PMID- 26739449
OWN - NLM
STAT- MEDLINE
DCOM- 20170328
LR  - 20190606
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 22
DP  - 2016 Jan 7
TI  - Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity but not 
      to Genetic Polymorphisms within BDNF Encoding Gene in Patients with Type 2 
      Diabetes.
PG  - 69-76
AB  - BACKGROUND: The aim of this study was to investigate the association between 
      serum concentrations of the brain-derived neurotrophic factor (BDNF), platelet 
      reactivity and inflammatory markers, as well as its association with BDNF 
      encoding gene variants in type 2 diabetic patients (T2DM) during acetylsalicylic 
      acid (ASA) therapy. MATERIAL/METHODS: This retrospective, open-label study 
      enrolled 91 patients. Serum BDNF, genotype variants, hematological, biochemical, 
      and inflammatory markers were measured. Blood samples were taken in the morning 
      2-3 h after the last ASA dose. The BDNF genotypes for selected variants were 
      analyzed by use of the iPLEX Sequenom assay. RESULTS: In multivariate linear 
      regression analysis, CADP-CT >74 sec (p<0.001) and sP-selectin concentration 
      (p=0.03) were predictive of high serum BDNF. In multivariate logistic regression 
      analysis, CADP-CT >74 sec (p=0.02) and IL-6 concentration (p=0.03) were risk 
      factors for serum BDNF above the median. Non-significant differences were 
      observed between intronic SNP rs925946, missense SNP rs6265, and intronic SNP 
      rs4923463 allelic groups and BDNF concentrations in the investigated cohort. 
      CONCLUSIONS: Chronic inflammatory condition and enhanced immune system are 
      associated with the production of BDNF, which may be why the serum BDNF level in 
      T2DM patients with high platelet reactivity was higher compared to subjects with 
      normal platelet reactivity in this study.
FAU - Eyileten, Ceren
AU  - Eyileten C
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Center for Preclinical Research and Technology CEPT, Warsaw, Poland.
FAU - Zaremba, Malgorzata
AU  - Zaremba M
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Center for Preclinical Research and Technology CEPT, Warsaw, Poland.
FAU - Janicki, Piotr K
AU  - Janicki PK
AD  - Perioperative Genomics Laboratory, Penn State University, College of Medicine, 
      Hershey, PA, USA.
FAU - Rosiak, Marek
AU  - Rosiak M
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Center for Preclinical Research and Technology CEPT, Warsaw, Poland.
FAU - Cudna, Agnieszka
AU  - Cudna A
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Center for Preclinical Research and Technology CEPT, Warsaw, Poland.
FAU - Kaplon-Cieslicka, Agnieszka
AU  - Kaplon-Cieslicka A
AD  - Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
FAU - Opolski, Grzegorz
AU  - Opolski G
AD  - Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
FAU - Filipiak, Krzysztof J
AU  - Filipiak KJ
AD  - Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
FAU - Kosior, Dariusz A
AU  - Kosior DA
AD  - Department of Cardiology and Hypertension, Central Clinical Hospital, The 
      Ministry of the Interior, Warsaw, Poland.
FAU - Mirowska-Guzel, Dagmara
AU  - Mirowska-Guzel D
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Center for Preclinical Research and Technology CEPT, Warsaw, Poland.
FAU - Postula, Marek
AU  - Postula M
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Center for Preclinical Research and Technology CEPT, Warsaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20160107
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (P-Selectin)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Aspirin/therapeutic use
MH  - Blood Platelets/*cytology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Diabetes Mellitus, Type 2/*blood/*genetics
MH  - Female
MH  - Gene Expression Regulation
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Inflammation/blood
MH  - Interleukin-6/blood
MH  - Introns
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Mutation, Missense
MH  - P-Selectin/blood
MH  - Platelet Activation
MH  - Platelet Function Tests
MH  - *Polymorphism, Single Nucleotide
MH  - Prospective Studies
MH  - Quality Control
MH  - Retrospective Studies
PMC - PMC4710194
EDAT- 2016/01/08 06:00
MHDA- 2017/03/30 06:00
PMCR- 2016/01/07
CRDT- 2016/01/08 06:00
PHST- 2016/01/08 06:00 [entrez]
PHST- 2016/01/08 06:00 [pubmed]
PHST- 2017/03/30 06:00 [medline]
PHST- 2016/01/07 00:00 [pmc-release]
AID - 895607 [pii]
AID - 10.12659/msm.895607 [doi]
PST - epublish
SO  - Med Sci Monit. 2016 Jan 7;22:69-76. doi: 10.12659/msm.895607.