PMID- 26735639
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160108
LR  - 20160107
IS  - 1355-6215 (Print)
IS  - 1355-6215 (Linking)
VI  - 2
IP  - 2
DP  - 1997 Apr
TI  - Involvement of CNS cholinergic systems in alcohol drinking of P rats.
PG  - 215-23
LID - 10.1080/13556219772769 [doi]
AB  - Experiments were undertaken to determine if CNS muscarinic- and 
      nicotinic-cholinergic receptors are involved in regulating alcohol drinking of 
      rats from the selectively-bred alcohol-preferring P line. Intracerebroventricular 
      (i.c.v.) drug infusions were administered into the lateral ventricle of female P 
      rats 15 minutes before ethanol access. The muscarinic antagonists pirenzepine and 
      scopolamine were tested on limited access (4 hours/day) to a 10% (v/v) ethanol 
      solution. Food and water were available ad libitum. Nicotine and the nicotinic 
      antagonist mecamylamine were tested on limited access (4 hours/day) to 10% (v/v) 
      ethanol and 0.0125% saccharin solutions. Food was available ad libitum and water 
      was available during the remaining 20 hours. The baseline ethanol intakes ranged 
      between an average of 3.0 +/- 0.3 g/kg/4 hours and 3.4 +/- 0.3 g/kg/4 hours. 
      Administration of 40-100 m g pirenzepine (M1-selective antagonist) had no effect 
      on ethanol, food or water consumption. However, 20-80 m g scopolamine, a 
      non-selective muscarinic antagonist, dosedependently decreased ethanol intake as 
      much as 60% (p < 0.05) without altering food or water consumption. The nicotinic 
      antagonist mecamylamine (20-120 m g) did not alter ethanol intake, but nicotine 
      (40-80 m g) dose-dependently decreased ethanol drinking as much as 60% within the 
      first 30 minutes (p < 0.05) without an effect on saccharin intake. The results 
      suggest that: (a), muscarinic receptors, with the possible exception of the M1 
      subtype, are involved in regulating alcohol drinking and (b), activation of 
      nicotinic receptors can reduce alcohol drinking of the P line of rats.
FAU - Katner, S N
AU  - Katner SN
AD  - Program in Medical Neurobiology, Institute of Psychiatric Research, Departments 
      of Psychiatry, Medicine and Biochemistry, Indiana University School of Medicine 
      and VA Medical Center & Department of Psychology, Purdue School of Science, 
      Indiana University-Purdue University, Indianapolis, USA.
FAU - McBRIDE, W J
AU  - McBRIDE WJ
AD  - Program in Medical Neurobiology, Institute of Psychiatric Research, Departments 
      of Psychiatry, Medicine and Biochemistry, Indiana University School of Medicine 
      and VA Medical Center & Department of Psychology, Purdue School of Science, 
      Indiana University-Purdue University, Indianapolis, USA.
FAU - Lumeng, L
AU  - Lumeng L
AD  - Program in Medical Neurobiology, Institute of Psychiatric Research, Departments 
      of Psychiatry, Medicine and Biochemistry, Indiana University School of Medicine 
      and VA Medical Center & Department of Psychology, Purdue School of Science, 
      Indiana University-Purdue University, Indianapolis, USA.
FAU - Li, T K
AU  - Li TK
AD  - Program in Medical Neurobiology, Institute of Psychiatric Research, Departments 
      of Psychiatry, Medicine and Biochemistry, Indiana University School of Medicine 
      and VA Medical Center & Department of Psychology, Purdue School of Science, 
      Indiana University-Purdue University, Indianapolis, USA.
FAU - Murphy, J M
AU  - Murphy JM
AD  - Program in Medical Neurobiology, Institute of Psychiatric Research, Departments 
      of Psychiatry, Medicine and Biochemistry, Indiana University School of Medicine 
      and VA Medical Center & Department of Psychology, Purdue School of Science, 
      Indiana University-Purdue University, Indianapolis, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 2016/01/07 06:00
PHST- 2016/01/07 06:00 [entrez]
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
AID - 10.1080/13556219772769 [doi]
PST - ppublish
SO  - Addict Biol. 1997 Apr;2(2):215-23. doi: 10.1080/13556219772769.