PMID- 26742646
OWN - NLM
STAT- MEDLINE
DCOM- 20170227
LR  - 20181113
IS  - 1305-3612 (Electronic)
IS  - 1305-3825 (Print)
IS  - 1305-3825 (Linking)
VI  - 22
IP  - 2
DP  - 2016 Mar-Apr
TI  - Abnormal spontaneous brain activity in minimal hepatic encephalopathy: 
      resting-state fMRI study.
PG  - 196-200
LID - 10.5152/dir.2015.15208 [doi]
AB  - PURPOSE: We aimed to assess the abnormality of baseline spontaneous brain 
      activity in minimal hepatic encephalopathy (MHE) by amplitude of low frequency 
      fluctuation (ALFF) and fraction ALFF (fALFF). METHODS: A total of 14 MHE patients 
      and 14 healthy controls were included in our study. Both ALFF and fALFF of 
      functional magnetic resonance imaging were calculated for statistical analysis. 
      RESULTS: Compared with healthy controls, patients with MHE had significantly 
      decreased ALFF in the bilateral medial prefrontal cortex (MPFC), left superior 
      frontal gyrus, right precentral gyrus, left opercular part of inferior frontal 
      gyrus, left gyrus rectus, bilateral precuneus, and the posterior lobe of right 
      cerebellum; and they had significantly decreased fALFF in the bilateral MPFC, 
      right middle frontal gyrus, right superior temporal gyrus, and the posterior lobe 
      of left cerebellum. CONCLUSION: ALFF and fALFF changes in many brain regions 
      demonstrate abnormality of the spontaneous neuronal activity in MHE. Especially 
      the impairment of right precuneus and left MPFC may play a critical role in 
      manifestation of MHE. Changes of ALFF and fALFF in the precuneus and the MPFC can 
      be used as a potential marker for MHE.
FAU - Zhong, Wei-Jia
AU  - Zhong WJ
AD  - Department of Radiology, the Second Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China. zhaojiannong3060@163.com.
FAU - Zhou, Zhi-Ming
AU  - Zhou ZM
FAU - Zhao, Jian-Nong
AU  - Zhao JN
FAU - Wu, Wei
AU  - Wu W
FAU - Guo, Da-Jing
AU  - Guo DJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Turkey
TA  - Diagn Interv Radiol
JT  - Diagnostic and interventional radiology (Ankara, Turkey)
JID - 101241152
SB  - IM
MH  - Brain/diagnostic imaging/*physiopathology
MH  - Brain Mapping
MH  - Brain Waves/physiology
MH  - Female
MH  - Hepatic Encephalopathy/*diagnostic imaging/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Rest/physiology
PMC - PMC4790075
EDAT- 2016/01/09 06:00
MHDA- 2017/02/28 06:00
PMCR- 2016/03/01
CRDT- 2016/01/09 06:00
PHST- 2016/01/09 06:00 [entrez]
PHST- 2016/01/09 06:00 [pubmed]
PHST- 2017/02/28 06:00 [medline]
PHST- 2016/03/01 00:00 [pmc-release]
AID - dir-22-2-196 [pii]
AID - 10.5152/dir.2015.15208 [doi]
PST - ppublish
SO  - Diagn Interv Radiol. 2016 Mar-Apr;22(2):196-200. doi: 10.5152/dir.2015.15208.