PMID- 26740229
OWN - NLM
STAT- MEDLINE
DCOM- 20171013
LR  - 20190610
IS  - 1863-2661 (Electronic)
IS  - 1863-2653 (Linking)
VI  - 221
IP  - 9
DP  - 2016 Dec
TI  - Tyrosine hydroxylase localization in the nucleus accumbens in schizophrenia.
PG  - 4451-4458
AB  - The nucleus accumbens (NAcc) has been implicated in schizophrenia (SZ) pathology, 
      based on antipsychotic action therein. However, recent imaging studies suggest 
      that the NAcc may not be a locus of dopamine dysregulation in SZ. This study 
      examined postmortem human tissue to determine if abnormalities are present in 
      dopamine synthesis in the NAcc in SZ. We compared the immunohistochemical 
      localization of tyrosine hydroxylase (TH), the rate-limiting synthesizing enzyme 
      of dopamine, in postmortem tissue from SZ subjects and demographically matched 
      controls. To study the effects of chronic antipsychotic drug (APD) treatment on 
      TH immunolabeling in the NAcc, rats were treated for 6 months with haloperidol or 
      olanzapine. In the NAcc, TH immunolabeling was similar in control and SZ 
      subjects, in both the core and shell. Rats had similar TH optical density levels 
      across treatment groups in both the core and shell. Similar levels of TH suggest 
      DA synthesis may be normal. These findings provide further insight into the role 
      of the NAcc in SZ.
FAU - McCollum, Lesley A
AU  - McCollum LA
AD  - Department of Psychiatry and Behavioral Neurobiology, University of Alabama at 
      Birmingham, Sparks Center 865D, 1720 2nd Avenue South, Birmingham, AL, 35294, 
      USA.
FAU - McCullumsmith, Robert E
AU  - McCullumsmith RE
AD  - Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, 
      Cincinnati, USA.
FAU - Roberts, Rosalinda C
AU  - Roberts RC
AD  - Department of Psychiatry and Behavioral Neurobiology, University of Alabama at 
      Birmingham, Sparks Center 865D, 1720 2nd Avenue South, Birmingham, AL, 35294, 
      USA. rcusidor@uab.edu.
LA  - eng
GR  - F31 MH098566/MH/NIMH NIH HHS/United States
GR  - R01 MH060744/MH/NIMH NIH HHS/United States
GR  - R01 MH066123/MH/NIMH NIH HHS/United States
GR  - R21 MH087752/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20160106
PL  - Germany
TA  - Brain Struct Funct
JT  - Brain structure & function
JID - 101282001
RN  - 0 (Antipsychotic Agents)
RN  - 12794-10-4 (Benzodiazepines)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - J6292F8L3D (Haloperidol)
RN  - N7U69T4SZR (Olanzapine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antipsychotic Agents/administration & dosage
MH  - Benzodiazepines/administration & dosage
MH  - Dopamine/*metabolism
MH  - Female
MH  - Haloperidol/administration & dosage
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Olanzapine
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Schizophrenia/*metabolism
MH  - Tyrosine 3-Monooxygenase/*metabolism
OTO - NOTNLM
OT  - Anatomy
OT  - Antipsychotics
OT  - Dopamine
OT  - Postmortem
OT  - Ventral striatum
EDAT- 2016/01/08 06:00
MHDA- 2017/10/14 06:00
CRDT- 2016/01/08 06:00
PHST- 2015/06/05 00:00 [received]
PHST- 2015/12/17 00:00 [accepted]
PHST- 2016/01/08 06:00 [pubmed]
PHST- 2017/10/14 06:00 [medline]
PHST- 2016/01/08 06:00 [entrez]
AID - 10.1007/s00429-015-1174-9 [pii]
AID - 10.1007/s00429-015-1174-9 [doi]
PST - ppublish
SO  - Brain Struct Funct. 2016 Dec;221(9):4451-4458. doi: 10.1007/s00429-015-1174-9. 
      Epub 2016 Jan 6.