PMID- 26753957
OWN - NLM
STAT- MEDLINE
DCOM- 20170206
LR  - 20191210
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 37
IP  - 7
DP  - 2016 Jul
TI  - High expression of constitutive photomorphogenic 1 (COP1) is associated with poor 
      prognosis in bladder cancer.
PG  - 8917-22
LID - 10.1007/s13277-015-4765-4 [doi]
AB  - The present study was to investigate the expression and prognostic value of 
      constitutive photomorphogenic 1 (COP1) in bladder cancer. In our study, real-time 
      quantitative PCR (RT-PCR) was performed to detect 10 pairs of fresh bladder 
      cancer (BCa) and adjacent noncancerous tissues. In addition, immunohistochemistry 
      was utilized to detect the expression of COP1 in 174 clinical bladder cancer 
      samples. What is more, the correlation of COP1 expression and clinicopathological 
      features and clinical outcomes were analyzed. The expression levels of COP1 in 
      clinical bladder cancer were much higher than that in paired adjacent 
      noncancerous tissues (p < 0.0001). High expression of COP1 was closely related 
      with differentiation (p = 0.040) and recurrence (p = 0.001) of patients with 
      bladder cancer. Kaplan-Meier analysis revealed that the expression of COP1 was 
      closely correlated with overall survival (p = 0.048) of bladder cancer, while, 
      recurrence-free survival (p = 0.201). Moreover, Cox multivariate regression 
      analyses showed that COP1 expression was an independent predictor of overall 
      survival (OS; p = 0.027, hazard ratio = 2.127, confidence interval 0.814 to 
      9.736). Based on our data, the present study suggests that high expression of 
      COP1 may be a novel biological indicator for evaluation of poor prognosis in 
      bladder cancer.
FAU - Li, Jianlong
AU  - Li J
AD  - Department of Urology, the Second Affiliated Hospital of Nanchang University, 
      330006, Nanchang, Jiangxi Province, People's Republic of China.
FAU - Wang, Longwang
AU  - Wang L
AD  - Department of Urology, the Second Affiliated Hospital of Nanchang University, 
      330006, Nanchang, Jiangxi Province, People's Republic of China.
FAU - Xiao, Ruihai
AU  - Xiao R
AD  - Department of Urology, the Second Affiliated Hospital of Nanchang University, 
      330006, Nanchang, Jiangxi Province, People's Republic of China.
FAU - Pan, Qiufeng
AU  - Pan Q
AD  - Department of Urology, the Second Affiliated Hospital of Nanchang University, 
      330006, Nanchang, Jiangxi Province, People's Republic of China.
FAU - Huang, Hongwei
AU  - Huang H
AD  - Department of Urology, the Second Affiliated Hospital of Nanchang University, 
      330006, Nanchang, Jiangxi Province, People's Republic of China.
FAU - Kuang, Renrui
AU  - Kuang R
AD  - Department of Urology, the Second Affiliated Hospital of Nanchang University, 
      330006, Nanchang, Jiangxi Province, People's Republic of China. 
      kuangrenruiapple@126.com.
LA  - eng
PT  - Journal Article
DEP - 20160111
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - EC 2.3.2.27 (COP1 protein, human)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease-Free Survival
MH  - Female
MH  - Gene Expression Regulation, Neoplastic/genetics
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/genetics/pathology
MH  - Prognosis
MH  - Regression Analysis
MH  - Ubiquitin-Protein Ligases/*genetics
MH  - Urinary Bladder Neoplasms/*genetics/*pathology
OTO - NOTNLM
OT  - Bladder cancer
OT  - COP1 expression
OT  - Prognosis
EDAT- 2016/01/13 06:00
MHDA- 2017/02/07 06:00
CRDT- 2016/01/13 06:00
PHST- 2015/11/02 00:00 [received]
PHST- 2015/12/29 00:00 [accepted]
PHST- 2016/01/13 06:00 [entrez]
PHST- 2016/01/13 06:00 [pubmed]
PHST- 2017/02/07 06:00 [medline]
AID - 10.1007/s13277-015-4765-4 [pii]
AID - 10.1007/s13277-015-4765-4 [doi]
PST - ppublish
SO  - Tumour Biol. 2016 Jul;37(7):8917-22. doi: 10.1007/s13277-015-4765-4. Epub 2016 
      Jan 11.