PMID- 26740337
OWN - NLM
STAT- MEDLINE
DCOM- 20180123
LR  - 20181113
IS  - 1476-5527 (Electronic)
IS  - 0950-9240 (Linking)
VI  - 30
IP  - 11
DP  - 2016 Nov
TI  - Renal and cardiovascular risk predictive value of two different microalbuminuria 
      screening methods in patients with hypertension with/without diabetes in 
      Portugal.
PG  - 726-730
LID - 10.1038/jhh.2015.120 [doi]
AB  - MicRoAlbuminuria sCreening survEy (RACE) was a multicentre, observational, 
      cross-sectional study conducted in primary health-care settings of Portugal. 
      Here, we present a post-hoc analysis from the RACE study, assessing the renal and 
      cardiovascular (CV) risk predictive value of two different microalbuminuria (MA) 
      screening methods, nephelometry with 24-h urine (MA-24 h) and Micral test with 
      occasional urine (MicralA) in patients with hypertension (HTN) with/without type 
      2 diabetes mellitus (T2DM). Out of 3065 patients, 1173 (38.3%) were in the HTN 
      group without T2DM (HTN) and 1892 (61.7%) in the HTN group with T2DM (HTN+T2DM). 
      The overall prevalence of MA was 50.6% determined by MicralA and 22.1% with 
      MA-24 h. Urinary albumin excretion data obtained by both techniques correlated 
      significantly (r(s)=0.586; P<0.001). In all subjects, MicralA showed a 
      sensitivity of 93%, specificity of 62% for detection of MA, with a positive 
      predictive value of 41% and negative predictive value of 97%. With both methods, 
      the presence of MA was independently associated with a higher risk (1.5- to 
      2.9-fold) of CV and renal organ damage in both HTN and HTN+T2DM groups. MicralA, 
      due to its high sensitivity and negative predictive value, can be considered as a 
      valid and reliable method for MA screening in patients with HTN with/without 
      T2DM.
FAU - Polonia, J
AU  - Polonia J
AD  - Department of Medicine, CINTESIS, Faculty of Medicine University of Porto, 
      Hospital Pedro Hispano, Oporto, Portugal.
FAU - Carvalho, D
AU  - Carvalho D
AD  - Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar de S 
      Joao, Faculty of Medicine University of Porto, Instituto de Investigacao e 
      Inovacao em Saude, Universidade do Porto, Porto, Portugal.
FAU - Nazare, J
AU  - Nazare J
AD  - Department of Cardiology, CHLO-Hospital de Egas Moniz, Lisbon, Portugal.
FAU - Martins, L
AU  - Martins L
AD  - Department of Cardiology, Hospital Santa Maria da Feira, Santa Maria da Feira, 
      Portugal.
FAU - da Silva, P M
AU  - da Silva PM
AD  - Department of Internal Medicine, Arterial Investigation Unit, Hospital de Santa 
      Marta, Lisbon, Portugal.
FAU - Aguiar, C
AU  - Aguiar C
AD  - Department of Cardiology, Hospital de Santa Cruz, Carnaxide, Portugal.
FAU - Manso, M C
AU  - Manso MC
AD  - Faculty of Health Sciences, Universidade Fernando Pessoa, CIAGEB-UFP, 
      REQUIMTE-Universidade do Porto, Oporto, Portugal.
FAU - Carqueja, T
AU  - Carqueja T
AD  - Medical Department, Novartis Farma, Porto Salvo, Portugal.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20160107
PL  - England
TA  - J Hum Hypertens
JT  - Journal of human hypertension
JID - 8811625
SB  - IM
MH  - Aged
MH  - Albuminuria/*diagnosis/*epidemiology
MH  - Area Under Curve
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/diagnosis/*epidemiology
MH  - Diabetic Nephropathies/*diagnosis/*epidemiology
MH  - Female
MH  - Humans
MH  - Hypertension/diagnosis/*epidemiology
MH  - Male
MH  - Mass Screening/*methods
MH  - Middle Aged
MH  - Nephelometry and Turbidimetry
MH  - Portugal/epidemiology
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Primary Health Care
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Urinalysis
EDAT- 2016/01/08 06:00
MHDA- 2018/01/24 06:00
CRDT- 2016/01/08 06:00
PHST- 2015/02/24 00:00 [received]
PHST- 2015/10/22 00:00 [revised]
PHST- 2015/11/03 00:00 [accepted]
PHST- 2016/01/08 06:00 [pubmed]
PHST- 2018/01/24 06:00 [medline]
PHST- 2016/01/08 06:00 [entrez]
AID - jhh2015120 [pii]
AID - 10.1038/jhh.2015.120 [doi]
PST - ppublish
SO  - J Hum Hypertens. 2016 Nov;30(11):726-730. doi: 10.1038/jhh.2015.120. Epub 2016 
      Jan 7.