PMID- 26745129
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20190606
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 16
IP  - 18
DP  - 2015
TI  - Expression and Clinical Significance of Sushi Domain- Containing Protein 3 
      (SUSD3) and Insulin-like Growth Factor-I Receptor (IGF-IR) in Breast Cancer.
PG  - 8633-6
AB  - BACKGROUND: To investigate the expression of insulin-like growth factor-I 
      receptor (IGF-IR) and sushi domaincontaining protein 3 (SUSD3) in breast cancer 
      tissue, and analyze their relationship with clinical parameters and the 
      correlation betweenthe two proteins. MATERIALS AND METHODS: The expression of 
      IGF-IR and SUSD3 in 100 cases of breast cancer tissues and adjacent normal breast 
      tissues after surgery was detected by immunohistochemical technique MaxVisionTM, 
      and the relationship with clinical pathological features was further analyzed. 
      RESULTS: The positive rate of IGF-IR protein was 86.0% in breast cancer, higher 
      than 3.0% in adjacent normalbreast tissue (P<0.05) .The positive expression rate 
      of SUSD3 protein was 78.0% in breast cancer, higher than 2.0% in adjacent normal 
      breast tissue (P<0.05). The expression of IGF-IR and SUSD3 was related to 
      estrogen receptor and pathological types (P<0.05),but not with age, stage, the 
      expression of HER-2 and Ki-67 (P>0. 05). The expression of IGF-IR and SUSD3 in 
      breast cancer tissue was positively related (r= 0.553, P<0.01). CONCLUSIONS: The 
      expression of IGF-IR and SUSD3 may be correlated to the occurrence and 
      development of breast cancer. The combined detection of IGF-IR, SUSD3 and ER may 
      play an important role in judging prognosis and guiding adjuvant therapy after 
      surgery of breast cancer.
FAU - Zhao, Shuang
AU  - Zhao S
AD  - Jinling Hospital, Nanjing, Jiangsu, China E-mail : 13327800182@189.cn.
FAU - Chen, Shuang-Shuang
AU  - Chen SS
FAU - Gu, Yuan
AU  - Gu Y
FAU - Jiang, En-Ze
AU  - Jiang EZ
FAU - Yu, Zheng-Hong
AU  - Yu ZH
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Membrane Proteins)
RN  - 0 (SUSD3 protein, human)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*metabolism
MH  - Breast Neoplasms/metabolism/*pathology
MH  - Carcinoma, Ductal, Breast/metabolism/*pathology
MH  - Carcinoma, Lobular/metabolism/*pathology
MH  - Estrogen Receptor alpha/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Membrane Proteins/*metabolism
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Receptor, ErbB-2/metabolism
MH  - Receptor, IGF Type 1/*metabolism
EDAT- 2016/01/09 06:00
MHDA- 2016/10/07 06:00
CRDT- 2016/01/09 06:00
PHST- 2016/01/09 06:00 [entrez]
PHST- 2016/01/09 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
AID - 10.7314/apjcp.2015.16.18.8633 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2015;16(18):8633-6. doi: 10.7314/apjcp.2015.16.18.8633.