PMID- 26751715
OWN - NLM
STAT- MEDLINE
DCOM- 20170512
LR  - 20170512
IS  - 1876-7478 (Electronic)
IS  - 1874-7787 (Linking)
VI  - 27
DP  - 2016 Jun
TI  - Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as 
      candidate regulatory factors of mantle function.
PG  - 25-35
LID - S1874-7787(15)30059-3 [pii]
LID - 10.1016/j.margen.2015.12.003 [doi]
AB  - Allatostatin-type A (AST-A), kisspeptin (KISS) and galanin (GAL) G-protein 
      coupled receptor (GPCR) systems share a common ancestral origin in arthropods and 
      the vertebrates where they regulate metabolism and reproduction. The molluscs are 
      the second most diverse phylum in the animal kingdom, they occupy an important 
      phylogenetic position, and their genome is more similar to deuterostomes than the 
      arthropods and nematodes and thus they are good models for studies of gene family 
      evolution and function. This mini-review intends to extend the current knowledge 
      about AST-A, KISS and GAL GPCR system evolution and their putative function in 
      the mollusc mantle. Comparative evolutionary analysis of the target GPCR systems 
      was established by identifying homologues in genomes and tissue transcriptome 
      datasets available for molluscs and comparing them to those of other metazoan 
      systems. Studies in arthropods have revealed the existence of the AST-A system 
      but the loss of homologues of the KISS and GAL systems. Homologues of the insect 
      AST-AR and vertebrate KISSR genes were found in molluscs but putative GALR genes 
      were absent. Receptor gene number suggested that members of this family have 
      suffered lineage specific evolution during the molluscan radiation. In molluscs, 
      orthologues of the insect AST-A peptides were not identified but buccalin 
      peptides that are structurally related were identified and are putative receptor 
      agonists. The identification of AST-AR and KISSR genes in molluscs strengthens 
      the hypotheses that in metazoans members of the AST-AR subfamily share 
      evolutionary proximity with KISSRs. The variable number of receptors and large 
      repertoire of buccalin peptides may be indicative of the functional diversity of 
      the AST-AR/KISSR systems in molluscs. The identification of AST-A and KISS 
      receptors and ligands in the mantle transcriptome indicates that in molluscs they 
      may have acquired a novel function and may play a role in shell development or 
      sensory detection in the mantle.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Cardoso, Joao C R
AU  - Cardoso JC
AD  - Comparative Endocrinology and Integrative Biology, Centre of Marine Sciences, 
      Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal. Electronic 
      address: jccardo@ualg.pt.
FAU - Felix, Rute C
AU  - Felix RC
AD  - Comparative Endocrinology and Integrative Biology, Centre of Marine Sciences, 
      Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal.
FAU - Bjarnmark, Nadege
AU  - Bjarnmark N
AD  - Comparative Endocrinology and Integrative Biology, Centre of Marine Sciences, 
      Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal.
FAU - Power, Deborah M
AU  - Power DM
AD  - Comparative Endocrinology and Integrative Biology, Centre of Marine Sciences, 
      Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151230
PL  - Netherlands
TA  - Mar Genomics
JT  - Marine genomics
JID - 101475200
RN  - 0 (Kisspeptins)
RN  - 0 (Ligands)
RN  - 0 (Neuropeptides)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 110119-33-0 (allatostatin)
RN  - 88813-36-9 (Galanin)
SB  - IM
MH  - Animal Shells/growth & development
MH  - Animals
MH  - Bivalvia/*genetics/growth & development/metabolism
MH  - Calcification, Physiologic
MH  - *Evolution, Molecular
MH  - Galanin/genetics/metabolism
MH  - Kisspeptins/*genetics/metabolism
MH  - Ligands
MH  - Neuropeptides/*genetics/metabolism
MH  - Receptors, G-Protein-Coupled/*genetics/metabolism
OTO - NOTNLM
OT  - AST-A and KISS GPCRs
OT  - Evolution
OT  - Genes and transcripts
OT  - Molluscs
OT  - Peptides
EDAT- 2016/01/12 06:00
MHDA- 2017/05/13 06:00
CRDT- 2016/01/12 06:00
PHST- 2015/09/02 00:00 [received]
PHST- 2015/12/02 00:00 [revised]
PHST- 2015/12/12 00:00 [accepted]
PHST- 2016/01/12 06:00 [entrez]
PHST- 2016/01/12 06:00 [pubmed]
PHST- 2017/05/13 06:00 [medline]
AID - S1874-7787(15)30059-3 [pii]
AID - 10.1016/j.margen.2015.12.003 [doi]
PST - ppublish
SO  - Mar Genomics. 2016 Jun;27:25-35. doi: 10.1016/j.margen.2015.12.003. Epub 2015 Dec 
      30.