PMID- 26742763
OWN - NLM
STAT- MEDLINE
DCOM- 20161222
LR  - 20181113
IS  - 1936-0541 (Electronic)
IS  - 1936-0533 (Linking)
VI  - 10
IP  - 3
DP  - 2016 May
TI  - Liver progenitor cells-mediated liver regeneration in liver cirrhosis.
PG  - 440-7
LID - 10.1007/s12072-015-9693-2 [doi]
AB  - Cirrhosis is defined as the histological development of regenerative nodules 
      surrounded by fibrous bands in response to chronic liver injury. In cirrhotic 
      liver where hepatocytes proliferation is compromised, liver progenitor cells 
      (LPCs) are activated and then differentiated into hepatocytes and cholangiocytes, 
      leading to the generation of regenerative nodules and functional restoration. 
      Here, we summarize and discuss recent findings on the mechanisms underlying 
      LPCs-mediated regeneration in liver cirrhosis. Firstly, we provide recent 
      research on the mechanism underlying LPCs activation in severe or chronic liver 
      injury. Secondly, we present new and exciting data on exploring the origin of 
      LPCs, which reveal that the hepatocytes give rise to duct-like progenitors that 
      then differentiate back into hepatocytes in chronic liver injury or liver 
      cirrhosis. Finally, we highlight recent findings from the literature exploring 
      the role of LPCs niche in directing the behavior and fate of LPCs. This 
      remarkable insight into the cellular and molecular mechanisms of LPCs-mediated 
      regeneration in liver cirrhosis will provide a basis for translating this 
      knowledge into clinical application.
FAU - Shang, Haitao
AU  - Shang H
AD  - Department of Gastroenterology, Binzhou Medical University Hospital, Binzhou, 
      256603, People's Republic of China.
FAU - Wang, Zhijun
AU  - Wang Z
AD  - Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, People's Republic of China.
FAU - Song, Yuhu
AU  - Song Y
AD  - Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, People's Republic of China. 
      yuhusong@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160107
PL  - United States
TA  - Hepatol Int
JT  - Hepatology international
JID - 101304009
SB  - IM
MH  - Humans
MH  - Liver/*cytology/physiopathology
MH  - Liver Cirrhosis/*physiopathology
MH  - Liver Regeneration/*physiology
MH  - Stem Cells/*physiology
OTO - NOTNLM
OT  - Liver cirrhosis
OT  - Liver progenitor cells
OT  - Niche
OT  - Origin
EDAT- 2016/01/09 06:00
MHDA- 2016/12/23 06:00
CRDT- 2016/01/09 06:00
PHST- 2015/07/20 00:00 [received]
PHST- 2015/12/07 00:00 [accepted]
PHST- 2016/01/09 06:00 [entrez]
PHST- 2016/01/09 06:00 [pubmed]
PHST- 2016/12/23 06:00 [medline]
AID - 10.1007/s12072-015-9693-2 [pii]
AID - 10.1007/s12072-015-9693-2 [doi]
PST - ppublish
SO  - Hepatol Int. 2016 May;10(3):440-7. doi: 10.1007/s12072-015-9693-2. Epub 2016 Jan 
      7.