PHST- 2016/01/07 06:01 [medline]
PHST- 2015/07/30 00:00 [pmc-release]
AID - IID374 [pii]
AID - 10.1002/iid3.74 [doi]
PST - epublish
SO  - Immun Inflamm Dis. 2015 Jul 30;3(4):360-73. doi: 10.1002/iid3.74. eCollection 
      2015 Dec.