PMID- 26749303
OWN - NLM
STAT- MEDLINE
DCOM- 20170707
LR  - 20210109
IS  - 2326-5205 (Electronic)
IS  - 2326-5191 (Print)
IS  - 2326-5191 (Linking)
VI  - 68
IP  - 6
DP  - 2016 Jun
TI  - Brief Report: Proatherogenic Cytokine Microenvironment in the Aortic Adventitia 
      of Patients With Rheumatoid Arthritis.
PG  - 1361-6
LID - 10.1002/art.39574 [doi]
AB  - OBJECTIVE: Patients with rheumatoid arthritis (RA) are at increased risk of 
      developing cardiovascular disease (CVD) via mechanisms that have not yet been 
      defined. Inflammatory pathways, in particular within the vascular adventitia, are 
      implicated in the pathogenesis of primary CVD but could be amplified in RA at the 
      local tissue level. The aim of this study was to examine the aortic adventitia of 
      coronary artery disease (CAD) patients with or without RA to determine the 
      cytokine profile contained therein. METHODS: Aortic adventitia and internal 
      thoracic artery biopsy specimens obtained from 19 RA patients and 20 non-RA 
      patients undergoing coronary artery bypass graft surgery were examined by 
      immunohistochemistry. RESULTS: Interleukin-18 (IL-18), IL-33, and tumor necrosis 
      factor (TNF) were expressed in aortic adventitia biopsy specimens from both 
      groups, and expression of these cytokines was significantly higher in RA 
      patients. In RA patients, IL-33 expression in endothelial cells correlated 
      positively with the number of swollen joints, suggesting a link between the 
      systemic disease state and the local vascular tissue microlesion. CONCLUSION: The 
      presence of the proinflammatory cytokines IL-18, IL-33, and TNF may play a role 
      in the inflammatory process within the adventitia that contributes to plaque 
      formation and destabilization. In theory, the amplified expression of these 
      cytokines may contribute to the known increased occurrence and severity of CAD in 
      patients with RA.
CI  - (c) 2016 The Authors. Arthritis & Rheumatology published by Wiley Periodicals, Inc. 
      on behalf of the American College of Rheumatology.
FAU - Ahmed, Ammad
AU  - Ahmed A
AD  - University of Glasgow, Glasgow, UK.
FAU - Hollan, Ivana
AU  - Hollan I
AD  - Hospital for Rheumatic Diseases, Lillehammer, Norway.
FAU - Curran, Samuel A
AU  - Curran SA
AD  - University of Glasgow, Glasgow, UK.
FAU - Kitson, Susan M
AU  - Kitson SM
AD  - University of Glasgow, Glasgow, UK.
FAU - Riggio, Marcello P
AU  - Riggio MP
AD  - University of Glasgow, Glasgow, UK.
FAU - Mikkelsen, Knut
AU  - Mikkelsen K
AD  - Hospital for Rheumatic Diseases, Lillehammer, Norway.
FAU - Almdahl, Sven M
AU  - Almdahl SM
AD  - University Hospital of North Norway, Tromso, Norway.
FAU - Aukrust, Pal
AU  - Aukrust P
AD  - Oslo University Hospital Rikshospitalet and University of Oslo, Oslo, Norway.
FAU - McInnes, Iain B
AU  - McInnes IB
AD  - University of Glasgow, Glasgow, UK.
FAU - Goodyear, Carl S
AU  - Goodyear CS
AD  - University of Glasgow, Glasgow, UK.
LA  - eng
GR  - 19701/ARC_/Arthritis Research UK/United Kingdom
GR  - 19701/VAC_/Versus Arthritis/United Kingdom
PT  - Journal Article
PL  - United States
TA  - Arthritis Rheumatol
JT  - Arthritis & rheumatology (Hoboken, N.J.)
JID - 101623795
RN  - 0 (IL33 protein, human)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-33)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adventitia/*chemistry
MH  - Aged
MH  - Aorta/*chemistry
MH  - Arthritis, Rheumatoid/*immunology
MH  - Atherosclerosis/immunology
MH  - Cellular Microenvironment
MH  - Female
MH  - Humans
MH  - Interleukin-18/*analysis
MH  - Interleukin-33/*analysis
MH  - Male
MH  - Tumor Necrosis Factor-alpha/*analysis
PMC - PMC4920270
EDAT- 2016/01/11 06:00
MHDA- 2017/07/08 06:00
PMCR- 2016/06/24
CRDT- 2016/01/11 06:00
PHST- 2015/05/21 00:00 [received]
PHST- 2015/12/29 00:00 [accepted]
PHST- 2016/01/11 06:00 [entrez]
PHST- 2016/01/11 06:00 [pubmed]
PHST- 2017/07/08 06:00 [medline]
PHST- 2016/06/24 00:00 [pmc-release]
AID - ART39574 [pii]
AID - 10.1002/art.39574 [doi]
PST - ppublish
SO  - Arthritis Rheumatol. 2016 Jun;68(6):1361-6. doi: 10.1002/art.39574.