PMID- 26747260
OWN - NLM
STAT- MEDLINE
DCOM- 20170309
LR  - 20200330
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Print)
IS  - 0938-7994 (Linking)
VI  - 26
IP  - 10
DP  - 2016 Oct
TI  - Assessment of intracardiac flow and vorticity in the right heart of patients 
      after repair of tetralogy of Fallot by flow-sensitive 4D MRI.
PG  - 3598-607
LID - 10.1007/s00330-015-4186-1 [doi]
AB  - OBJECTIVES: To comprehensively and quantitatively analyse flow and vorticity in 
      the right heart of patients after repair of tetralogy of Fallot (rTOF) compared 
      with healthy volunteers. METHODS: Time-resolved flow-sensitive 4D MRI was 
      acquired in 24 rTOF patients and 12 volunteers. Qualitative flow evaluation was 
      based on consensus reading of two observers. Quantitative analysis included 
      segmentation of the right atrium (RA) and ventricle (RV) in a four-chamber view 
      to extract volumes and regional haemodynamic information for computation of 
      regional mean and peak vorticity. RESULTS: Right heart intra-atrial, 
      intraventricular and outflow tract flow patterns differed considerably between 
      rTOF patients and volunteers. Peak RA and mean RV vorticity was significantly 
      higher in patients (p = 0.02/0.05). Significant negative correlations were found 
      between patients' maximum and mean RV and RA vorticity and ventricular volumes 
      (p < 0.05). The main pulmonary artery (MPA) regurgitant flow was associated with 
      higher RA and RV vorticity, which was significant for RA maximum and RV mean 
      vorticity (p = 0.01/0.03). CONCLUSION: The calculation of vorticity based on 4D 
      flow data is an alternative approach to assess intracardiac flow changes in rTOF 
      patients compared with qualitative flow visualization. Alterations in 
      intracardiac vorticity could be relevant with regard to the development of RV 
      dilation and impaired function. KEY POINTS: * 4D flow MRI with vorticity 
      calculation enables a novel approach to assess intracardiac flow. * Significantly 
      higher intracardiac vorticity occurred in patients after repair of tetralogy of 
      Fallot. * Regurgitant flow in the main pulmonary artery is associated with higher 
      right heart vorticity.
FAU - Hirtler, Daniel
AU  - Hirtler D
AD  - Department of Congenital Heart Defects and Pediatric Cardiology (Heart Center, 
      University of Freiburg), University Hospital Freiburg, Mathildenstr. 1, 79106, 
      Freiburg, Germany. Daniel.Hirtler@uniklinik-freiburg.de.
FAU - Garcia, Julio
AU  - Garcia J
AD  - Department of Radiology, Northwestern University Feinberg School of Medicine, 
      Chicago, IL, USA.
FAU - Barker, Alex J
AU  - Barker AJ
AD  - Department of Radiology, Northwestern University Feinberg School of Medicine, 
      Chicago, IL, USA.
FAU - Geiger, Julia
AU  - Geiger J
AD  - Department of Radiology, University Childrens' Hospital Zurich, Zurich, 
      Switzerland.
LA  - eng
GR  - K25 HL119608/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20160108
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Coronary Circulation/physiology
MH  - Female
MH  - Heart Atria/diagnostic imaging/physiopathology
MH  - Heart Ventricles/diagnostic imaging/physiopathology
MH  - Hemodynamics
MH  - Humans
MH  - Imaging, Three-Dimensional/methods
MH  - Infant
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Tetralogy of Fallot/*diagnostic imaging/physiopathology/*surgery
MH  - Young Adult
PMC - PMC4938791
MID - NIHMS780339
OTO - NOTNLM
OT  - 4D flow MRI
OT  - Intracardiac flow
OT  - Right heart
OT  - Tetralogy of Fallot
OT  - Vorticity
EDAT- 2016/01/10 06:00
MHDA- 2017/03/10 06:00
PMCR- 2017/10/01
CRDT- 2016/01/10 06:00
PHST- 2015/03/13 00:00 [received]
PHST- 2015/12/21 00:00 [accepted]
PHST- 2015/10/22 00:00 [revised]
PHST- 2016/01/10 06:00 [entrez]
PHST- 2016/01/10 06:00 [pubmed]
PHST- 2017/03/10 06:00 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
AID - 10.1007/s00330-015-4186-1 [pii]
AID - 10.1007/s00330-015-4186-1 [doi]
PST - ppublish
SO  - Eur Radiol. 2016 Oct;26(10):3598-607. doi: 10.1007/s00330-015-4186-1. Epub 2016 
      Jan 8.