PMID- 26748225
OWN - NLM
STAT- MEDLINE
DCOM- 20160627
LR  - 20160220
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 146
DP  - 2016 Apr
TI  - Internal exposure levels of typical POPs and their associations with childhood 
      asthma in Shanghai, China.
PG  - 125-35
LID - S0013-9351(15)30188-2 [pii]
LID - 10.1016/j.envres.2015.12.026 [doi]
AB  - Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and 
      organochlorine pesticides (OCPs) are common persistent organic pollutants (POPs) 
      that may be associated with childhood asthma. The concentrations of PBDEs, PCBs 
      and OCPs were analyzed in pooled serum samples from both asthmatic and 
      non-asthmatic children. The differences in the internal exposure levels between 
      the case and control groups were tested (p value <0.0012). The associations 
      between the internal exposure concentrations of the POPs and childhood asthma 
      were estimated based on the odds ratios (ORs) calculated using logistic 
      regression models. There were significant differences in three PBDEs, 26 PCBs and 
      seven OCPs between the two groups, with significantly higher levels in the cases. 
      The multiple logistic regression models demonstrated that the internal exposure 
      concentrations of a number of the POPs (23 PCBs, p,p'-DDE and alpha-HCH) were 
      positively associated with childhood asthma. Some synergistic effects were 
      observed when the children were co-exposed to the chemicals. BDE-209 was 
      positively associated with asthma aggravation. This study indicates the potential 
      relationships between the internal exposure concentrations of particular POPs and 
      the development of childhood asthma.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Meng, Ge
AU  - Meng G
AD  - School of Public Health, Shanghai Jiaotong University, Shanghai 200025, PR China.
FAU - Feng, Yan
AU  - Feng Y
AD  - School of Public Health, Shanghai Jiaotong University, Shanghai 200025, PR China.
FAU - Nie, Zhiqing
AU  - Nie Z
AD  - School of Environmental Science & Engineering, Shanghai Jiaotong University, 
      Shanghai 200240, PR China.
FAU - Wu, Xiaomeng
AU  - Wu X
AD  - School of Public Health, Shanghai Jiaotong University, Shanghai 200025, PR China.
FAU - Wei, Hongying
AU  - Wei H
AD  - School of Public Health, Shanghai Jiaotong University, Shanghai 200025, PR China.
FAU - Wu, Shaowei
AU  - Wu S
AD  - Department of Occupational and Environmental Health Sciences, Peking University 
      School of Public Health, Beijing 100191, China; Department of Environmental 
      Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
FAU - Yin, Yong
AU  - Yin Y
AD  - Shanghai Children's Medical Center, Shanghai 200127, PR China. Electronic 
      address: yinyong9999@163.com.
FAU - Wang, Yan
AU  - Wang Y
AD  - School of Public Health, Shanghai Jiaotong University, Shanghai 200025, PR China; 
      Hongqiao International Institute of Medicine, Shanghai Tongren Hospital / Faculty 
      of Basic Medicine (or Faculty of Public Health), Shanghai Jiao Tong University 
      School of Medicine; MOE and Shanghai Key Laboratory of Children's Environmental 
      Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China. Electronic address: wangyanshjy@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151231
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Asthma/chemically induced/*epidemiology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - *Environmental Exposure
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Halogenated Diphenyl Ethers/*blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Incidence
MH  - Male
MH  - Polychlorinated Biphenyls/*blood
MH  - Urban Health
OTO - NOTNLM
OT  - Childhood asthma
OT  - Internal exposure
OT  - Logistic regression model
OT  - Persistent organic pollutants
OT  - Positive association.
EDAT- 2016/01/10 06:00
MHDA- 2016/06/28 06:00
CRDT- 2016/01/10 06:00
PHST- 2015/10/06 00:00 [received]
PHST- 2015/12/16 00:00 [revised]
PHST- 2015/12/21 00:00 [accepted]
PHST- 2016/01/10 06:00 [entrez]
PHST- 2016/01/10 06:00 [pubmed]
PHST- 2016/06/28 06:00 [medline]
AID - S0013-9351(15)30188-2 [pii]
AID - 10.1016/j.envres.2015.12.026 [doi]
PST - ppublish
SO  - Environ Res. 2016 Apr;146:125-35. doi: 10.1016/j.envres.2015.12.026. Epub 2015 
      Dec 31.